Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus

Yamaaki, Naoto; Yagi, Kunimasa; Kobayashi, Junji; Nohara, Atsushi; Ito, Naoko; Asano, Akimichi; Nakano, Kaoru; Liu, Jianhui; Okamoto, Takuya; Mori, Yoshio; Ohbatake, Azusa; Okazaki, S.; Takeda, Yoshiyu; Yamagishi, Masakazu

doi:10.1155/2013/143515

Cited by 10 publications

(6 citation statements)

References 23 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[9] The correlation between TG and RBP4 concentrations may be related to the correlations that we observed between RBP4 concentration and the obesity markers (WHR and WC) which are why TG has been considered a marker for central obesity. [29] These findings were in line with Graham et al . and Takebayashi et al .…”

Section: Discussionsupporting

confidence: 90%

Association of retinol-binding protein 4 with metabolic syndrome in first-degree relatives of type 2 diabetic patients

et al. 2017

View full text Add to dashboard Cite

Background:Retinol-binding protein 4 (RBP4) is known to regulate lipid and glucose metabolism and insulin resistance. The influences of RBP4 on metabolic syndrome (MS) are still unclear. The purpose of this study is to evaluate the association between serum levels of RBP4 and MS components in first-degree relations of type 2 diabetic patients.Materials and Methods:This cross-sectional study was performed within the framework of the diabetes prevention project in Isfahan. This study has been conducted during 2012–2013. Seventy-eight subjects participate, with an average age of 43.20 ± 5.29 years. Weight, height, waist and hip circumferences, blood pressure (BP) of participants, fasting plasma glucose, hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol, triglyceride (TG), and serum RBP4 were measured from fasting blood sample taken from each participant after an overnight fast (12–14 h).Results:Systolic and diastolic BP were significantly higher in people in top median of RBP4 (11.8 ± 1.5 vs. 11.0 ± 1.2, P = 0.01 and 7.8 ± 1.0 vs. 7.3 ± 0.9, P = 0.03). Moreover, TG in people with high levels of RBP4 was higher compared with those with low levels of RBP4 (177.7 ± 97.6 vs. 138.7 ± 56.9, P = 0.02). People with low levels of RBP4 had significant greater hip circumferences (107.9 ± 7.5 vs. 104.3 ± 8.0, P = 0.04). There was no correlation between RBP4 and MS in crude model (odds ratio [OR]: 1.00, 0.95–1.05, P = 0.97). This null correlation remained after adjustment for body mass index, age, and physical activity (OR: 0.93, 0.91–1.07, P = 0.31).Conclusion:Although RBP4 levels were positively association with some risk factors of MS including hip circumference, TG, and systolic and diastolic BP, it does not seem to be a valuable marker for identification of the MS in the first relative degree of diabetic patients.

show abstract

Section: Discussionsupporting

confidence: 90%

Association of retinol-binding protein 4 with metabolic syndrome in first-degree relatives of type 2 diabetic patients

et al. 2017

View full text Add to dashboard Cite

show abstract

“…44,45 This is possibly the major reason for the moderate liver uptake of the vitamin A modified nanocomplex in the rats with liver fibrosis (Figure 8). On the other hand, other retinol-binding proteins also exist in hepatocytes and serum, 46–48 which may limit the specificity of vitamin A to HSCs. Our biodistribution study revealed moderate uptake of the vitamin A coupled nanocomplex in the liver but also nonspecific uptake in the lung and kidney (Figure 8).…”

Section: Discussionmentioning

confidence: 99%

Development of a peptide-modified siRNA nanocomplex for hepatic stellate cells

Zhao

Jain

et al. 2018

Nanomedicine: Nanotechnology, Biology and Medicine

View full text Add to dashboard Cite

Insulin-like growth factor 2 receptor (IGF2R) is overexpressed in activated hepatic stellate cells (HSCs) and therefore can be utilized for HSC-specific drug delivery. We recently discovered an IGF2R-specific peptide using a novel biopanning. Here, we adopted biotin-conjugated IGF2R-specific peptide, cholesterol, and vitamin A as the targeting ligands for the neutravidin-based siRNA nanocomplex to deliver PCBP2 siRNA, a potentially antifibrotic agent, to HSCs. Compared to vitamin A and cholesterol, the IGF2R-specific peptide exhibited the highest targeting effect to human LX-2 HSC, rat HSC-T6 cell line, and activated primary rat HSCs. Accordingly, the IGF2R-specific peptide coupled nanocomplex demonstrated higher silencing activity of PCBP2 and better inhibition on the migration of activated HSCs. Compared to free siRNA and the nanocomplexes coupled with vitamin A and cholesterol, the IGF2R-specific peptide coupled nanocomplex showed the highest uptake in the liver and lowest uptake in the lung and kidney of the rats with CCl-induced liver fibrosis.

show abstract

“…As far as we know this is one of the preliminary studies to demonstrate a stronger association of this adipokine with raised triglycerides in Asian Indian men. Plausible mechanistic link could be due to the production of triglycerides in the liver and release of very low-density lipoprotein into the circulation lead to an insulin-resistant state, and this may also partially explain the close association between RBP4, triglycerides, and insulin resistance [5,7,10,11,[23][24][25]. However, a few studies failed to show an association between RBP4 and insulin resistance [13,15].…”

Section: Discussionmentioning

confidence: 99%

Retinol binding protein‐4 predicts incident diabetes in Asian Indian men with prediabetes

et al. 2015

View full text Add to dashboard Cite

The association of retinol binding protein-4 (RBP4) with incident type 2 diabetes (T2DM) in Asian Indian middle-aged men with impaired glucose tolerance (IGT) was studied. This was an ancillary analysis of a subsample from a cohort of participants with IGT in a 2 year prospective diabetes prevention program in India. For this analysis, 71 incident T2DM and 76 non-diabetic cases (non-progressors) based on the final glycemic outcome were selected. Baseline serum RBP4 was measured using competitive enzyme immunoassay. Correlations of RBP4 with relevant anthropometric and biochemical variables and also its association with diabetes were assessed using appropriate statistical analyses. Participants who developed T2DM had higher levels of serum RBP4 (21.3 [IQR: 17.7-24.9] µg/mL) compared with non-progressors (17.3 [IQR: 13.1-21.0] µg/mL; P = 0.001). Levels of RBP4 were lower than in Caucasians. Stepwise linear regression analysis showed that body mass index (BMI), systolic blood pressure, triglycerides, and HbA1c had independent associations with RBP4 levels. Multiple logistic regression analyses showed that RBP4 was independently associated with incident diabetes (odds ratio [OR] [95%confidence interval (CI)]: 1.69 [1.18-2.41]; P = 0.004). Adjustment for study group, age, BMI, waist circumference, 2 H plasma glucose, triglycerides, gamma glutamyl transferase, and insulin resistance weakened the significance of its association (OR [95%CI]: 1.65 [1.03-2.66]; P = 0.038).The results of this preliminary analyses showed that baseline serum RBP4 levels were independently associated with incident diabetes in Asian Indian men with IGT. It may be used as an additional predictor of future diabetes.

show abstract

Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus

Cited by 10 publications

References 23 publications

Association of retinol-binding protein 4 with metabolic syndrome in first-degree relatives of type 2 diabetic patients

Association of retinol-binding protein 4 with metabolic syndrome in first-degree relatives of type 2 diabetic patients

Development of a peptide-modified siRNA nanocomplex for hepatic stellate cells

Retinol binding protein‐4 predicts incident diabetes in Asian Indian men with prediabetes

Contact Info

Product

Resources

About