Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis
Weihui Qi,
Dong Wang,
Jun Yao
et al.
Abstract:Background
Thyroid dysfunction diseases (TDFDs) and osteoporosis (OP) have a high prevalence in the population. Previous studies have indicated a potential association between TDFDs and OP, yet the causal direction remains unclear. This study aims to investigate the potential causal relationship between TDFDs and the risk of developing OP and related fracture.
Methods
We obtained pooled data from genome-wide association studies (GWAS) conducted on TDFDs and OP in European populations, and identified single n… Show more
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