The Relationship of Serum Lipoprotein Lipase Mass with Fasting Serum Apolipoprotein B-48 and Remnant-like Particle Triglycerides in Type 2 Diabetic Patients

Kobayashi, Junji; Nakajima, Katsuyuki; Nohara, Atsushi; Kawashiri, Masa‐aki; Yagi, Kunimasa; Inazu, Akihiro; Koizumi, Junji; Yamagishi, Minoru; Mabuchi, Hiroshi

doi:10.1055/s-2007-984473

Cited by 9 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decreased LPL activity accounts for a great deal of the elevation of serum TG in insulin-deficient diabetes patients [19, 20]. As the RLP-TG to TG ratio has been reported to correlate with LPL activity [21], the result of a significant and positive relationship between RBP4 and the RLP-TG to TG ratio in this study suggests that decreased LPL activity would have contributed much to the elevation of RLP-TG.…”

Section: Discussionmentioning

confidence: 56%

Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus

Yamaaki

Yagi

Kobayashi

et al. 2013

Journal of Diabetes Research

View full text Add to dashboard Cite

Background. Although retinol-binding protein 4 (RBP4) associates with insulin resistance and remnant-like particles triglyceride (RLP-TG) elevated in the insulin resistant state, few data exist regarding the relationship between RBP4 and RLP-TG. Subjects and Methods. The study included 92 Japanese type 2 diabetic mellitus (T2DM) male patients (age 60.5 ± 13.6 years, body mass index (BMI) 24.7 ± 4.1 kg/m2, waist circumference (WC) 88.4 ± 10.7 cm, and HbA1c (NGSP) 7.2 ± 1.9%). Patients on medications affecting insulin sensitivity, including fibrates, biguanides, and thiazolidinedione, were excluded. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by computed tomography. Results. RBP4 levels showed a significant positive correlation with RLP-TG (r = 0.2544 and P = 0.0056), TG (r = 0.1852 and P = 0.041), RLP-TG/TG (r = 0.23765 and P = 0.0241), and age (r = −0.2082 and P = 0.0219), although there was no significant correlation with VFA, SFA, adiponectin levels, or homeostasis model of assessment insulin resistance (HOMA-R). Multiple regression analysis revealed that RBP4 was an independent determinant of RLP-TG (P = 0.0193) but was not a determinant of TG. Conclusions. RBP4 correlates positively with serum RLP-TG independent of fat accumulation in T2DM. RBP4 may regulate remnant metabolism independent of glycemic control in T2DM.

show abstract

Section: Discussionmentioning

confidence: 56%

Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus

Yamaaki

Yagi

Kobayashi

et al. 2013

Journal of Diabetes Research

View full text Add to dashboard Cite

show abstract

“…From the point at which cilostazol treatment does not signifi cantly change the plasma apoAI level, cholesterol effl ux from peripheral tissues via the apoAI-ABCA1 pathway may be promoted. Further studies including the effects on lipoprotein lipase protein mass and activity [33,34] are needed to clarify the mechanisms of cilostazol ' s effect on HDL-C metabolism and its relationship with the antiatherogenic effects exhibited in this study. Recently, the development of torcetrapib, a CETP inhibitor, that signifi cantly upregulated plasma HDL-C-levels was discontinued after an increase in the mortality rate was observed after administration of torcetrapib [35] .…”

Section: Resultsmentioning

confidence: 98%

Antiatherogenic Effects of Cilostazol and Probucol Alone, and in Combination in Low Density Lipoprotein Receptor-deficient Mice Fed with a High Fat Diet

Yoshikawa¹,

Mitani²,

Kotosai³

et al. 2008

Horm Metab Res

View full text Add to dashboard Cite

Cilostazol, an antiplatelet drug, and probucol, a cholesterol-lowering drug, are reported to ameliorate atherosclerosis in animal models. However, their combined effect on atherosclerosis is unclear. We therefore evaluated their combined effect on atherosclerotic lesions in LDL receptor-deficient mice. Male LDL receptor-deficient mice were fed a high fat diet with or without cilostazol alone, probucol alone, or with cilostazol and probucol in combination, for 8 weeks. Body weight and plasma lipid levels were measured before and during treatment. At the end of treatment, the size distribution of plasma lipoproteins was analyzed by HPLC and then plasma HDL cholesterol levels and en face aortic atherosclerotic lesion areas were measured. Probucol alone significantly decreased both total cholesterol and HDL cholesterol, while cilostazol alone did not decrease total cholesterol, but significantly increased HDL cholesterol. Both cilostazol alone and probucol alone significantly decreased atherosclerotic lesion areas, and their combined administration showed more significant decreases than when each drug was administered singly. The combination of cilostazol and probucol was more effective in preventing atherosclerotic lesion formation than the administration of each drug alone; this may provide us with a new strategy for treating atherosclerosis.

show abstract

“…6 From these results, we investigated if ANGPTL3 really regulates TG-rich lipoprotein metabolism through inhibiting LPL and HTGL activities in human plasma as in mice. LPL has been known to hydrolyse chylomicrons and very low-density lipoproteins (VLDL) to form their remnants in human plasma, 7,8 and HTGL has been known to hydrolyse b-VLDL or intermediate density lipoproteins (IDL) to form small, dense LDL (sd LDL). 9 HTGL is also known to hydrolyse TG in LDL and HDL, especially to hydrolyse HDL2 to form HDL3.…”

Section: Introductionmentioning

confidence: 99%

Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma

et al. 2010

View full text Add to dashboard Cite

show abstract

The Relationship of Serum Lipoprotein Lipase Mass with Fasting Serum Apolipoprotein B-48 and Remnant-like Particle Triglycerides in Type 2 Diabetic Patients

Abstract: The decrease in LPL protein mass could cause an increase in serum apo B-48 and RLP-TG levels, which is related to the retardation of remnant metabolism.

Cited by 9 publications

References 15 publications

Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus

Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus

Antiatherogenic Effects of Cilostazol and Probucol Alone, and in Combination in Low Density Lipoprotein Receptor-deficient Mice Fed with a High Fat Diet

Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma

Contact Info

Product

Resources

About