A Review: Short Stature in Renal Disease

Stickler, Gunnar B.; Bergen, Barry J.

doi:10.1203/00006450-197312000-00006

Cited by 63 publications

(9 citation statements)

References 7 publications

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“…Delayed growth is common in children with CKD and has been associated with chronic acidosis, malnutrition, secondary hyperparathyroidism, and low levels of somatomedin (18). Similarly, multiple bone deformities are common in children and appear to be related to the high rates of bone remodeling associated with hyperparathyroidism.…”

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confidence: 99%

The Case for Routine Parathyroid Hormone Monitoring

Sprague

Moe

2013

Clinical Journal of the American Society of Nephrology

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SummaryParathyroid hormone (PTH) is a uremic toxin with multiple systemic effects including bone disorders (renal osteodystrophy), myopathy, neurologic abnormalities, anemia, pruritus, and cardiomyopathy. Hyperparathyroidism is common in CKD and results in significant morbidity and mortality if left untreated. Clinical practice guidelines from the Kidney Disease Improving Global Outcomes initiative broadened the optimal PTH range to >2 and <9 times the upper limit of normal for the assay measured. Furthermore, the guidelines recommend following trends in PTH to determine the appropriate therapy. These guidelines overcome issues with the assay variability and help clinicians make judgments when treating individual patients. They also require frequent measurement in order to determine trends and implement appropriate treatments.

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confidence: 99%

The Case for Routine Parathyroid Hormone Monitoring

Sprague

Moe

2013

Clinical Journal of the American Society of Nephrology

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“…In infants and children with persisting classic (Type 1) renal tubular acidosis (RTA)I (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), the occurrence of stunted growth is characteristic (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). In these patients, persisting acidosis might be critical to the causation of stunted growth (21-24, 27, 28, 31).…”

Section: Introductionmentioning

confidence: 99%

“…And in a recently described infant girl with classic RTA, the occurrence of stunted growth was not prevented by alkali therapy administered in the amount of2.5 meq/kg per day, even though this dosage was initiated on the third day of life (32). Therefore, in children with classic RTA, either acidosis is not critical to the causation of stunted growth (33) or provision of alkali therapy in the amount of 1-3 meq/kg per day will not predictably sustain correction of acidosis (31). In many infants with apparently classic RTA described in the older literature, several times this dosage of alkali was required to correct acidosis (2,(38)(39)(40)(41)(42)(43)(44)(45)(46)(47).…”

Section: Introductionmentioning

confidence: 99%

Attainment and Maintenance of Normal Stature with Alkali Therapy in Infants and Children with Classic Renal Tubular Acidosis

McSherry¹,

Rc²

1978

J. Clin. Invest.

268

120

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“…We have also observed sud den growth failure in 5 patients who did not undergo diversion (table 3). Again, the mechanism for this process is unknown but may involve a number of factors [16][17][18]: acidosis; abnormal metabolism of calcium, vitamin D and phosphorus; inability to utilize proteins, and caloric insufficiency. Complete relief of obstruction before birth may somehow favorably influence the kidney in its rela tion to growth.…”

Section: Discussionmentioning

confidence: 99%

Normal Growth with Renal Insufficiency Owing to Posterior Urethral Valves: Value of Long-Term Diversion

1992

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Twenty-five patients with posterior urethral valves have been monitored for 10-29 years (mean 18 years). Eight underwent diversion because of impaired renal function (creatinine > 0.8 mg/dl) accompanied by unimproved upper tract form and function after valve ablation. In the nondiverted group, 6 patients (35%) progressed to renal failure; in the diverted group 5 patients (63%) did so (p = 0.30). Of 13 patients whose lowest serum creatinine in the first year after valve ablation was > 0.8 mg/dl, 9 (69 %) went on to renal failure (p = 0.02); in the remaining 12 patients, only 2 (17%) did so (p = 0.008). The mean age for renal failure was 13 years for both groups. The Tanner scale rating (mean percent height) for all patients at 10 years was 61% for the diverted group and 35% for those without diversion (p = 0.004). When the patients treated after the age of 1 year (n = 7) were excluded from the calculation, the rating remained different (54% diversion, 26% no diversion; p = 0.012). We conclude that the boy born with urethral valves and serious upper tract damage is at risk for renal failure, especially during the teen years. An undefined relationship appears to exist between urinary obstruction and growth. In our study, the boys who underwent diversion continued to grow along a normal Tanner height curve.

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A Review: Short Stature in Renal Disease

Cited by 63 publications

References 7 publications

The Case for Routine Parathyroid Hormone Monitoring

The Case for Routine Parathyroid Hormone Monitoring

Attainment and Maintenance of Normal Stature with Alkali Therapy in Infants and Children with Classic Renal Tubular Acidosis

Normal Growth with Renal Insufficiency Owing to Posterior Urethral Valves: Value of Long-Term Diversion

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