The relationship of hypertriglyceridemia and left ventricular remodeling types in patients with chronic kidney disease

Муркамилов, И Т; Сабиров, И С; Фомин, В В; Айтбаев, К А; Муркамилова, Ж. А.

doi:10.26442/00403660.2019.06.000047

Cited by 6 publications

(18 citation statements)

References 19 publications

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“…В то же время магнитно-резонансная томография как гораздо более чувствительный метод (в последнее время с этой целью начато применение позитронно-эмиссионной томографии) нередко выявляет именно локальные признаки отека, в т.ч. отека миокарда предсердий у больных с иммунными формами миокардита [11].…”

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Myocardial morphological changes and pulmonary vein catheter ablation efficacy in patients with atrial fibrillation

Kalemberg¹,

Davtyan²,

Благова

et al. 2021

Russ J Cardiol

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Aim. To study the association between morphological changes and comorbidities and atrial fibrillation (AF) catheter ablation efficacy, and to evaluate morphological predictors of AF recurrence in patients with durable pulmonary vein isolation (PVI) after catheter intervention.Material and methods. Fifty-four patients with paroxysmal/persistent AF without severe structural heart disease were enrolled in this study who underwent primary pulmonary vein cryoballoon ablation (CBA) with simultaneous implantation of an electrocardiogram loop recorder (Medtronic Reveal XT) and interatrial/interventricular septum biopsy. The follow-up duration was 12 months with scheduled 3, 6 and 12 month visits. Patients with recurrent AF were referred for redo procedure, where the PVI durability was assessed. The follow-up duration after the second procedure was also 12 months. The patients were divided into two groups: patients without recurrent AF and patients with recurrent AF after two catheter interventions.Results. In interventricular septum biopsy samples we found the morphological criteria of myocarditis in 70% of the patients (n=34). Individual morphological changes were detected in all patients. The most common types were cardiomyocyte hypertrophy — 98,1% (n= 52), overcrossing of cardiomyocytes — 77,4% (n=41) and lymphohistiocytic infiltration of the interstitium by more than 14 cells — 75,5% (n=40). Patients with persistent AF were significantly more likely to have endothelial cell swelling (55% vs 45%, p=0,022). Interstitial tissue edema was the only morphological parameter significantly associated with AF recurrence (p=0,03).Conclusion. In patients with AF and no structural heart disease who underwent drug-resistant AF cryoballoon ablation, morphological changes in the myocardium of the atria and ventricles are detected in 100% of cases. The predominant biopsy diagnosis is myocarditis. Morphological signs of the inflammatory process activity, as interstitial tissue edema are associated with the high incidence of non-venous AF. Further preoperative evaluation is needed to identify patients with non-venous atrial fibrillation, which will increase the effectiveness of interventional approach.

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Section: Discussionunclassified

Myocardial morphological changes and pulmonary vein catheter ablation efficacy in patients with atrial fibrillation

Kalemberg¹,

Davtyan²,

Благова

et al. 2021

Russ J Cardiol

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“…Неспецифический аортоартериит (артериит Такаясу (АТ), болезнь Такаясу, болезнь отсутствия пульса) -аутоиммунное заболевание, характеризующееся деструктивно-продуктивным сегментарным аортитом и субаортальным панартериитом богатых эластическими волокнами артерий с возможным поражением коронарных и легочных ветвей [1][2][3].…”

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“…Имеются данные, что в России распространенность его достигает 2,6 человека на 1 млн населения [3]. Заболевание наиболее характерно для девушек с клиническим дебютом в возрасте 15-35 лет (по различным данным соотношение с мужчинами от 2:1 в западных странах до 10:1 в восточных) [1,2].…”

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“…Точная причина заболевания не установленаобсуждается роль вирусов, инфекции, в частности, микобактерии туберкулеза. Имеются сведения о генетической предрасположенности заболевания, за данную теорию говорит тот факт, что у трети пациентов с АТ был обнаружен аллель HLA-B52 [1,2].…”

