Role of antioxidant supplementation in oxidant/antioxidant status and hepatotoxic effects due to aflatoxin B1 in wheat miller workers

Saad-Hussein, Amal; Moubarz, Gehan; Mohgah, Sh Abdalla; Shousha, Wafaa Gh.; Aya, H Mohamed

doi:10.1515/jcim-2018-0218

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…Animals exposed to AFB1 have a decrease in the amount of antioxidant enzymes and an increase in markers of oxidative stress [ 17 , 20 ]. Thus, treatment with antioxidant agents may provide protection against oxidative stress and, consequently, reduce the carcinogenic potential of these substances [ 37 , 38 ]. Finally, the importance of epigenetic lesions, mainly DNA methylation and modifications in histones, cannot be discarded in genotoxicity and mutagenicity processes [ 39 ].…”

Section: Effects Of Prenatal Exposure To Aflatoxin B1 In Animalsmentioning

confidence: 99%

Effects of Prenatal Exposure to Aflatoxin B1: A Review

2021

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Aflatoxins are mycotoxins produced as secondary fungal metabolites. Among them, aflatoxin B1 (AFB1) stands out due to its genotoxic and mutagenic potential, being a potent initiator of carcinogenesis. In this review, the outcomes from the published literature in the past 10 years on the effects of AFB1 pathophysiological mechanisms on embryological and fetal development are discussed. In several animal species, including humans, AFB1 has a teratogenic effect, resulting in bone malformations, visceral anomalies, lesions in several organs, and behavioral and reproductive changes, in addition to low birth weight. The mutagenic capacity of AFB1 in prenatal life is greater than in adults, indicating that when exposure occurs in the womb, the risk of the development of neoplasms is higher. Studies conducted in humans indicate that the exposure to this mycotoxin during pregnancy is associated with low birth weight, decreased head circumference, and DNA hypermethylation. However, as the actual impacts on humans are still unclear, the importance of this issue cannot be overemphasized and studies on the matter are essential.

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Section: Effects Of Prenatal Exposure To Aflatoxin B1 In Animalsmentioning

confidence: 99%

Effects of Prenatal Exposure to Aflatoxin B1: A Review

2021

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“…This can result in oxidative stress owing to an imbalance between limited antioxidant defenses and the excessive formation of ROS, resulting in the damage of biological molecules including lipids, proteins, and DNA in cellular systems [34,35]. In support of this hypothesis, several studies have demonstrated the potential for antioxidants to lower the risk of hepatotoxicity caused by exposure to the AF [29,[36][37][38][39]. Moreover, many studies have reported the pivotal role of oxidative stress induced by AF in eliciting programmed cell death or apoptosis through mitochondrial signaling pathways [25,[40][41][42].…”

Section: Discussionmentioning

confidence: 97%

“…A likely explanation of this association is not yet identified, though consumption of AF-contaminated foods and feeds were reported to cause diverse degrees of liver injury comprising development of fatty cysts, fibrosis, and cirrhosis among humans and animals [23][24][25][26][27]. However, several lines of evidence support oxidative stress as a key factor in AF induced initiation and progression of liver cirrhosis [28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…The toxic effects of AFB1 against the liver and other organs are closely related to its metabolic activation into the free radical AFB1-exo-8,9-epoxide (AFBO) by cytochrome P450 (CYP450) enzymes [32] and associated formation of reactive oxygen species (ROS) including hydroxyl radical (HO . ), per hydroxyl radical (HOO − ) and superoxide anion [29,33]. This can result in oxidative stress owing to an imbalance between limited antioxidant defenses and the excessive formation of ROS, resulting in the damage of biological molecules including lipids, proteins, and DNA in cellular systems [34,35].…”

Section: Discussionmentioning

confidence: 99%

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Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis

