Targeting temperature-sensitive transient receptor potential channels in hypertension: far beyond the perception of hot and cold

Abstract

Transient receptor potential (TRP) channels are nonselective cation channels and participate in various physiological roles. Thus, changes in TRP channel function or expression have been linked to several disorders. Among the many TRP channel subtypes, the TRP ankyrin type 1 (TRPA1), TRP melastatin type 8 (TRPM8), and TRP vanilloid type 1 (TRPV1) channels are temperature-sensitive and recognized as thermo-TRPs, which are expressed in the primary afferent nerve. Thermal stimuli are converted into neuronal activity. Several studies have described the expression of TRPA1, TRPM8, and TRPV1 in the cardiovascular system, where these channels can modulate physiological and pathological conditions, including hypertension. This review provides a complete understanding of the functional role of the opposing thermo-receptors TRPA1/TRPM8/TRPV1 in hypertension and a more comprehensive appreciation of TRPA1/TRPM8/TRPV1-dependent mechanisms involved in hypertension. These channels varied activation and inactivation have revealed a signaling pathway that may lead to innovative future treatment options for hypertension and correlated vascular diseases.

Role of TRP Channels in Metabolism-Related Diseases

“…Upon administering treatment to 16-week-old SHR rats, the findings indicated that the RTX intervention group elicited a significant reduction in mean arterial pressure when compared to the carrier control group [27]. Furthermore, the thermosensitive receptors, TRPA1/TRPM8/TRPV1, which are expressed in the cardiovascular system, have been implicated in the pathogenesis of hypertension [186]. The distinct activation and deactivation processes of these channels suggest a potential signaling pathway that could pave the way for the development of novel therapeutic strategies for hypertension and associated vascular disorders in the future.…”