The relationship of hip fracture and thyroid disorders: a systematic review

SeyedAlinaghi, SeyedAhmad; Yarmohammadi, Soudabeh; Dashti, Mohsen; Ghasemzadeh, Afsaneh; Siami, Haleh; Molla, Ayoob; Mahrokhi, Sona; Qaderi, Kowsar; Arjmand, Ghazal; Parikhani, Sahar Nooralioghli; Amrollah, Masoomeh Fathi; Mirghaderi, Peyman; Mehraeen, Esmaeil; Dadras, Omid

doi:10.3389/fendo.2023.1230932

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…Thyroid hormones play an important role in bone metabolism, including bone formation and resorption processes 11 , 14 . Additionally, close associations between thyroid hormones and bone density, osteoporosis, and osteoporotic fractures have been consistently observed in clinical practice 49 , 50 .…”

Section: Discussionmentioning

confidence: 83%

Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis

Qi,

Wang,

Hong

et al. 2024

Sci Rep

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The prevalence of thyroid dysfunction diseases (TDFDs) and osteoporosis (OP) is high. Previous studies have indicated a potential association between TDFDs and OP, yet the causal direction remains unclear. This study aimed to investigate the potential causal relationship between TDFDs and the risk of developing OP and related fractures. We obtained pooled data from genome-wide association studies (GWASs) conducted on TDFDs and OP in European populations and identified single-nucleotide polymorphisms (SNPs) with genome-wide significance levels associated with exposure to TDFDs as instrumental variables. Inverse variance weighted (IVW) was employed as the primary method for Mendelian randomization (MR) analysis, supplemented by MR‒Egger, weighted median, simple mode and weighted mode methods. Sensitivity analyses were conducted to evaluate the robustness of the findings. The IVW method demonstrated an increased risk of OP in patients with TDFDs, including hyperthyroidism and hypothyroidism (TDFDs: OR = 1.11; 95% CI 1.09, 1.13; hypothyroidism: OR = 1.14; 95% CI 1.10, 1.17; hyperthyroidism: OR = 1.09; 95% CI 1.06, 1.12). These findings were supported by supplementary analysis, which revealed a positive correlation between TDFDs and the risk of OP. Multiple sensitivity analyses confirmed the absence of horizontal pleiotropy in the study, thus indicating the robustness of our results. The causal relationship between TDFDs and increased risk of OP implies the need for early bone mineral density (BMD) screening and proactive prevention and treatment strategies for individuals with TDFDs.

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Section: Discussionmentioning

confidence: 83%

Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis

Qi,

Wang,

Hong

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Thyroid hormones play an important role in bone metabolism including bone formation and resorption processes [11,14]. Additionally, the close association between thyroid hormones and bone density, osteoporosis, as well as osteoporotic fractures has been consistently observed in clinical practice [34,35].…”

Section: Discussionmentioning

confidence: 98%

Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis

Qi,

Wang,

Yao

et al. 2024

Preprint

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Background Thyroid dysfunction diseases (TDFDs) and osteoporosis (OP) have a high prevalence in the population. Previous studies have indicated a potential association between TDFDs and OP, yet the causal direction remains unclear. This study aims to investigate the potential causal relationship between TDFDs and the risk of developing OP and related fracture. Methods We obtained pooled data from genome-wide association studies (GWAS) conducted on TDFDs and OP in European populations, and identified single nucleotide polymorphisms (SNPs) with genome-wide significance levels associated with exposure to TDFDs as instrumental variables. Inverse variance weighting (IVW) was employed as the primary method for MR analysis, supplemented by MR-Egger, Weighted median, Simple mode and Weighted mode methods. Sensitivity analyses were conducted to evaluate the robustness of the findings. Results The IVW method demonstrated an increased risk of osteoporosis (OP) in patients with TDFDs, including hyperthyroidism and hypothyroidism (TDFDs: OR = 1.11; 95% CI 1.09, 1.13; hypothyroidism: OR = 1.14; 95% CI 1.10, 1.17; hyperthyroidism: OR = 1.09; 95% CI 1.06, 1.12). These findings were further supported by the supplementary analysis, which revealed a positive correlation between TDFDs and the risk of OP. Multiple sensitivity analyses confirmed the absence of horizontal pleiotropy and heterogeneity in the study, thus indicating the robustness of our results. Conclusion The observed causal association between TDFDs and OP, indicating an increased risk of OP in patients with TDFDs, implies the necessity of early BMD screening and implementation of proactive prevention and treatment strategies for individuals with TDFDs.

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Physical exercise as part of the rehabilitation in primary osteoporosis: insights into the signal transduction bone formation pathways

Stanciu,

Nistor,

Iliescu

et al. 2024

Balneo and PRM Research Journal

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Primary osteoporosis, a geriatric bone metabolic condition affecting both the mineral density and the microarchitecture, comes with a complex burden. Bone turnover markers tidily reflect the changes of skeleton status that are part of the physiological process or theyhighlight the abnormal status including in osteoporosis in addition to other biomolecules evaluation such as hormones, inflammatory markers, myokines and adipokines. In this narrative review, we aimed to highlight several aspects regarding osteoporosis-related rehabilitation amid mitigating the role of physical exercise as bone formation booster. Bone turnover markers assays, by capturing the essence of the bone remodelling, registered a great progress during latest years, thus show-ing an enhanced index of applicability in daily practice (despite being known and studied for more than three decades). Irisin, a novel player in the muscle-bone-metabolism cross-talk, represents a muscle-derivate hormone that is expected to highlight the interplay between physical exercise and bone formation. Other concurrent signal transduction pathways include recently described biomarkers such as preptin or the spectrum associated with serotonin-LRP5-Wnt/beta catenin canonical and non-canonical loops. Current pitfalls of the topic include the personalized recommendation of physical activity due to severe co-morbidities, the lack of homogenous studies to measure the intervention and the consecutive bone health and great variations of using the bone turnover markers amid daily practice in different centers. To conclude, part of the monitoring protocol in osteoporotic patients under specific medication against osteoporosis or during bisphosphonates drug holiday, bone turnover markers assays stands for a practical insight in every day practice. The contributing role of physical exercise to boost bone formation as reflected by these biomolecules is well understood across a multitude of signal transduction pathways. However, a current gap in practical use and surveillance of the prescription of physical activity, mechanical load and rehabilitation programs in these patients is confirmed so far. Keywords: osteoporosis, bone, fracture, rehabilitation, physical exercise, bone turnover markers, osteocalcin.

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The relationship of hip fracture and thyroid disorders: a systematic review

Cited by 3 publications

References 47 publications

Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis

Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis

Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis

Physical exercise as part of the rehabilitation in primary osteoporosis: insights into the signal transduction bone formation pathways

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