The Relationship of TPOAb and TGAb with Risk of Thyroid Nodules: A Large Epidemiological Study

Xu, Weimin; Huo, Liangliang; Chen, Zexin; Huang, Yangmei; Jin, Xingyi; Deng, Jing; Zhu, Shankuan; Yu, Yunxian

doi:10.3390/ijerph14070723

Cited by 17 publications

(15 citation statements)

References 30 publications

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“…TPOAb positivity is also associated with other pregnancy complications, such as preterm birth [3]. In the broader context it is worth adding that thyroid antibodies, i.e., TPOAb and TgAb, were positively associated with the risk of thyroid nodules [20].…”

Section: Discussionmentioning

confidence: 99%

Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

Karbownik-Lewińska

Stępniak

Żurawska

et al. 2020

IJERPH

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High-normal TSH can be associated with metabolic abnormalities and infertility. Aims of this study are to analyze retrospectively if routinely measured blood laboratory and anthropometric parameters differ between women of reproductive age with TSH < 2.5 mIU/L and with TSH ≥ 2.5 mIU/L. Retrospective analysis was performed in 466 female inpatients, aged 13–51, hospitalized in an endocrine department. The group of 280 patients with normal thyroid tests (TSH 0.27-4.2 mIU/L; normal FT3 and FT4) was selected and it was divided into two subgroups, i.e., with TSH < 2.5 mIU/L and TSH ≥ 2.5 mIU/L (n = 66; 23.6%). After excluding patients on L-thyroxine treatment (n = 240), those with TSH ≥ 2.5 mIU/L constituted 22.92% (n = 55). In the group of 280 patients with normal thyroid tests, an abnormally high concentration of triglycerides and an abnormally low HDLC/cholesterol ratio occurred more frequently in women with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (17% vs. 7%, p = 0.017; 14% vs. 5%, p = 0.015, respectively). Increased concentration of thyroid antibodies, i.e., TPOAb, occurred more frequently in patients with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (27% vs. 9%, p = 0.001). The same differences were found in the group of 240 patients after excluding those on L-thyroxine treatment. Blood lymphocyte concentration was the only independent linear parameter associated with TSH ≥ 2.5 mIU/L (OR = 1.551, p = 0.024) but only in the group of 280 patients with normal thyroid tests. TSH concentration correlated positively with blood lymphocyte (r = 0.129, p = 0.031) and TPOAb (r = 0.177, p = 0.005) concentrations but only in the group of 280 patients with normal thyroid tests. Less favorable lipid profiles and a higher prevalence of thyroid antibodies in women of reproductive age with high-normal TSH suggests that L-thyroxine treatment should be considered in such patients. The significance of a positive association between high-normal TSH and blood lymphocytes requires further evaluation.

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Section: Discussionmentioning

confidence: 99%

Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

Karbownik-Lewińska

Stępniak

Żurawska

et al. 2020

IJERPH

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“…yroid nodules are one or more lumps made up of abnormal clusters of thyroid cells in the thyroid gland with a variety of etiologies, which can be cystic, solid, or mixed, and are the most common thyroid diseases in clinical settings [1,2]. yroid nodules can be complicated by various thyroid diseases because of its insidious onset, and most of the patients are asymptomatic in the early stage [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…yroid nodules can be complicated by various thyroid diseases because of its insidious onset, and most of the patients are asymptomatic in the early stage [3,4]. e prevalence of thyroid nodules among males and females was 29.49% and 33.15% in Southeast China, respectively [2]. With lifestyle and dietary changes, diabetes, hypertension, metabolic diseases such as hyperlipidemia, fatty liver, hyperuricemia, and obesity are the main chronic diseases affecting the health of residents in China [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Single and Multiple Thyroid Nodules and Its Association with Metabolic Diseases in Chinese: A Cross-Sectional Study

