The relationship of acidosis and growth retardation

Cooke, Robert E.; Boyden, Douglas G.; Haller, Evelyn C.

doi:10.1016/s0022-3476(60)80240-5

Cited by 54 publications

(17 citation statements)

References 14 publications

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“…Acidosis was considered one important factor, and this has been supported by clinical as well as experimental evidence [2,5]. In our study, acidosis did not seem to have a primary role in causing short stature of children with chronic renal disease.…”

Section: Commentsupporting

confidence: 74%

“…The first group represented normal growth whereas the second represented profound growth failure. No differences were found between children with profound growth failure and those with normal growth (Table II) in regard to (1) blood pressure, (2) presence or absence of anemia, (3) azotemia, (4) sever- ity of acidosis, and (5) concentrating ability of the kidney. Most patients in each group had specific gravities below 1.010, and all patients had specific gravities below 1.018.…”

Section: Total Groupmentioning

confidence: 92%

“…Factors contributing to short stature in children with renal disease have been investigated by several groups [1,2,10,13]. Acidosis and chronic malnutrition were believed to be among the most important causes of the growth failure.…”

Section: Introductionmentioning

confidence: 99%

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A Review: Short Stature in Renal Disease

Stickler

Bergen

1973

Pediatr Res

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Section: Commentsupporting

confidence: 74%

Section: Total Groupmentioning

confidence: 92%

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A Review: Short Stature in Renal Disease

Stickler

Bergen

1973

Pediatr Res

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“…T h e suggestion that uremia may lead to increased energy requirements needs to be studied by paired feeding experiments, for, if substantiated, it might mean that the estimated calorie requirements of the child with uremia are greater than realized. Paired feeding studies on acidotic rats [5] have demonstrated considerably increased energy requirements, and this would be one factor to be investigated in further experiments using this model. I t is hoped that the model developed in the present experiments will prove useful in investigating the various factors such as hypertension, acidosis, osteodystrophy, hormonal alterations, protein calorie malnutrition, etc.…”

Section: Methodsmentioning

confidence: 99%

A Rat Model for the Study of Growth Failure in Uremia

1974

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ExtractThe growth of children with chronic renal disease is poor and the cause of this stunting is not known. Various factors have ben implicated and it is difficult to evaluate their relative importance in clinical studies. Accordingly, there is a need for an animal model, preferably one which enables the effect on growth of a number of factors to be studied separately and over a reasonably short period of time. The growth and food intake of male and female rats rendered uremic by 34 nephrectomy was observed between 40 and 70 days of age for male rats and between 35 and 70 days of age for female rats. Final mean body weight for males with uremia (243 g f 32 g) was significantly less than for control males (323 g f 24 g); final mean body weights for female rats were also significantly different (1 72 g & 17 g; 223 g k 2 1 g). The differences in body weight were apparent from 50 days onwards. Final tail length was significantly less in female uremic rats compared with their control subjects (1 73 mm f 8 mm; 183 mm f 7 mm). Uremic rats matched for body weight with control rats consumed significantly fewer calories; for both groups the average difference was about 15%. Multiple regression analysis of weight gain against age and calorie intake suggests that there may be an increase in the calorie cost of growth in rats with uremia, but these findings require confirmation in paired feeding studies.

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“…West and Smith (27) have shown that the acidosis in chronic renal disease may be an important factor in reducing the growth rate. Cooke et al (5), in a well controlled study in pair-fed rats, also found reduced skeletal growth when the animals were made acidotic with NH,CI and acetazolamide. Strict maintenance of acid-base equilibrium may thus potentiate growth toward the intrauterine rate.…”

Section: Discussionmentioning

confidence: 92%