The Relationships Between Vitamin K and Cognition: A Review of Current Evidence

Alisi, Ludovico; Cao, Roberta; Angelis, Cristina de; Cafolla, Arturo; Caramia, Francesca; Cartocci, Gaia; Librando, Aloisa; Fiorelli, Marco

doi:10.3389/fneur.2019.00239

Cited by 64 publications

(54 citation statements)

References 76 publications

(92 reference statements)

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“…(phylloquinone)-104300 (Alzheimer disease) association has been reported in previous studies (Alisi, et al, 2019). A subnetwork including 46 genes and 44 links were uncovered for this association (Fig 3d).…”

Section: Excellent Performance and General Applicability Of Kddanet Csupporting

confidence: 76%

Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet

Chen

et al. 2019

Preprint

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Inferring novel therapeutic indications of known drugs provides an effective method for fast-speed and low-risk drug development and disease treatment. Various computational tools have been developed to accurately predict potential associations between drugs and diseases. Nevertheless, no method has been designed to unveil pharmacological (toxicological) gene interactions underlying Known Drug-Disease Associations (KDDAs). System-level interpretation and elucidation of molecular mechanism underlying KDDAs remains a main challenge. Here, for the first time, we presented a novel and general computational framework, called KDDANet, for systematic uncovering hidden gene interactions underlying KDDAs from the perspective of complex molecular network. KDDANet effectively implemented minimum cost optimization and graph clustering on a unified flow network model. The excellent performance and general applicability of KDDANet on uncovering hidden genes underlying KDDAs were globally demonstrated by enrichment analysis of known and novel KDDA genes against two well-curated databases across broad types of diseases. Case studies on several types of diseases further highlighted that the potential value of KDDANet on revealing hidden gene interactions underlying 2 KDDAs. Particularly, it's worth noting that KDDANet can reveal the shared gene interactions underlying multiple KDDAs. For facilitating biomedical researchers to explore KDDA molecular mechanisms and guiding drug repurposing, we provided an online web server, http://47.94.193.106/kdda/index, to browse, download and analyze the predicted KDDA gene interactions. Our software and usage instruction were freely available at https://github.com/huayu1111/KDDANet/.

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Section: Excellent Performance and General Applicability Of Kddanet Csupporting

confidence: 76%

Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet

Chen

et al. 2019

Preprint

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“…In the last decade, the bulk of research on vitamin K has shifted beyond coagulation, which further explores its physiological role in skeletal, CVD, and brain health [46,47]. Vitamin K deficiency has been associated with a higher risk of age-related chronic diseases such as osteoporosis, CVD, RA, and OA, which contributes to its onset and progression [5,[48][49][50].…”

Section: Vitamin K Deficiencymentioning

confidence: 99%

Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases

et al. 2020

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Vitamin K health benefits have been recently widely shown to extend beyond blood homeostasis and implicated in chronic low-grade inflammatory diseases such as cardiovascular disease, osteoarthritis, dementia, cognitive impairment, mobility disability, and frailty. Novel and more efficient nutritional and therapeutic options are urgently needed to lower the burden and the associated health care costs of these age-related diseases. Naturally occurring vitamin K comprise the phylloquinone (vitamin K1), and a series of menaquinones broadly designated as vitamin K2 that differ in source, absorption rates, tissue distribution, bioavailability, and target activity. Although vitamin K1 and K2 sources are mainly dietary, consumer preference for diet supplements is growing, especially when derived from marine resources. The aim of this review is to update the reader regarding the specific contribution and effect of each K1 and K2 vitamers in human health, identify potential methods for its sustainable and cost-efficient production, and novel natural sources of vitamin K and formulations to improve absorption and bioavailability. This new information will contribute to foster the use of vitamin K as a health-promoting supplement, which meets the increasing consumer demand. Simultaneously, relevant information on the clinical context and direct health consequences of vitamin K deficiency focusing in aging and age-related diseases will be discussed.

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“…Previous studies mainly focused on animal models or human tissues analysed post mortem [30]. Some investigations had evaluated the relationship between vitamin K and cognitive functions in human subjects [30]. ese studies, however, relied on simple cognitive tests, such as the MMSE.…”

Section: Discussionmentioning

confidence: 99%

“…e reasons behind a positive impact of vitamin K on cognitive status may be explained with the fundamental role of this vitamin on the synthesis of protein S [7,8] and sphingolipids [3,9,10]. ese molecules have been shown to have a key role in ensuring brain signalling and metabolism [7][8][9][10]30].…”

Section: Discussionmentioning

confidence: 99%

Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study

Alisi¹,

Cafolla

Gentili

et al. 2020

Journal of Aging Research

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Objectives. Recent studies have suggested that vitamin K may exert significant effects on the central nervous system. The present study investigates the relationship between vitamin K plasmatic levels and cognitive functions in elderly patients on oral anticoagulant therapy (OAT). Design. At the Thrombosis Centre of Haematology, “Sapienza” University of Rome, 85 patients on OAT, aged between 75 and 92, were randomly enrolled in the study. Patients were on OAT with vitamin K antagonists (VKAs). Vitamin K1 concentrations were determined using standardized High-Performance Liquid Chromatography (HPLC). Cognitive functions were assessed using the Milan Overall Dementia Assessment (MODA). Results. MODA scores are positively correlated to vitamin K1 concentration. Patients with vitamin K1 below 0.100 μg/L and between 0.100 and 0.400 μg/L showed a mean MODA score of 79 ± 5 and 82 ± 3, respectively. Patients with vitamin K1 above 0.400 μg/L had a significantly greater MODA score (89 ± 1). After binning the data into bicentiles, MODA scores are shown to be linearly dependent on vitamin K1 concentrations (p<0.001). Even long-term OAT (>10 years) does not affect MODA scores. Education seems to exert a greater role on the cognitive status in comparison with aging. Conclusions. The study shows a positive association between vitamin K1 concentration and cognitive status in elderly patients (≥75 years) on OAT. The relationship between vitamin K1 concentration and MODA scores is described by a linear model. Cognitive status is not influenced by the duration of OAT but by the years of education.

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The Relationships Between Vitamin K and Cognition: A Review of Current Evidence

Cited by 64 publications

References 76 publications

Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet

Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet

Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases

Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study

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