Mekuria

Routledge

Gong

et al. 2020

BMC Pharmacol Toxicol

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Background: Liver cirrhosis is characterized by fibrosis and nodule formation in the liver, due to a chronic injury, and subsequent alteration of the normal architecture of the liver. Even though there is a huge effort to elucidate the possible etiologic factors of liver cirrhosis, a significant number of cases are cryptogenic, especially in Sub Saharan Africa, where there is a high burden of aflatoxin exposure. Aflatoxins are known to cause hepatocellular carcinoma, which share similar etiologic factors with liver cirrhosis. This study aimed to assess the association between aflatoxin exposure and the risk of liver cirrhosis. Methods: Relevant studies were identified through systematic searches conducted in Ovid MEDLINE, PubMed and Google Scholar. Also, by searching the references of retrieved articles. The abstracts and full text were screened for eligibility and the risk of bias was assessed for each study using Joanna Briggs Institute (JBI) critical appraisal checklist for observational studies. The extracted data from included studies using Microsoft Excel were exported to Stata software version 15.0 for analyses. The overall pooled estimation of outcomes was calculated using a randomeffects model of DerSimonian-Laird method at a 95% confidence level. The heterogeneity of studies was determined using I2 statistics. The presence of publication bias between studies was evaluated using the Begg's and Egger's tests and funnel plot. The protocol of this systematic review and meta-analysis was registered in the Prospero database with reference number ID: CRD42019148481. Results: A total of 5 studies published between the years 2005 and 2018 that met the pre-defined inclusion and exclusion criteria were included. The meta-analysis showed that a significant increase in the risk of liver cirrhosis is associated with aflatoxin exposure (unadjusted pooled odds ratio (OR) = 3.35, 95% CI: 2.74-4.10, p = 0.000; I 2 = 88.3%, p = 0.000; adjusted OR = 2.5, 95% CI: 1.84-3.39, p = 0.000; I 2 = 0%, p = 0.429). Conclusions: The present meta-analysis suggests that aflatoxin exposure is associated with a higher risk of liver cirrhosis.

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“…The blood sample analysis of the worker revealed a doubling of vitamin C and Zn concentration and reduction of serum marker enzymes, i.e., aspartate aminotransferase (AST), alkaline phosphatase (ALP), and GST in most of the individuals. 123 The effect was suggested due to the antioxidant effect of supplementation against AFB1. Vitamin E also exerted protective effects against AFB1-induced nephrotoxicity in rats.…”

Section: Cellular Effectsmentioning

confidence: 99%

Food Mycotoxins: Dietary Interventions Implicated in the Prevention of Mycotoxicosis

Sharma

Patial

2021

ACS Food Sci. Technol.

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Mycotoxins are naturally occurring secondary metabolites produced by molds. These pose a severe health risk to humans and livestock, leading to substantial economic losses. Mycotoxin contamination in various food products is alarming for the global availability and safety of food products. Aflatoxins, ochratoxins, fumonisins, zearalenone, trichothecenes, and ergot alkaloids are major mycotoxins of health and economic importance. The present Review gives an overview of the mechanism of mycotoxin-induced toxicity with an emphasis on cellular and organelle damage in the context of major classes of mycotoxins. Recent advancements in dietary interventions and their mechanism of action against mycotoxin-induced oxidative stress are also discussed in detail. Further, biochemical degradation or biotransformation of mycotoxins by microbial sources is also explored. The direct or indirect exposure of fungal-contaminated food leads to mycotoxicosis. Natural dietary compounds contain various non-nutritive active molecules having significant antioxidant potential and medicinal properties. Many researchers have revealed several active molecules and herbal extracts with potent antioxidant potential to reverse the adverse effect of mycotoxins with substantial success. Therefore, dietary interventions could be a promising method to counter the harmful effects of mycotoxins in the future.

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Role of antioxidant supplementation in oxidant/antioxidant status and hepatotoxic effects due to aflatoxin B1 in wheat miller workers

Cited by 9 publications

References 33 publications

Effects of Prenatal Exposure to Aflatoxin B1: A Review

Effects of Prenatal Exposure to Aflatoxin B1: A Review

Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis

Food Mycotoxins: Dietary Interventions Implicated in the Prevention of Mycotoxicosis

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