Zou

Sun

Wang

et al. 2020

International Journal of Endocrinology

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Purpose. The present study aims to investigate the prevalence of single and multiple thyroid nodules and its association with metabolic diseases in subjects who participated in the heath examination in China. Methods. This is a cross-sectional study. The participants who attend the physical examination at the Health Management Center of Southwest Hospital, Army Military Medical University, between January 2014 and December 2018, were included. Thyroid nodules were diagnosed by thyroid ultrasound. Multivariable logistic regression was used to investigate the association between metabolic diseases and nodular thyroid disease. Results. A total of 9,146 subjects were included in this study; of them, 2,961 were diagnosed with thyroid nodules, with a prevalence of 32.4%. The prevalence in women was significantly higher than that in men (45.2% vs 26.0%; χ2 = 339.56, P<0.001), and the prevalence was gradually increased with age (Z = 20.05, P<0.001). Multivariable logistic regression analysis indicated that advanced age, female gender, and diabetes mellitus were positively associated with thyroid nodule in the general population. Additionally, the female gender, advanced age, and high LDL-C concentration were positively associated with high risk of multiple thyroid nodules, compared with patients of single thyroid nodule. Males and females showed heterogeneous associations with single and multiple thyroid nodule risk. Conclusions. The prevalence of thyroid nodules was relatively high. Age, female gender, and diabetes are positively associated with nodular thyroid disease. High LDL cholesterolemia is more likely to be associated with multiple thyroid sarcoidosis.

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“…A cross-sectional study of 31 provinces in mainland China showed that the positive rate of anti-TPO antibodies (TPOAb) in Chinese adults was 10.19%, and the positive rate of anti-Tg antibodies (TgAb) was 9.70% [2]. Recent studies have con rmed that TgAb and TPOAb can increase the risk of thyroid cancer and thyroid nodules [3,4]. High levels of thyroid antibodies not only cause hypothyroidism but are also an essential factor in the progression of HT disease.…”

Section: Introductionmentioning

confidence: 99%

Serum Resolvin E1 Levels and Its Relationship with Thyroid Autoimmunity in Hashimoto's Thyroiditis

Song¹,

Sun²,

Zhang³

et al. 2020

Preprint

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Objective: Omega-3 polyunsaturated fatty acids (PUFAs) can produce lipid mediators with both anti-inflammatory and pro-resolution properties, including resolvins. Resolvins have been associated with autoimmune disorders. This study aimed to measure the level of resolvin E1 (RVE1) in the serum of Hashimoto's thyroiditis (HT) patients and healthy controls (HCs) and to further analyze its correlation with thyroid autoantibodies and other clinical indicators.Design, patients and measurements: Fifty-seven participants were recruited—30 untreated HT patients and 27 sex‐ and age‐matched HCs. Levels of serum RVE1 were measured by ELISA according to the manufacturer’s protocol. Serum total T3 (TT3), TT4, free T3 (FT3), FT4, thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and thyroid-stimulating hormone (TSH) levels were measured using an electrochemiluminescence immunoassay. Routine biochemical and hemogram tests were performed on each sample.Results: Serum RVE1 levels in HT patients (24.09, 15.76-34.38 pg/mL) were significantly lower than those in HCs (28.51, 20.76-51.23 pg/mL) (P=0.027). As the TgAb level increased, the RVE1 content showed a decreasing trend (P for trend=0.001). Multivariable ordinal logistic regression analysis showed that RVE1 was negatively correlated with increasing TgAb in both the unadjusted (OR=0.9446, 95% CI=0.9111-0.9782, P=0.002) and adjusted models (OR=0.9380, 95% CI=0.8967-0.9811, P=0.005).Conclusions: Decreased RVE1 levels indicate impaired resolution of inflammation in HT patients. RVE1 may be a protective factor for elevated TgAb levels.

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The Relationship of TPOAb and TGAb with Risk of Thyroid Nodules: A Large Epidemiological Study

Cited by 17 publications

References 30 publications

Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

The Prevalence of Single and Multiple Thyroid Nodules and Its Association with Metabolic Diseases in Chinese: A Cross-Sectional Study

Serum Resolvin E1 Levels and Its Relationship with Thyroid Autoimmunity in Hashimoto's Thyroiditis

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