2010
DOI: 10.1016/j.humpath.2009.06.012
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Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins

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Cited by 30 publications
(19 citation statements)
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“…In fact, they are the targets of many immunotherapy protocols [10]. Also, its presence in the tumor stroma has been associated with prognosis in several carcinomas including ovarian, colon and EEC [11][12][13][14].…”
Section: Discussionmentioning
confidence: 99%
“…In fact, they are the targets of many immunotherapy protocols [10]. Also, its presence in the tumor stroma has been associated with prognosis in several carcinomas including ovarian, colon and EEC [11][12][13][14].…”
Section: Discussionmentioning
confidence: 99%
“…This arrangement of cells in the peritumorous zone contradicts the idea of direct interaction of NK cells with malignancy. 11,13,14 Moreover, experimental data by Spano and Zollo 15 revealed a tumor-associated functional defectiveness of NK cells, probably caused by tumor-associated cytokines.…”
Section: Discussionmentioning
confidence: 99%
“…Treatment time no <6 months to accurately assess response, was also recommended by Gunderson and colleagues in a recent review of women receiving progestin therapy for atypical endometrial hyperplasia. However, when meta‐analyses of studies are evaluated the results are less comparable because of variation in type, dose, regimen and duration of oral treatment …”
Section: Discussionmentioning
confidence: 99%