The Relationship of Single Nucleotide Polymorphisms in the <i>TRPV1</i> Gene with Lipid Profile, Glucose, and Blood Pressure in Mexican Population

González-Mercado, Anahí; Magaña-Torres, María Teresa; Sánchez-López, Josefina Yoaly; Ríos-Silva, Mónica; Ibarra-Cortés, Bertha; Trujillo, Xóchitl; Huerta, Miguel

doi:10.1089/gtmb.2019.0213

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…The role of many genetic variations in relation to lipid levels has already extensively been studied [ 12 , 35 , 36 ]. GWAS studies revealed that SNPs in the LPL are associated with levels of cholesterol, triglycerides, and more, as well as numerous molecular phenotypes are related to human diseases and diseases risk [ 6 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, to increase the understanding of the interaction between LPL, PPARγ, and FNDC5 genes with lipid metabolic profile as well as body composition parameters, under non-pathological conditions, we have thoroughly evaluated the presence of novel and already discovered SNPs and their potential associations in young adolescents. The role of many genetic variations in relation to lipid levels has already extensively been studied [12,35,36]. GWAS studies revealed that SNPs in the LPL are associated with levels of cholesterol, triglycerides, and more, as well as numerous molecular phenotypes are related to human diseases and diseases risk [6,37,38].…”

Section: Discussionmentioning

confidence: 99%

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LPL, FNDC5 and PPARγ gene polymorphisms related to body composition parameters and lipid metabolic profile in adolescents from Southern Italy

et al. 2022

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Background Plasma lipid profile and anthropometric variables are known to be under strong genetic control and the identification of genetic variants associated with bioclinical parameters is of considerable public health importance. In this study, a young cohort of healthy individuals was genotyped for genes related to health and pathological conditions, to analyze the association of single nucleotide polymorphisms (SNPs) with different bioclinical parameters, adherence to the Mediterranean Diet (MD) and physical activity, studying the role of lifestyle and body composition parameters on biochemical metabolic profile. Methods Association analysis of single variants in the genes of lipoprotein lipase (LPL), fibronectin type III domain containing protein 5 (FNDC5), and peroxisome proliferator-activated receptor-gamma (PPARγ) and haplotype analyses were performed. Results Multiple (n = 14) common variants in the three genes demonstrated a significant effect on plasma lipoprotein-lipid levels and/or on biochemical parameters in our sample. Specifically, SNPs were related to lipid metabolism (rs3866471, rs4922115, rs11570892, rs248, rs316, rs1059507, rs1801282) or glycemic profile (rs3208305) or anthropometric parameters (rs3480, rs726344, rs1570569) for a total of 26 significant associations (P < 0.01 and/or P < 0.05) and two haplotypes, for the first time, were strongly associated with lipid and body composition parameters. Interestingly, we identified twenty-four new variants not previously described in the literature and a novel significant association between rs80143795 and body composition. Conclusions In this study we confirm the association between these SNPs on lipid metabolism and body parameters also in a young cohort, indicating the important role of these genetic factors as determinants of health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

LPL, FNDC5 and PPARγ gene polymorphisms related to body composition parameters and lipid metabolic profile in adolescents from Southern Italy

et al. 2022

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“…Genetic factors have been associated with the TRPV1 gene polymorphism, leading to an increased risk of developing hypertension and dyslipidemia [253][254][255]. However, environmental factors, including air pollution, can influence cardiovascular function.…”

Section: Transient Receptor Potential Vanilloid Typementioning

confidence: 99%

Targeting temperature-sensitive transient receptor potential channels in hypertension: far beyond the perception of hot and cold

Jesus

Araujo

Alves

et al. 2023

Journal of Hypertension

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Transient receptor potential (TRP) channels are nonselective cation channels and participate in various physiological roles. Thus, changes in TRP channel function or expression have been linked to several disorders. Among the many TRP channel subtypes, the TRP ankyrin type 1 (TRPA1), TRP melastatin type 8 (TRPM8), and TRP vanilloid type 1 (TRPV1) channels are temperature-sensitive and recognized as thermo-TRPs, which are expressed in the primary afferent nerve. Thermal stimuli are converted into neuronal activity. Several studies have described the expression of TRPA1, TRPM8, and TRPV1 in the cardiovascular system, where these channels can modulate physiological and pathological conditions, including hypertension. This review provides a complete understanding of the functional role of the opposing thermo-receptors TRPA1/TRPM8/TRPV1 in hypertension and a more comprehensive appreciation of TRPA1/TRPM8/TRPV1-dependent mechanisms involved in hypertension. These channels varied activation and inactivation have revealed a signaling pathway that may lead to innovative future treatment options for hypertension and correlated vascular diseases.

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“… González-Mercado et al (2020) showed a possible relationship between TRPV1 gene polymorphisms and blood pressure and lipid profiles in a Mexican population. They showed that rs222747CC genotype, found in domain 5 containing ankyrin repeats, was associated with lower low density lipoprotein (LDL) levels, whereas rs224534AA genotype, located on the extracellular loop between helices 1 and 2, was associated with higher high density lipoprotein (HDL) levels and lower triglycerides and LDL ( González-Mercado et al, 2020 ). Recently, the metabolic differences in plasma and skin between two female mice groups treated with or without capsaicin were studied.…”

Section: Introductionmentioning

confidence: 97%

The interaction of TRPV1 and lipids: Insights into lipid metabolism

et al. 2022

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Transient receptor potential vanilloid 1 (TRPV1), a non-selective ligand-gated cation channel with high permeability for Ca2+, has received considerable attention as potential therapeutic target for the treatment of several disorders including pain, inflammation, and hyperlipidemia. In particular, TRPV1 regulates lipid metabolism by mechanisms that are not completely understood. Interestingly, TRPV1 and lipids regulate each other in a reciprocal and complex manner. This review surveyed the recent literature dealing with the role of TRPV1 in the hyperlipidemia-associated metabolic syndrome. Besides TRPV1 structure, molecular mechanisms underlying the regulatory effect of TRPV1 on lipid metabolism such as the involvement of uncoupling proteins (UCPs), ATP-binding cassette (ABC) transporters, peroxisome proliferation-activated receptors (PPAR), sterol responsive element binding protein (SREBP), and hypoxia have been discussed. Additionally, this review extends our understanding of the lipid-dependent modulation of TRPV1 activity through affecting both the gating and the expression of TRPV1. The regulatory role of different classes of lipids such as phosphatidylinositol (PI), cholesterol, estrogen, and oleoylethanolamide (OEA), on TRPV1 has also been addressed.

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The Relationship of Single Nucleotide Polymorphisms in the TRPV1 Gene with Lipid Profile, Glucose, and Blood Pressure in Mexican Population

Cited by 5 publications

References 18 publications

LPL, FNDC5 and PPARγ gene polymorphisms related to body composition parameters and lipid metabolic profile in adolescents from Southern Italy

LPL, FNDC5 and PPARγ gene polymorphisms related to body composition parameters and lipid metabolic profile in adolescents from Southern Italy

Targeting temperature-sensitive transient receptor potential channels in hypertension: far beyond the perception of hot and cold

The interaction of TRPV1 and lipids: Insights into lipid metabolism

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