Long-term perimetric fluctuation in patients with different stages of glaucoma

Fogagnolo, Paolo; Sangermani, C.; Oddone, Francesco; Frezzotti, Paolo; Iester, Michele; Figus, Michele; Ferreras, Antonio; Romano, Simona; Gandolfi, Stefano; Centofanti, Marco; Rossetti, Luca; Orzalesi, N.

doi:10.1136/bjo.2010.182758

Cited by 31 publications

(22 citation statements)

References 16 publications

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“…However, visual field series from individual patients can differ substantially from each other. [5][6][7] Therefore, when populationbased criteria are used to define change, some patients are much more likely to produce a false-positive result than others (e.g., Artes PH, et al IOVS 2011; 52:ARVO E-Abstract 4148).…”

Section: Resultsmentioning

confidence: 99%

Visual Field Progression in Glaucoma: Estimating the Overall Significance of Deterioration with Permutation Analyses of Pointwise Linear Regression (PoPLR)

O’Leary¹,

Chauhan²,

Artes³

2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To establish a method for estimating the overall statistical significance of visual field deterioration from an individual patient's data, and to compare its performance to pointwise linear regression.METHODS. The Truncated Product Method was used to calculate a statistic S that combines evidence of deterioration from individual test locations in the visual field. The overall statistical significance (P value) of visual field deterioration was inferred by comparing S with its permutation distribution, derived from repeated reordering of the visual field series. Permutation of pointwise linear regression (PoPLR) and pointwise linear regression were evaluated in data from patients with glaucoma (944 eyes, median mean deviation À2.9 dB, interquartile range: À6.3, À1.2 dB) followed for more than 4 years (median 10 examinations over 8 years). Falsepositive rates were estimated from randomly reordered series of this dataset, and hit rates (proportion of eyes with significant deterioration) were estimated from the original series. RESULTS.The false-positive rates of PoPLR were indistinguishable from the corresponding nominal significance levels and were independent of baseline visual field damage and length of follow-up. At P < 0.05, the hit rates of PoPLR were 12, 29, and 42%, at the fifth, eighth, and final examinations, respectively, and at matching specificities they were consistently higher than those of pointwise linear regression. CONCLUSIONS.In contrast to population-based progression analyses, PoPLR provides a continuous estimate of statistical significance for visual field deterioration individualized to a particular patient's data. This allows close control over specificity, essential for monitoring patients in clinical practice and in clinical trials. (Invest Ophthalmol Vis Sci. 2012; 53:6776-6784)

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Section: Resultsmentioning

confidence: 99%

Visual Field Progression in Glaucoma: Estimating the Overall Significance of Deterioration with Permutation Analyses of Pointwise Linear Regression (PoPLR)

O’Leary¹,

Chauhan²,

Artes³

2012

Invest. Ophthalmol. Vis. Sci.

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“…Very recently, we also showed that long-term fluctuation depends on the GSS stage. 23 In order to protect our study from this potential problem, we chose a homogeneous sample of patients having GSS ¼ 4. On the other hand, this could be a potential limiting factor because the relationship between morphological and functional changes induced by trabeculectomy might have different patterns at varying stages of the disease.…”

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 99%

Short-term changes in the optic nerve head and visual field after trabeculectomy

Figus

Lazzeri

Nardi

et al. 2011

Eye

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Aims or Purpose To evaluate short-term changes in optic nerve head topography and visual field induced by surgical reduction of intraocular pressure. Methods A prospective study was performed on 56 eyes of 56 patients with uncontrolled primary open-angle glaucoma despite maximum medical therapy, which underwent trabeculectomy. Optic nerve head evaluations by means of Heidelberg Retina Tomograph, and visual field tests were performed pre-operatively, and at 3 and 6 months after surgery. Differences in intraocular pressure, visual field indices, and Heidelberg Retina Tomograph parameters were evaluated with the t-test for paired data. A linear regression model was calculated to analyze the relationship between intraocular pressure reduction and visual field changes, and optic nerve head changes. Results Mean intraocular pressure decreased from 24.4 ± 5.0 mm Hg to 12.1 ± 3.1 mm Hg (month 3, Po0.001), and 10.6±2.8 mm Hg (month 6, Po0.001) after trabeculectomy. Mean retinal nerve fiber layer thickness (baseline, 0.19±0.034; month 3, 0.24 ± 0.039, P ¼ 0.05; month 6, 0.21 ± 0.037, P ¼ 0.05) showed a statistical significant change compared with baseline values. Conclusions In this 6-months study, a significant increase in retinal nerve fiber layer thickness was detected after glaucoma filtration surgery.

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“…Longterm fluctuation is significantly larger in individuals with abnormal fields, and has been shown to increase with increasing depth of visual field defects. It actually reaches a maximum at locations with moderate depression of threshold sensitivity (10-20 dB range of threshold) but is lower at locations with severe loss since the lower end of the dynamic range is reached at those locations [10][11][12][13]. This increased variability is considered to be mostly caused by the reduced number of ganglion cells since it decreases when a larger size V stimulus is used [14].…”

Section: Long-term Fluctuationmentioning

confidence: 99%

Detection of visual field progression in glaucoma with standard achromatic perimetry: A review and practical implications

Nouri‐Mahdavi

Nassiri

Giangiacomo

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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Detection of visual field progression remains a challenging task despite the recent advances for better handling of longitudinal visual field data, some of which are incorporated in currently available perimeters. Standard achromatic perimetry remains the gold standard for detection of visual field progression. The authors present a practical and clinically relevant review of the main issues involved in detection of early glaucoma as well as detection of visual field progression in eyes with pre-existing glaucomatous damage. After discussing some basic concepts in perimetry, the authors present evidence-based recommendations for criteria to detect earliest evidence of glaucomatous damage with perimetry. The authors will review different event- and trend-based criteria and present data with regard to comparative performance of such criteria. Relevance of using absolute versus corrected threshold data with regard to different criteria is also addressed. At the end, the authors provide practical guidelines for detection of visual field progression in a clinical setting and review issues related to clinical trials.

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Long-term perimetric fluctuation in patients with different stages of glaucoma

Cited by 31 publications

References 16 publications

Visual Field Progression in Glaucoma: Estimating the Overall Significance of Deterioration with Permutation Analyses of Pointwise Linear Regression (PoPLR)

Visual Field Progression in Glaucoma: Estimating the Overall Significance of Deterioration with Permutation Analyses of Pointwise Linear Regression (PoPLR)

Short-term changes in the optic nerve head and visual field after trabeculectomy

Detection of visual field progression in glaucoma with standard achromatic perimetry: A review and practical implications

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