Self-selected intensity exercise in the treatment of major depression: A pragmatic RCT

Doose, Michael; Ziegenbein, Marc; Hoos, Olaf; Reim, Dominik; Stengert, Wojciech; Hoffer, Niklas; Vogel, Charlotte; Ziert, Yvonne; Sieberer, Marcel

doi:10.3109/13651501.2015.1082599

Cited by 23 publications

(34 citation statements)

References 38 publications

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“…Several other clinical studies have demonstrated that exercise is highly effective at reducing the clinical symptoms and minimizing the rate of reoccurrence of MDD episodes(Blumenthal et al, 2007;Doose et al, 2015;Dunn et al, 2005). The general consensus among experts remains that more frequent activity over a longer period of time, results in greater efficacy of exercise in the treatment ofMDD (Carek et al, 2011), which is likely due, at least in part, to the inflammation-altering effects of exercise.…”

mentioning

confidence: 95%

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Spielman

Little

Klegeris

2016

Brain Research Bulletin

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confidence: 95%

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Spielman

Little

Klegeris

2016

Brain Research Bulletin

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“…The important study of Doose et al [36] did not clarify three aspects of the impact of preferred intensity exercise on depression, which are in the scope of the current study. First, Doose et al did not employ the benchmark prescribed-intensity exercise as a direct comparator.…”

Section: Introductionmentioning

confidence: 79%

“…The pragmatic RCT by Doose et al [36] explored the clinical and individual antidepressant effects of an eightweek ideographic preferred intensity exercise model (n = 30) vs. the wait-for-intervention condition (n = 16) in patients diagnosed with a depressive episode. Pre-and post-intervention depression assessed via a self-report outcome [Beck Depression Inventory-II [BDI-II]; 37] showed 36.67, 16.67 and 46.67% of the preferred intensity group with scores consistent with depression recovery, improvement and non-significant change, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Pre-and post-intervention depression assessed via a self-report outcome [Beck Depression Inventory-II [BDI-II]; 37] showed 36.67, 16.67 and 46.67% of the preferred intensity group with scores consistent with depression recovery, improvement and non-significant change, respectively. When Doose et al [36] rated pre-and post-intervention depression via a clinician-report outcome (Hamilton Rating Scale for Depression-17 ; [37]), the preferred intensity patients with recovery coefficients increased to 63.33%, and with improvement and non-significant change dropping to 13.33 and 23.33%, respectively.…”

Section: Introductionmentioning

confidence: 99%

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A pragmatic randomised controlled trial of preferred intensity exercise in depressed adult women in the United Kingdom: secondary analysis of individual variability of depression

et al. 2019

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Background: This study is a secondary analysis of the trial by Callaghan et al. (2011), which reported higher antidepressant effects for preferred intensity (n = 19) vs. prescribed intensity (n = 19) exercise of three sessions/week over four weeks in depressed women. In particular, the present study sought to examine whether greater clinically significant individual change/recovery was observed in the preferred compared to the prescribed exercise group. Methods: The reliable change index and the C cutoff score criteria described by Jacobson and Truax (1991) were employed to determine clinical significance. These criteria examined if individual change in depression scores from pre-to post-intervention in the preferred intensity group were statistically significant beyond the standard error of difference derived from the active comparator prescribed group, and subsequently within a normal population range. Patients fulfilling the first or both criteria were classified as improved or recovered, respectively. Results: Post-intervention depression scores of six patients in the preferred intensity exercise group (32%) demonstrated statistically reliable improvement (p < 0.05) and recovery. Half of this subgroup started as moderately depressed. No patient demonstrated a reliable deterioration in depression. Due to a small sample size, it was impossible to determine whether patients on psychiatric medication or medication-free patients were equally benefited from preferred intensity exercise. Thirteen patients in the preferred intensity group (68%) displayed nonstatistically significant change in post-intervention depression scores (p > 0.05), although eight of them showed a non-significant improvement in post-intervention depression scores and three could not technically show an improvement in depression due to floor effects (baseline depression within normal range). Conclusions: Preferred intensity exercise of three sessions/week over four weeks led almost a third of the patients to record scores consistent with recovery from depression. Health professionals may consider that short-term preferred intensity exercise provides clinically significant antidepressant effects comparing favourably to exercise on prescription.

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“…The beneficial effect of PA on depression has been previously studied. Small intervention studies assessing the amelioration of pre-existent depression suggested that physical activity could be beneficial when treating adults with depression, [18] and the Cochrane Collaboration in a 2013 review, concluded that physical activity had clinical effects on depressive patients [19].…”

Section: Introductionmentioning

confidence: 99%

Dimensions of leisure-time physical activity and risk of depression in the “SEGUIMIENTO UNIVERSIDAD DE NAVARRA” (SUN) prospective cohort

Fernandez‐Montero

Moreno‐Galarraga

Sánchez‐Villegas

et al. 2020

Preprint

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Background: An inverse association between total leisure-time physical activity (LTPA) and depression has been previously documented in the scientific literature. Our objective was to prospectively assess the association of LTPA with the risk of depression, focusing on several dimensions of LTPA (intensity, duration and type). Methods: The SUN (Seguimiento Universidad de Navarra) project is a prospective cohort study formed by Spanish university graduates. A total of 15,488 adults (40.2% men, mean age 37±12 years) initially free of depression were assessed. A report of a validated medical diagnosis of depression or the habitual use of antidepressants (any of both) were considered as incident cases of depression. LTPA was estimated through previously validated self-reported questionnaires. Participants were classified following Physical Activity recommendations from the World Health Organization, and according to the intensity, duration and type of LTPA. Cox proportional hazards regression models were run, adjusted for demographic, lifestyle, and dietary factors, to estimate adjusted hazard ratios (HR) of depression and 95% confidence intervals (CI). Results: During 163,059 person-years of follow-up we registered 870 incident cases of depression. Participants with higher total LTPA (METs-h/wk) and higher duration of LTPA (hours/wk) exhibited a lower risk of depression HR=0.84 (95% CI: 0.72-0.99) and HR=0.83 (0.70-0.99) respectively, whereas intensity of LTPA (MET) did not show any association with depression. Conclusion: Participants with higher LTPA had a lower risk of depression. The inverse association was stronger for total LPTA time than for its intensity. Higher duration of LTPA should be encouraged to prevent depression.

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Self-selected intensity exercise in the treatment of major depression: A pragmatic RCT

Abstract: We observed a large and clinically significant change in HRSD-17 scores. Moderate changes in BDI-II scores without clinical significance and small changes in physical fitness assessments were observed.

Cited by 23 publications

References 38 publications

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Physical activity and exercise attenuate neuroinflammation in neurological diseases

A pragmatic randomised controlled trial of preferred intensity exercise in depressed adult women in the United Kingdom: secondary analysis of individual variability of depression

Dimensions of leisure-time physical activity and risk of depression in the “SEGUIMIENTO UNIVERSIDAD DE NAVARRA” (SUN) prospective cohort

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