The Relationship of Mean Defect to Corrected Loss Variance in Glaucoma and Ocular Hypertension

Pa, Pearson; Lb, Baldwin; Tj, Smith

doi:10.1159/000310072

Cited by 8 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In early and moderate glaucomas, there is a linear relationship between the sLV and the MD (28). These results confirm previous reports that sLV and MD are better correlated in TOP than in FT (8).…”

Section: Discussionsupporting

confidence: 90%

Diagnostic Accuracy and Reproducibility of Tendency Oriented Perimetry in Glaucoma

Rosa

González-Hernández

Feijoó

et al. 2006

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose To evaluate the diagnostic capability of tendency oriented perimetry (TOP) in glaucoma. Methods A): The diagnostic accuracy of mean defect (MD), square-root of the loss variance (sLV), and number of pathologic points (NPP) was calculated in 295 normal and 414 glaucoma eyes (179 early, 112 moderate, and 123 advanced) examined with TOP. B): Threshold fluctuation (F) and its relationship with the loss variance (LV) was measured in 34 normal and 33 glaucoma eyes (mean MD=3 dB; SD=3.9) for TOP and for full-threshold perimetry (FT). C): Twenty-eight eyes with stable glaucoma (mean MD=9.5 dB; SD=7.2) were examined six times to quantify LV error. D): TOP and FT were tested with the simulation program PeriSim using different behavior models. Results A): The best diagnostic index in early glaucoma (MD<6dB) was sLV(specificity=90.2%, sensitivity=84.9). The three indices had similar precision in moderate and severe glaucoma. B): Threshold fluctuation and sLV were better correlated in TOP (r=0.72, p<0.01) than in FT (r=0.62, p<0.01). For normal subjects, in FT the incidence of F<2 dB was 8.82% and sLV<1.5 dB 5.88%. The same frequencies in TOP were 67.65% and 55.88%. C): Averaging six examinations reduced the sLV value by 22%. D): The threshold estimation error increased 1 dB in TOP in relation to FT for the same patient's behavior, but the error in TOP was lower than in FT when the worst behavior was modeled. Conclusions TOP is a good discriminator between glaucoma and normality. Perimetry results overestimate the real sLV value. TOP's high diagnostic ability is probably associated to the algorithm design and to less contaminating influences during the examination.

show abstract

Section: Discussionsupporting

confidence: 90%

Diagnostic Accuracy and Reproducibility of Tendency Oriented Perimetry in Glaucoma

Rosa

González-Hernández

Feijoó

et al. 2006

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…2 15 LF progressively increased from stage 0 to stage 4, reached a plateau for MD of about −13 dB and then decreased when the glaucoma defect became more diffuse (stage 5 had CI similar to stage 1). This curve resembles the curvilinear relation between MD and PSD described by Pearson et al ,16 because they share at least two common determining factors.…”

Section: Discussionsupporting

confidence: 73%

Long-term perimetric fluctuation in patients with different stages of glaucoma

Fogagnolo

Sangermani

Oddone

et al. 2010

British Journal of Ophthalmology

View full text Add to dashboard Cite

“…This may be linked to these two factors or to the better correlation between MD and sLV with the TOP strategy than with SB. The relation between both indices has been described (21), indicating that the increase of fluctuation and the irregularity of the visual field are direct-ly linked to the progression of most of the abnormalities.…”

Section: Discussionmentioning

confidence: 98%

Multicenter Evaluation of Tendency-Oriented Perimetry (TOP) Using the G1 Grid

Rosa

Morales

Dannheim

et al. 2003

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose The G1-TOP program is a short automated perimetric strategy which sub-divides the G1 grid of 59 points into four sub-grids. Each point is tested only once, but each patient's response is used to modify that particular point and the surrounding ones from the remaining sub-grids. This study compared the results of the G1-TOP program with the Standard Bracketing strategy. Methods Eleven participating institutions provided data from 213 patients (406 eyes). The main group consisted of 284 glaucomas and 55 glaucoma suspects. Other groups included 31 eyes with neurological disorders, 20 with chorioretinal lesions and 16 normal eyes. Mean age was 62.7 ± 15.4 (range 14–88) years. All subjects had previous perimetric experience and visual acuity better than 0.5. Examination included G1-Standard Bracketing and G1-TOP testing, in interchangeable order, with the Octopus 1-2-3 perimeter. Results The correlation coefficient for mean defect (MD) was 0.95. Standard error (YX) for MD, square root of loss variance (LV) and individual thresholds were 1.86 dB, 1.29 dB, and 4.72 dB, respectively. Mean sensitivity values were similar (difference 0.04 ± 1.87 dB) (p>0.05). Mean duration for G1-TOP was 2.19 ± 0.26 min, while G1-Standard Bracketing took 11.51 ± 1.52 min (ratio 1/5.1, or a net reduction of 80.4%). The sensitivity of G1-TOP versus G1-Standard Bracketing was: glaucoma 77.1/78.5, glaucoma suspects 38.2/47.3, neurological disorders 87.1/87.1 and chorioretinal lesions 80.0/85.0. Conclusions The G1-TOP program gave very similar results to G1-Standard Bracketing in only 20% of the time required by the standard strategy.

show abstract

The Relationship of Mean Defect to Corrected Loss Variance in Glaucoma and Ocular Hypertension

Cited by 8 publications

References 3 publications

Diagnostic Accuracy and Reproducibility of Tendency Oriented Perimetry in Glaucoma

Diagnostic Accuracy and Reproducibility of Tendency Oriented Perimetry in Glaucoma

Long-term perimetric fluctuation in patients with different stages of glaucoma

Multicenter Evaluation of Tendency-Oriented Perimetry (TOP) Using the G1 Grid

Contact Info

Product

Resources

About