The relationship of fat soluble antioxidants with gestational diabetes in Iran: a case–control study

Hekmat, Khadijeh; Bagheri, Roghieh; Abedi, Parvin; Tabesh, Hamed

doi:10.3109/14767058.2014.892921

Cited by 13 publications

(14 citation statements)

References 19 publications

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“…The altered antioxidant system is also observed and persists with age in the macrosomic rat and human newborns that became obese adults [ 27 , 46 ]. These observations are recently supported by several investigators who have observed increased oxidative stress in gestational diabetic women and animals [ 55 – 58 ] and their infants [ 59 ] and rat adult offspring [ 60 ]. In fact, our findings suggest that there is an increased oxidative stress in diabetic pregnant women and rats and their adult obese offspring that were macrosomic as newborns [ 27 , 46 ], in agreement with the results of previous studies [ 61 – 64 ].…”

Section: Major Metabolic Complications During Gestational Diabetessupporting

confidence: 57%

Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity

Yessoufou

Nekoua

Gbankoto

et al. 2015

Journal of Diabetes Research

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Omega-3 polyunsaturated fatty acids (PUFAs) are increasingly being used to prevent cardiovascular diseases, including diabetes and obesity. In this paper, we report data on the observed effects of omega-3 PUFA on major metabolic disorders and immune system disruption during gestational diabetes and their consequences on macrosomia. While controversies still exist about omega-3 PUFA effects on antioxidant status regarding the level of omega-3 PUFA in diet supplementation, their lipid-lowering effects are unanimously recognized by researchers. Animal studies have shown that omega-3 PUFA contributes to the maintenance of the immune defense system by promoting the differentiation of T helper (Th) cell to a Th2 phenotype in diabetic pregnancy and by shifting the Th1/Th2 ratio from a deleterious proinflammatory Th1 phenotype to a protective anti-inflammatory Th2 phenotype in macrosomia and in adulthood obesity that results from macrosomia at birth. Based on the available evidence, international nutritional and food agencies recommend administration of omega-3 PUFA as triglyceride-lowering agents, for the prevention of cardiovascular disease risk and during human pregnancy and lactation. Furthermore, studies targeting humans are still required to explore application of the fatty acids as supplement in the management of gestational diabetes and inflammatory and immune diseases.

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Section: Major Metabolic Complications During Gestational Diabetessupporting

confidence: 57%

Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity

Yessoufou

Nekoua

Gbankoto

et al. 2015

Journal of Diabetes Research

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“…Among diabetic pregnancies, the adipokine RBP does not have a statistically significant association with the occurrence of PE ( 92 ). Other studies have investigated the association between higher RBP concentrations and the risk of gestational diabetes, finding both positive ( 93–96 ) and negative associations ( 97 ).…”

Section: Resultsmentioning

confidence: 99%

Vitamin A Requirements in Pregnancy and Lactation

Gannon

Jones

Mehta

2020

Current Developments in Nutrition

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Pregnancy and lactation are critical life stages with unique nutritional requirements, including for vitamin A (VA). Current Dietary Reference Intakes (DRIs) for VA were published in 2001. The objective of this review was to identify and categorize evidence related to VA requirements in pregnancy and lactation since these DRIs were formulated. We searched MEDLINE and included articles according to an analytic framework of maternal VA exposure on status and health outcomes in the mother-child dyad. Intermediate and indirect evidence supports that maternal VA intakes can impact the mother's VA status, breastmilk, and health outcomes, as well as the child's VA status and select health outcomes. Food-based approaches may lead to more sustained, sufficient VA status in mothers and children. Research needs include further study linking maternal VA intakes on maternal and child VA status, and further associations with outcomes to determine intake requirements to optimize health.

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“…In the present study, we found a negative association between GDM and serum levels of vitamin A at 24 weeks of gestation. Previous studies reported that GDM pregnant women may have lower vitamin A and E levels and suggest that this could be due to the increased oxidative status found under this condition as compared to healthy pregnancies [16–19]. However, maternal supplementation with vitamin C/E in type 1 diabetes failed to increase cord or placental levels of these vitamins and it had no effect on placental markers of oxidative stress, activity of antioxidant enzymes, or lipid peroxidation markers [44].…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis showed that maternal serum vitamin E level is significantly lower in pregnant women with gestational diabetes mellitus (GDM) as compared to healthy ones [16]. GDM has also been associated with low vitamin A status during pregnancy [17][18][19]. Supplementation with omega-3 fatty acids in combination with vitamin D or E can alleviate maternal oxidative stress in women with GDM or prediabetes [20] while there is no information on its effect on cord antioxidant status.…”

Section: Introductionmentioning

confidence: 99%

Serum Vitamins A and E at Mid-Pregnancy and Their Relationships with Both Maternal and Cord Blood Antioxidant Status and Perinatal Conditions: The NELA Cohort

Sánchez-Campillo,

Gázquez,

Serrano-Munuera

et al. 2023

Ann Nutr Metab

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Introduction: Most of the pregnant women do not achieve the recommended dietary intake of vitamins A and E. These vitamins may counteract oxidative stress involved in some adverse perinatal outcomes. We aimed to assess the associations between maternal vitamin A and E at mid-pregnancy with both maternal and fetal outcomes and to identify possible early biomarkers during pregnancy to predict and prevent oxidative stress in the offspring. Methods: Data on dietary and serum levels of vitamins A and E were collected from 544 pregnant women from the Nutrition in Early Life and Asthma (NELA) study, a prospective mother-child cohort set up in Spain. Results: There were large discrepancies between low dietary vitamin E intake (78% of the mothers) and low serum vitamin E levels (3%) at 24 weeks of gestation. Maternal serum vitamins A and E at mid-pregnancy were associated with higher antioxidant status not only in the mother at this time point (lower hydroperoxides and higher total antioxidant activity [TAA]) but also with the newborn at birth (higher TAA). Gestational diabetes mellitus (GDM) was negatively associated with maternal serum vitamin A (OR: 0.95 CI: 0.91–0.99, p = 0.009) at mid-pregnancy. Nevertheless, we could not detect any association between GDM and oxidative stress parameters. Conclusions: In conclusion, maternal vitamin A and E serum levels may be used as an early potential biomarker of antioxidant status of the neonate at birth. Control of these vitamins during pregnancy could help avoid morbid conditions in the newborn caused by oxidative stress in GDM pregnancies.

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The relationship of fat soluble antioxidants with gestational diabetes in Iran: a case–control study

Abstract: The level of retinol in the diabetic pregnant women was significantly lower than that in the control group. This reduction may be due to the reduced antioxidant defences in women with GDM.

Cited by 13 publications

References 19 publications

Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity

Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity

Vitamin A Requirements in Pregnancy and Lactation

Serum Vitamins A and E at Mid-Pregnancy and Their Relationships with Both Maternal and Cord Blood Antioxidant Status and Perinatal Conditions: The NELA Cohort

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