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“…Поражение коронарного русла сердца и легочных артерий при АТ встречается примерно в равном количестве случаев, 5-20% и 7-18%, соответственно. Поражение правой коронарной артерии встречалось наиболее часто [1,2].…”

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Takayasu's arteritis in a patient with suspected acute coronary syndrome — a literature review and a case report

et al. 2021

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Takayasu's arteritis is a chronic granulomatous vasculitis of large vessels of unclear etiology, predominantly affecting the aorta and its main branches, with possible involvement of the coronary and pulmonary arteries. The true prevalence of this disease is unknown, but it is extremely low, given the rare diagnosis and the absence of pathognomonic symptoms. In clinical practice, the criteria proposed by the American College of Rheumatology are used for making a diagnosis. A wide range of imaging diagnostic techniques plays a significant role. This article provides a literature review and a case report of Takayasu's arteritis in a patient admitted with an acute coronary syndrome.

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Association of hypertriglyceridemia with risk factors for cardiovascular and renal complications in individuals with high cardiovascular risk

et al. 2023

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Aim. To study clinical and functional manifestations of hypertriglyceridemia and its association with risk factors for cardiovascular and renal complications in individuals with high cardiovascular risk.Material and methods. The study included 272 patients (129 men and 143 women; mean age, 53,9±13,7 years) with a high cardiovascular risk, which was stratified using Systematic Coronary Risk Evaluation (SCORE) model by the presence of cardiovascular disease, and/or diabetes, and/or age ≥65 years, and/or blood pressure (BP) >180/110 mm Hg, and/or total cholesterol (TC) level >8,0 mmol/l. All study participants underwent clinical and paraclinical examination. Serum content of triglycerides (TGs) ≥1,7 mmol/L was considered hypertriglyceridemia (HTG). Depending on TG level, the entire sample was divided into 2 following subgroups: subgroup 1 (n=178) — serum triglycerides ≤1,6 mmol/l; subgroup 2 (n=94) — serum triglycerides ≥1,7 mmol/l, i.e. HTG.Results. We revealed significantly more persons with obesity (46,8%) and type 2 diabetes (28,7%) in HTG subgroup. There were 56,3% and 36,1% patients of HTG subgroup with hypertension (HTN) and coronary artery disease (CAD), respectively. A mid-high TG level (from 1,7 to 2,3 mmol/l) in the subgroup of patients with HTG was detected in 38,3% of cases. The serum content of TG from 2,3 to 5,6 mmol/l was detected in 54,2% of patients. TG level ≥5,6 mmol/l was detected in 7,5% of cases. In the subgroup of patients with HTG, high levels of systolic, diastolic and central (aortic) BP, body mass index, phosphorus, creatinine, cystatin C, estimated glomerular filtration rate (eGFR), and carotid intima-media thickness (IMT) were detected significantly more common. In the general sample, a significant direct relationship between TG concentration and cystatin C (r=0,168) and an inverse (negative) relationship with eGFR (r=-0,220) was obtained.Conclusion. Elevated serum TG levels are often observed in individuals with obesity, type 2 diabetes, hypertension and CAD. Patients with HTG had a pronounced cardiovascular and renal risk, including a significant increase in BP and carotid IMT, high levels of total cholesterol, low-density lipoprotein cholesterol, phosphorus, creatinine, cystatin C, and a decrease in eGFR. HTG was associated with an increase in serum cystatin C and a deterioration in renal nitrogen excretion.

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The relationship of hypertriglyceridemia and left ventricular remodeling types in patients with chronic kidney disease

Cited by 6 publications

References 19 publications

Myocardial morphological changes and pulmonary vein catheter ablation efficacy in patients with atrial fibrillation

Myocardial morphological changes and pulmonary vein catheter ablation efficacy in patients with atrial fibrillation

Takayasu's arteritis in a patient with suspected acute coronary syndrome — a literature review and a case report

Association of hypertriglyceridemia with risk factors for cardiovascular and renal complications in individuals with high cardiovascular risk

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