The relationship of serum uric acid to risk factors in coronary heart disease

Myers, Allen R.; Epstein, Frederick H.; Dodge, Horace J.; Mikkelsen, William M.

doi:10.1016/0002-9343(68)90168-x

Cited by 143 publications

(37 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…24 Therefore, our results are compatible with many other clinical and epidemiological studies. [1][2][3][4]25 In addition, our study showed no significant interactive effect of MTHFR mutation and serum UA level with BP (MBP, SBP, or DBP), even after multiple adjustment for age, BMI, daily smoking, alcohol consumption, physical activity, animal protein intake, serum creatinine, serum folate, and serum vitamin B12. To the best of our knowledge, gene -UA interaction or gene -lifestyle interaction related to MTHFR polymorphisms in the general Japanese population has not been previously reported.…”

Section: Discussionmentioning

confidence: 91%

Polymorphism of Methylenetetrahydrofolate Reductase Gene (C677T MTHFR) is Not a Confounding Factor of the Relationship Between Serum Uric Acid Level and the Prevalence of Hypertension in Japanese Men

Lwin¹,

Yokoyama²,

Yoshiike³

et al. 2006

Circ J

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 91%

Polymorphism of Methylenetetrahydrofolate Reductase Gene (C677T MTHFR) is Not a Confounding Factor of the Relationship Between Serum Uric Acid Level and the Prevalence of Hypertension in Japanese Men

Lwin¹,

Yokoyama²,

Yoshiike³

et al. 2006

Circ J

View full text Add to dashboard Cite

“…In contrast to the currently available diuretics which induce hyperuricemia, a high-risk factor in cardiovascular disease [14][15][16][17][18][19][20], tienilic acid is a new diuretic with marked uricosuric activity in man [1,21,22]. Its natriuretic effect is similar to that of the thiazides [1.4.…”

Section: Discussionmentioning

confidence: 99%

The Renal Handling of Tienilic Acid (Ticrynafen), a New Diuretic with Uricosuric Properties

Lemieux¹,

Vinay²,

Paquin³

et al. 1979

Nephron

View full text Add to dashboard Cite

Tienilic acid (ticrynafen) [2,3-dichloro-4-(2-thyenil-carbonyl) phenoxyacetic acid] is a new diuretic with uricosuric properties in man and dog. In this animal the drug acts by blocking tubular transport of uric acid in the proximal tubule. We have demonstrated that tienilic acid (TA) is highly bound to plasma proteins at 37 ¤C (more than 95% at drug concentrations of 3.0–20.0 mg/dl). Thus, glomerular filtration of the drug is negligible and tienilic acid must reach the kidney at the antiluminal site of the tubule. During free-flow studies, the clearance of tienilic acid at stable plasma concentrations ranging from 3.0 to 20.0 mg/dl ranged from 11 to 22% of glomerular filtration measured by exogenous creatinine clearance. These values are 3–5 times greater than that accounted for by filtration of the drug alone and are highly suggestive of tubular secretion. Secretion becomes more apparent during alkalinization of the urine when the clearance of tienilic acid may rise to 40 and even 100% of glomerular filtration. During stop-flow studies, the urine over plasma ratio of the drug (U/P TA) over that of creatinine (U/P Cr) decreased along the nephron indicating progressive reabsorption. At equivalent plasma concentration, it was demonstrated that tienilic acid markedly depresses PAH transport in the proximal tubule. When plasma tienilic acid concentration is kept low (5 mg/dl) and PAH concentration is raised to 30 mg/dl, the (U/P TA)/(U/P Cr) drops by 50%. Our results indicate active secretion of tienilic acid in the proximal tubule followed by passive pH dependent reabsorption along the nephron. The drug is transported through the common organic acid pathway by a carrier having higher affinity for tienilic acid than for PAH.

show abstract

“…Correlation between hyperuricemia, metabolic arthritis and type 2 diabetes was observed by Berowitz and Mikkelson [17,18]. In the other publications this correlation wasn't confirmed [19,20]. Yano, Klein, Hermann and associates informed about negative correlation between level of uric acid in serum and diabetes [21][22][23].…”

Section: Discussionmentioning

confidence: 98%

The concentration of uric acid in patients with metabolic syndrome and cardiovascular diseases

et al. 2009

View full text Add to dashboard Cite

AbstractThe association of elevated serum uric acid (hyperuricemia, gout) with the presence of classical coronary risk factors and coronary artery disease (CAD) or myocardial infarction (MI) has been analysed in many epidemiological studies. Numerous studies have revealed that hypertension, high body mass index (BMI), lipid disorders (especially raised triglyceride (TG) levels and low high dense lipoprotein cholesterol (HDL-C) level), and increased creatinine or insulin levels have caused hyperuricemia. Gout has often occurred with typical disorders for the metabolic syndrome X. Significant correlation of the serum uric level and the CAD presence and severity of coronary atherosclerosis confirmed by coronary angiography has been observed in women. Hyperuricemia has also indirect influence on progress of CAD by physical activity restriction, what causes sedentary mode of life and lead to obesity. Therefore, we conducted our study in order to estimate uric acid levels in patients with metabolic syndrome and coexisting cardiovascular system diseases.

show abstract

The relationship of serum uric acid to risk factors in coronary heart disease

Cited by 143 publications

References 38 publications

Polymorphism of Methylenetetrahydrofolate Reductase Gene (C677T MTHFR) is Not a Confounding Factor of the Relationship Between Serum Uric Acid Level and the Prevalence of Hypertension in Japanese Men

Polymorphism of Methylenetetrahydrofolate Reductase Gene (C677T MTHFR) is Not a Confounding Factor of the Relationship Between Serum Uric Acid Level and the Prevalence of Hypertension in Japanese Men

The Renal Handling of Tienilic Acid (Ticrynafen), a New Diuretic with Uricosuric Properties

The concentration of uric acid in patients with metabolic syndrome and cardiovascular diseases

Contact Info

Product

Resources

About