The Prevalence of Single and Multiple Thyroid Nodules and Its Association with Metabolic Diseases in Chinese: A Cross-Sectional Study

Zou, Bing Jie; Sun, Li; Wang, Xin; Chen, Zongtao

doi:10.1155/2020/5381012

Cited by 19 publications

(20 citation statements)

References 43 publications

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“…The results of this study show that gender is a non-significant risk factor for thyroid lesions, and its prevalence in women is higher than that in men, which is consistent with the previous reports [19,23]. But other studies [15][16][17] show that gender is an independent risk factor for occurrence of thyroid lesions. The high incidence of thyroid lesions in women is associated with increased demand for thyroid hormones during pregnancy, breastfeeding, and menstruating; estrogen can also affect the development of thyroid nodules [27].…”

Section: Discussionsupporting

confidence: 91%

“…It is also consistent with the findings of Dauksiene et al [24], who studied the factors associated with thyroid nodules in Lithuanian subjects and noted that thyroid nodules represent 31.2%. Other countries have nearly similar prevalence of thyroid nodules (China 32.4% and Korea 34.2%) [15,16]. The patterns of cystic thyroid lesions observed in this study were not comparable with other available literature; cystic thyroid lesion was observed in 6.8% of our participants.…”

Section: Discussioncontrasting

confidence: 88%

“…In our current study, there was a significant relation between age and different thyroid lesions as follows: the median age of subjects diagnosed with thyroiditis was 30 years; solitary nodules occurred during the age of 30-40, which was lower than the age distribution of individuals with solitary thyroid nodules in the study of Bing Zou et al [15], who studied the prevalence of thyroid nodules in Chinese and found that solitary thyroid nodules were most prevalent in the age of 70-89, and also lower than the age distribution of individuals with solitary thyroid nodules in the study of Moon JH, et al [16], who studied the prevalence of thyroid nodules in Koreans and found that solitary thyroid nodules were most prevalent in a mean age of 52.7. In the study conducted by Tu w, et al [17] in China, they reported that nodular lesions were more frequent in population ≥60 years, either diabetic or nondiabetic.…”

Section: Discussioncontrasting

confidence: 55%

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Thyroid Ultrasound Findings and Its Associated Parameters in Saudi People

MM¹,

MA²,

TA³

2021

annalsthyroidres

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Background: Thyroid abnormalities are the most common endocrine abnormalities in Saudi Arabia (KSA). Ultrasonography (USG) is the commonest method of thyroid gland imaging. Thyroid lesions prevalence depends on factors such as sex, age, iodine intake, and other metabolic parameters. Objectives: Investigating different thyroid lesions and their associated clinical parameters. Subjects and Methods: This is a cross-sectional study of adult residents who visited Internal Medicine Clinic in Riyadh, KSA. 206 participants were subjected to thyroid USG, weight and height measurement, laboratory investigations including FBG, HbA1C, ALT, AST, creatinine, uric acid, lipid profile, thyroid stimulating hormone (TSH), and FT4. Results: Thyroid nodules were found in 27.2%, 30.1% had thyroiditis, and 6.8% had pure cysts. There was a significant prevalence of thyroid ultrasound findings within different age groups, (P = 0.002). The highest BMI was found in subjects with nodular size ≤1cm. Subjects with thyroid nodules had higher level of FBG, HbA1c, ALT, AST, uric acid, total cholesterol, HDL-C, LDL-C and TSH. The most frequent thyroid status was euthyroid, followed by subclinical hypothyroidism which had higher frequency in subjects with nodular size ≤1cm (30.8%). Conclusion: Imaging, particularly USG, plays an important role in classifying thyroid gland abnormalities. We found that thyroid lesions, including nodules, pure cysts, and thyroiditis, were non-significantly positively associated with disturbed metabolic profile such as high FBS, HBA1C, ALT, AST, total cholesterol, and LDL levels. Our results for biochemical parameters do not allow inferences on whether they are independent factors associated with thyroid lesions or not.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 88%

Section: Discussioncontrasting

confidence: 55%

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Thyroid Ultrasound Findings and Its Associated Parameters in Saudi People

MM¹,

MA²,

TA³

2021

annalsthyroidres

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“…Moreover, it is partly in line with that in Korea (13.4%) [ 20 ] and Brazil (17.0%) [ 21 ]. Many epidemiological studies [ 22 – 24 ] have presented that the prevalence of thyroid nodules increases with age. The mechanism may be that the thyroid will undergo degenerative changes with age, resulting in development of nodules [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Iodine Status on the Risk of Thyroid Nodules: A Cross-Sectional Study in Zhejiang, China

