The Relationships of Leptin, Adiponectin Levels and Paraoxonase Activity with Metabolic and Cardiovascular Risk Factors in Females Treated with Psychiatric Drugs

Abstract

Ozenoglu A, Balci H, Ugurlu S, Caglar E, Uzun H, Sarkis C et al. The relationships of leptin, adiponectin levels and paraoxonase activity with metabolic and cardiovascular risk factors in females treated with psychiatric drugs. Clinics. 2008; 63(5):651-60. OBJECTIVES:The aim of this study was to investigate serum leptin, adiponectin and paraoxonase1 levels in adult females receiving pharmacotherapy for various psychiatric disorders. METHODS:The study group consisted of 32 obese females (mean age 40.53 ± 11.00 years, mean body mass index 35.44 ± 5.33 kg/m 2 ) who were receiving treatment for psychiatric disorders, and the control group included 22 obese females (mean age 35.95 ± 9.16 years, mean body mass index 30.78 ± 3.33 kg/m 2 ) who were free of psychiatric disorders. Analyses were performed using a bioelectrical impedance device. Fasting blood samples were obtained for complete blood count and various biochemical tests, including determination of leptin, adiponectin and paraoxonase1 activity. RESULTS: Body mass index, waist and hip circumference, body fat percentage, fasting blood glucose, insulin, glycosylated hemoglobin, homeostasis model assesment of insulin resistance, alanine transaminase, aspartate tarnsaminase, and leptin levels were significantly higher in the study group than in controls. Although body weight was positively correlated with leptin levels in both groups, body weight was negatively correlated with adiponectin levels in the control group and positively correlated with adiponectin levels in the study group. In the study group, body mass index and hip circumference correlated positively with leptin levels, hip circumference correlated positively with adiponectin levels, and waist to hip ratio correlated positively with paraoxonase levels. In the control group, body mass index as well as waist and hip circumferences were positively correlated with leptin levels. Weight, body mass index, and hip circumference were also negatively correlated with the adiponectin/leptin ratio in the control group. CONCLUSION: This study indicates a higher risk for obesity-related disorders, particularly metabolic syndrome, diabetes and cardiovascular disease, in patients treated with psychiatric drugs.

There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study

“…Although we didn’t have a control group, the average activity of the enzyme we found in this study was not very different from the activity found by other studies in women without endometriosis (183.7 ± 22.3 U/l in 40 women with no endometriosis in the study of Verit et al, 2008 [10]; 258.29 ± 101.95 U/l in 22 adult females with no endocrine or metabolic disorders or history of drug use in the study of Ozenoglu et al, 2008 [28]; and 240 ± 144 U/l in 200 individual, both men and women, from blood bank serum samples in a study performed by Davis et al, 2009 [29]). Besides, in our study the patients were diagnosed with endometriosis by laparoscopy/laparotomy, and classified according to the American Society for Reproductive Medicine [26] with histological confirmation of the disease, which gives a more accurate diagnosis of the stage of the endometriosis in comparison with visual confirmation alone.…”

Comparative Study of Morphological Characteristics and Body Composition between Different Team Players from Serbian Junior National League: Soccer, Handball, Basketball and Volleyball

“…Adipose tissue is a complex, essential, and highly active metabolic and endocrine organ (Kershaw & Flier, 2004) who communicates with the central nervous system (Costa et al, 2011). In addition to energy storage, also regulate energy metabolism via secreting adipokines into the circulation (Ozenoglu et al, 2008). Adipokines is bioactive peptides, which act at both the local and systemic level.…”

HDL‐paraoxonase and Membrane Lipid Peroxidation: A Comparison Between Healthy and Obese Subjects

“…In addition to its role in energy storage, adipose tissue also secretes various biologically active adipokines such as leptin, and the anti-inflammatory and antiatherosclerotic adiponectin (25). Previous studies have shown correlations between the activity of PON1, and levels of adiponectin and leptin (3,(26)(27)(28). Moreover, the effect of inflammatory cytokines such as tumor necrosis factor-α, whose levels are higher in plasma of obese patients (29), deserves of future studies because they negatively affect PON1 synthesis (30).…”