The Relationship of Aflatoxin B1 and Hepatocellular Carcinoma: A Mini Review

Valdes, Salvador Lopez

doi:10.15406/jlrdt.2017.03.00073

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Once AFB1 is ingested, it is metabolized by the cytochrome P-450 system into the intermediate reactive oxygen species (ROS): afatoxin-8, 9-expoxide, which can interfere with DNA forming. AFB1-guanine products can react with proteins forming AFB1-albumin which ultimately leads to acute toxicity (aflatoxicosis) and lesions, respectively [86]. Failing to repair these lesions triggers DNA mutations in key genes; particularly "G to T" transversions.…”

Section: Aflatoxin B1 (Afb1)mentioning

confidence: 99%

Risk Factors Associated With Development of Hepatocellular Carcinoma in Hepatitis C Virus Patients

El‐Shenawy¹,

Farouk²,

Helmy³

et al. 2023

Hepatitis C - Recent Advances

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Hepatitis C virus (HCV) is the main etiology of advanced liver fibrosis and cirrhosis with significant risk to progression to HCC .In most cases, HCC occurs in individuals with chronic liver diseases, such as cirrhosis caused by hepatitis B or hepatitis C infection. Several parameters, genetic, viral and environmental play important role in the regulation of the host immune response to viral infection and its progression. Factors that increase the risk to HCC development include obesity, diabetes mellitus, nonalcoholic fatty liver disease, aflatoxin exposure, alcohol consumption and occult hepatitis c infection and genetic variations such as single nucleotide polymorphisms. Using the newly discovered direct acting antivirals (DAAs), great improvement in sustained virological immune response (SVR) has occurred >90% in treated patients irrespective to their fibrosis level. Nevertheless the progression to HCC in HCV patients who achieve (SVR) stay vulnerable for HCC development, especially patients with advanced fibrosis and/or cirrhosis

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Section: Aflatoxin B1 (Afb1)mentioning

confidence: 99%

Risk Factors Associated With Development of Hepatocellular Carcinoma in Hepatitis C Virus Patients

El‐Shenawy¹,

Farouk²,

Helmy³

et al. 2023

Hepatitis C - Recent Advances

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“…AF parent molecules (like AFB1) are relatively harmless, but the electrophilic intermediates AFBO (B1-8,9-epoxide) that are generated at the predominant AF metabolization site are mutagenic and carcinogenic [111,112]. The major human cytochrome p450 enzymes are responsible for converting AFB1 into two reactive 8,9-epoxide stereoisomers (exo and endo) [108].…”

Section: Health Impacts Of Afs In Chinamentioning

confidence: 99%

Distribution of Aspergillus Fungi and Recent Aflatoxin Reports, Health Risks, and Advances in Developments of Biological Mitigation Strategies in China

Mamo

Abate²,

Zheng

et al. 2021

Toxins

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Aflatoxins (AFs) are secondary metabolites that represent serious threats to human and animal health. They are mainly produced by strains of the saprophytic fungus Aspergillus flavus, which are abundantly distributed across agricultural commodities. AF contamination is receiving increasing attention by researchers, food producers, and policy makers in China, and several interesting review papers have been published, that mainly focused on occurrences of AFs in agricultural commodities in China. The goal of this review is to provide a wider scale and up-to-date overview of AF occurrences in different agricultural products and of the distribution of A. flavus across different food and feed categories and in Chinese traditional herbal medicines in China, for the period 2000–2020. We also highlight the health impacts of chronic dietary AF exposure, the recent advances in biological AF mitigation strategies in China, and recent Chinese AF standards.

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Role of antioxidant supplementation in oxidant/antioxidant status and hepatotoxic effects due to aflatoxin B1 in wheat miller workers

Saad-Hussein

Moubarz

Mohgah

et al. 2019

Journal of Complementary and Integrative Medicine

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Background Aflatoxin B1 (AFB1) is classified as a Group I carcinogen. A Previous study found that oxidative stress from the metabolism of AFB1 induced hepatotoxic effects in wheat miller workers. Zinc and vitamin C may play a significant role in the activation of detoxification and overcoming the oxidative stress of AFB1. Objectives A prospective clinical trial was designed to evaluate the role of zinc and vitamin C oral supplementation on the oxidant-antioxidant status and the hepatotoxic effects of AFB1 in wheat miller workers. Methods Liver enzymes (ALT, AST, ALP, and GGT), P53 protein, malondialdehyde (MDA), glutathione S transferase (GST), Superoxide dismutase (SOD), zinc and vitamin C were estimated in 35 wheat miller workers before and after zinc and vitamin C supplementation for 1 month. Results The results revealed that zinc and vitamin C were significantly increased after the one-month supplementation, while liver enzymes (AST, ALP, and GGT), MDA, and GST of the workers were significantly decreased. SOD and P53 were also decreased but not to a significant level; SOD was decreased in 56% and P53 was decreased in 58% of the total workers. Conclusions Zinc and vitamin C oral supplementation for 1 month had an ameliorative effect on the hepatotoxicity of AFB1 in wheat miller workers, through decreasing MDA, SOD, and GST levels that in turn led to an improvement in their liver enzymes. Further study on a larger scale is needed to confirm these results.

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The Relationship of Aflatoxin B1 and Hepatocellular Carcinoma: A Mini Review

Cited by 3 publications

References 15 publications

Risk Factors Associated With Development of Hepatocellular Carcinoma in Hepatitis C Virus Patients

Risk Factors Associated With Development of Hepatocellular Carcinoma in Hepatitis C Virus Patients

Distribution of Aspergillus Fungi and Recent Aflatoxin Reports, Health Risks, and Advances in Developments of Biological Mitigation Strategies in China

Role of antioxidant supplementation in oxidant/antioxidant status and hepatotoxic effects due to aflatoxin B1 in wheat miller workers

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