Lou

Wang

Mao

et al. 2020

International Journal of Endocrinology

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Objective. The aim of this study was to explore whether iodine nutrition is associated with the risk of thyroid nodules among adult population in Zhejiang Province, China. Methods. A cross-sectional study was conducted in the general population aged 18 years or older. A total of 2,710 subjects received physical examination, questionnaires, and thyroid ultrasonography. Urinary iodine concentration (UIC) and thyroid hormone levels were measured and documented for each subject. 4 multiple logistic regression models adjusted for other risk factors were applied to analyze the association between iodine nutrition and thyroid nodules. Results. The prevalence of thyroid nodules was 15.5% among all adults. As indicated by all 4 models, subjects with UIC varying from 200 μg l−1 to 399 μg l−1 had lower risk of thyroid nodules compared with those with relatively low UIC (<100 μg l−1), with approximately 37–57 percent reduction in risk. Moreover, subjects with UIC between 100 and 199 μg l−1 had a decreased risk of thyroid nodules in model 1 and 2 (OR = 0.75, 95% CI, 0.58–0.97; OR = 0.75, 95% CI, 0.58–0.97, respectively). However, there was no significant difference of risk in thyroid nodules between subjects with high UIC (≥400 μg l−1) and low UIC (<100 μg l−1). Furthermore, intake of iodized salt was inversely associated with risk of thyroid nodules, with approximately 69–77 percent reduction in risk. Conclusion. The relationship between UIC and the risk of thyroid nodules is U-shaped. Consumption of noniodized salt is an independent risk factor of thyroid nodules.

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“…2The structure of intrahepatic duct is not clearly displayed. 3The fareld echo of liver is gradually attenuated [17].…”

Section: Diagnosis Of Nafldmentioning

confidence: 99%

Relevance between Helicobacter pylori infection and nonalcoholic fatty liver disease in Bai minority region, Southwestern China

Yu¹,

Li²,

Zhao³

2020

Preprint

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Objective The association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD) remains a matter of debate. We conducted this study to evaluate whether H. pylori infection is a major risk factor for NAFLD. Methods A total of 1185 individuals who received health check-ups from January 2017 to June 2019 were studied. Data of each subject who underwent 13C-urea breath, abdominal ultrasound, neck vascular color doppler ultrasound, and had a complete set of serum biochemical results was collected from the hospital information system. Participants were allocated to NAFLD group and non-NAFLD group based on abdominal color ultrasound for NAFLD. The baseline characteristics and serum biochemical results were compared. Logistic regression analyses were utilized to identify risk factors for NAFLD. Logistic regression models adjusted for confounding factors was performed to investigate the association between H. pylori infection and NAFLD. Results Compared to subjects without NAFLD(n = 656), those with NAFLD (n = 529) were more likely to be older, with higher weight, SBP, DBP, higher levels of TC, TG, LDL-C, FPG, AST and ALT, but with lower levels of HDL-C (all P values < 0.05). The levels of ALT, AST, BMI, FPG, TG, and DBP were independent risk factors for NAFLD (all P values < 0.05). Additionally, H. pylori was also an independent risk factor for NAFLD (OR = 1.35, 95%CI 1.02–1.79, P = 0.036). TC and LDL-C levels were significantly higher in H. pylori-positive group (n = 464) than that of in H. pylori-negative group (n = 721) (all P values < 0.05). Conclusions H. pylori infection is a key risk factor for NAFLD, and serum lipid metabolic dysfunction can be observed in the subjects with H. pylori, suggesting the potential role of H. pylori infection in the progression of NAFLD.

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The Prevalence of Single and Multiple Thyroid Nodules and Its Association with Metabolic Diseases in Chinese: A Cross-Sectional Study

Cited by 19 publications

References 43 publications

Thyroid Ultrasound Findings and Its Associated Parameters in Saudi People

Thyroid Ultrasound Findings and Its Associated Parameters in Saudi People

The Effect of Iodine Status on the Risk of Thyroid Nodules: A Cross-Sectional Study in Zhejiang, China

Relevance between Helicobacter pylori infection and nonalcoholic fatty liver disease in Bai minority region, Southwestern China

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