The relationship of health-related quality of life and treatment outcome during inpatient treatment of depression

Köhler, Stephan; Unger, Theresa; Hoffmann, Sabine; Mackert, A.; Ross, Barbara; Fydrich, Thomas

doi:10.1007/s11136-014-0811-8

Cited by 18 publications

(14 citation statements)

References 37 publications

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“…This means that depressive symptoms had a greater extent of change than HRQOL after the 6-week treatment [ 7 ]. This finding was also in accordance with other studies [ 43 – 45 ]. Furthermore, this finding was highly in line with theoretical models of response in mental health, especially the “phase model” proposed by Howard et al [ 46 ], which posits that first a general hope factor causes a response similar to a placebo effect, then specific symptoms change and anything connected to the interpersonal and real life setting of the patients responds quite a bit later.…”

Section: Discussionsupporting

confidence: 94%

Factors related to the improvement in quality of life for depressed inpatients treated with fluoxetine

et al. 2017

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BackgroundThe aim of this study was to explore the relationships between depressive symptoms and health-related quality of life (HRQOL) measurements for inpatients with major depressive disorder (MDD) before and after 6-week fluoxetine treatment, and to elucidate the factors related to the HRQOL changes.MethodsA total of 131 inpatients with MDD were enrolled to receive 20 mg of fluoxetine for 6 weeks. Symptom severity and adverse events were assessed at weeks 0, 1, 2, 3, 4, and 6 using the 17-item Hamilton Depression Rating Scale (HAMD-17) and UKU Side Effect Rating Scale, respectively. HRQOL was measured using the Short Form 36 (SF-36), including 8 subscales, physical component summary (PCS) and mental component summary (MCS), at baseline and week 6. Spearman’s coefficient, Cohen’s d, and multiple linear regression model were used for statistical analysis.ResultsOne hundred and six patients completing all measures at weeks 0 and 6 entered the analysis. HAMD-17 negatively correlated with SF-36 at baseline and week 6. The HAMD-17 had a larger effect size than SF-36. MCS, rather than PCS, showed statistically significant improvement. After using multiple linear regression analysis, age at onset, HAMD-17 score change, and number of adverse events reported during the trial period were related to MCS change after adjusting for confounding variables.ConclusionsFluoxetine treatment was associated with an improvement in depressive symptomology and HRQOL. Depressive symptoms had a greater extent of change than HRQOL. Clinicians must consider the negative effects of adverse events caused by antidepressants on the improvement of HRQOL.Trial registration http://clinicaltrials.gov, NCT01075529, retrospectively registered 24/2/2010.

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Section: Discussionsupporting

confidence: 94%

Factors related to the improvement in quality of life for depressed inpatients treated with fluoxetine

et al. 2017

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“…In psychiatric conditions, HRQoL is associated with child psychopathology across disorders [8] and has been utilized as an outcome measure for major depressive disorder [9] and panic disorder [10]. For example, better HRQoL after treatment for depression was associated with reduced remission rates and fewer somatic symptoms [9]. Similarly, improvements in HRQoL are associated with reduced anxiety-related avoidance, as well as remission of anxiety-related disorders [10].…”

Section: Introductionmentioning

confidence: 99%

Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome

et al. 2020

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Health-related quality of life (HRQoL) is a multidimensional concept involving physical, psychological, social, and cognitive aspects of life. Individuals with Fragile X syndrome (FXS) experience a life-long disorder that impacts the HRQoL of the affected individual and their family. Thus, HRQoL may be an important outcome measure following intervention. However, it is yet not known whether HRQoL concerns relate to observed impairments in FXS. In the present study, we examined the nature and degree of association between HRQoL and established measures of functioning in FXS using the Parent Report for Children version of the PedsQL 4.0 Generic Core Scales and Cognitive Functioning Scale. We observed significant relationships between HRQoL a nd measures of adaptive behavior, maladaptive behaviors, and social functioning. The present study has implications for treatment outcomes for clinical trials in FXS.

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“…These findings have lead researchers to examine possible antidepressant effects of exercise, the assumption being that exercise could have multiple beneficial effects on mental as well as physical health. Recent research concerning healthrelated quality of life has stressed the importance of treating depressive symptoms as well as somatic comorbidities, as their combined impact on quality of life seems to be especially disabling (Köhler et al 2014). A recent meta-analysis of exercise in depression concluded that exercise may have a moderate effect on depression (Cooney et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Self-selected intensity exercise in the treatment of major depression: A pragmatic RCT

Doose

Ziegenbein²,

Hoos

et al. 2015

International Journal of Psychiatry in Clinical Practice

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The relationship of health-related quality of life and treatment outcome during inpatient treatment of depression

Cited by 18 publications

References 37 publications

Factors related to the improvement in quality of life for depressed inpatients treated with fluoxetine

Factors related to the improvement in quality of life for depressed inpatients treated with fluoxetine

Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome

Self-selected intensity exercise in the treatment of major depression: A pragmatic RCT

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