The relationshp of clinical‐pathologic status and adiuvant treatment with natural hller cell activity in stage I and II endometrial carcinoma

Abstract

I(.I(I Oh.v/er Gjwecol Scmd 1994: 73: 652-657. (ij Acta Obstet Gynecol Scand 1994Ohjwriw. The aim of our study was to evaluate the basal immune reactivity in patients with locally advanced endometrial carcinoma, and the immune modulating effect of adjuvant treatment in cancer population randomized to endocrine or radiation therapy. M t r /~r . ; d otitl t w k o d s . Forty-three patients with F I G 0 stage I and II endometrial carcinoma, treated with primary radical surgery, were randomly selected to receive endocrine (medroxyprogesterone acetate 30 mg weekly and Tamoxifen 300 mg weekly, given consecutively) or radiation adjuvant treatment (external beam photon treatment of the whole pelvis, with an average total dose of 3680 cGy rad). The immune assay included the evaluation of natural killer cell activity by target cell retention of the fluorescent dye carboxyfluoresceyn diacetate. using sensitive cell line K 562. The immunological monitoring was performed before surgery, and !hen before, during, and after adjuvant treatment. Nine patients, who refused any adjuvant treatment, were recruited as controls. Kc.trl1r.s. Patients, matched for age and demographic characteristics. with locally advanced endometrial carcinoma had significantly lower mean values of natural killer activity than in henlthy controls: the decrease of natural cytotoxicity was significantly related to the depth of inyometrial invasion. The adjuvant treatment was associated with a significant immune modulation: patients in endocrine therapeutic regimen showed an increase of natural killer activity. while patients in radiation therapy had a reduction; in the control group there was no significant modification of natural cytotoxicity during negative follow up. ~'~i / i r , /~~. s i f~t i . s .

Physical exercise and immune system function in cancer survivors

“…In particular, radiotherapy has been shown to cause significant reductions in both NK cell cytolytic activity in breast carcinoma survivors24 and the number of NK cells (CD3–CD16+CD56+) in colorectal carcinoma survivors 25. Similarly, Garzetti et al reported that Stages I and II endometrial carcinoma survivors who received radiotherapy demonstrated a significant reduction in NK cell cytolytic activity 26. Squamous cell lung carcinoma survivors who received radiotherapy have been shown to have significant reductions in the total number of lymphocyte, T cells (CD4+, CD8+), and T cell proliferation in response to mitogenic stimulation 27.…”

Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins

“…An increased number of CD8 + CTLs at the border of endometrial carcinomas have been associated with improved survival [6]. In contrast, only a small number of NK cells are present in endometrial carcinomas, and decreased cytotoxic activity of NK cells isolated from the peripheral blood of patients with endometrial carcinoma has been reported [7,8].…”

Immune disorder in endometrial cancer: Immunosuppressive microenvironment, mechanisms of immune evasion and immunotherapy (Review)

“…NK cell activation is impaired in the tumor microenvironment, including the EC microenvironment. Garzetti et al (35) suggested that locally advanced stage I and II ECs had significantly lower mean values of NK cell activity compared with healthy controls. Furthermore, a decrease in NK cell activity increased the depth of myometrial tumor invasion (35).…”

“…Garzetti et al (35) suggested that locally advanced stage I and II ECs had significantly lower mean values of NK cell activity compared with healthy controls. Furthermore, a decrease in NK cell activity increased the depth of myometrial tumor invasion (35). NK cell activity also diminished with increased nuclear grade in stage I EC.…”