The relationship of thiol/disulfide homeostasis in the etiology of patients with obstructive sleep apnea: a case-control study

Dikiş, Özlem Şengören; Acat, Murat; Casim, Hasan; Haskul, Ismail; Neşeli̇oğlu, Salim; Şimşek, Abdullah; Erel, Özcan

doi:10.1080/13685538.2019.1573890

Cited by 14 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The level of total thiol is considered as an index of excess free radical generation in both physiological and pathological contexts ( Cadenas, 1989 ). The decreased thiol/disulfide levels for example have recently attracted attention as a biomarker of obstructive sleep apnea which leads to the oxidative stress imbalance and formation of reactive oxygen species in patients ( Sengoren Dikis et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense

Forouzanfar

Gholami

Foroughnia

et al. 2021

Heliyon

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense

Forouzanfar

Gholami

Foroughnia

et al. 2021

Heliyon

View full text Add to dashboard Cite

“…There is a growing body of evidence showing that an abnormal TDH status is associated with the pathogenesis of various diseases. Pathophysiologic role of TDH has been recently studied in a wide range of diseases including coronary artery disease (CAD), 19,20 hypertension, 21 diabetes mellitus, 22,23 chronic renal failure, 8 obesity, 9 ischaemic stroke, 24 pulmonary thromboembolism, 25 respiratory diseases, 7,26 etc. It is thought that this homeostasis plays an important role in the immune etiopathogenesis of the disorders, and disruption of the homeostasis triggers the disease by leading to oxidative stress and tissue inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, dynamic thiol/disulphide homeostasis (TDH) is established. 6–8 Dynamic TDH has important roles in detoxification, apoptosis, antioxidant protection and regulation of enzyme activities and transcription and cellular signal conduction. 8,9 The parameters of dynamic TDH are native thiol (NT), total thiol (TT) and SS, as well as NT/TT, SS/NT and SS/TT ratios.…”

Section: Introductionmentioning

confidence: 99%

Dynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial disease

et al. 2020

View full text Add to dashboard Cite

Objective To examine dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in patients with peripheral arterial disease. Methods One hundred patients with lower extremity peripheral arterial disease (a study group) and 100 control subjects were included in this prospective case–control study. Participants’ baseline clinical characteristics and laboratory data including some oxidant/antioxidant status parameters such as albumin, ferroxidase and myeloperoxidase, and thiol/disulphide homeostasis parameters such as native thiol, total thiol and disulphide, as well as native thiol/total thiol, disulphide/native thiol and disulphide/total thiol ratios were all recorded and then compared between the groups. Results Mean albumin and ferroxidase, and median myeloperoxidase levels were found to be significantly higher in patients with the peripheral arterial disease than in control group ( p = 0.045, p = 0.000 and p = 0.000, respectively). Mean native thiol and total thiol, and median disulphide levels were found to be significantly lower in the study group as compared with the control group ( p = 0.000, p = 0.000 and p = 0.037, respectively). According to the results of logistic regression analysis, systolic blood pressure, ferroxidase and myeloperoxidase levels were detected to be the independent predictors of peripheral arterial disease. Conclusion Our report is the first one in the literature investigating dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in peripheral arterial disease. Dynamic thiol/disulphide homeostasis metrics may be used as a valuable risk factor of oxidative stress in patients with the peripheral arterial disease since it is readily available, easily calculated and relatively cheap.

show abstract

“…It also leads to the development of hypertension, severe cardiac problems, and neurological disorders (1). Oxidative stress, which causes these chronic pathologies, has been shown to play essential roles in OSAS pathogenesis (2).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Polysomnographic Features in Geriatric and Adult Patients

Balcı¹,

Çilekar²

2020

Preprint

View full text Add to dashboard Cite

Objectives: In our study, it was aimed to compare polysomnography features in geriatric and adult patients.Materials and Methods: Our study was conducted as a retrospective case-control study. Sleep Patients who were hospitalized in the polysomnography laboratory with a pre-diagnosis of the disorder were divided into 2 groups according to their age as younger than 65 years old and over. Alice 6 computerized system (Respironics; Philips, Illinois, USA) polysomnography was applied to detect sleep disorders.Results: A total of 500 people, including 180 (36%) women, 320 (64%) men, were included in our study. The mean age was 52.36 ± 13.69. Posittive Airvey Pressure (Pap) treatment rates were significantly higher in the geriatric age group compared to adults. Sleep efficiency, mean sleep time, and total sleep time were higher in adults compared to geriatric patients. In the geriatric patient group, the most common diagnosis as a result of PSG was the diagnosis of Severe OSAS with 84 (%) people. When the lower extremity mobility measurements during sleep were evaluated, the values were found to be significantly higher in geriatric patients with severe OSAS. Stage 3 and Rem stage were significantly higher in adults in terms of NREM3 (%) and REM (%) measurements.Conclusion: Sleep times are reduced in geriatric patients, restless leg movements during sleep are more common than adult patients, and sleep-disordered breathing is generally more severe in geriatric patients.

show abstract

The relationship of thiol/disulfide homeostasis in the etiology of patients with obstructive sleep apnea: a case-control study

Cited by 14 publications

References 28 publications

The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense

The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense

Dynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial disease

Comparison of Polysomnographic Features in Geriatric and Adult Patients

Contact Info

Product

Resources

About