The relationship of a high level of serum beta-hydroxybutyrate to cause of death

Kanetake, Jun; Kanawaku, Yoshimasa; Mimasaka, Sohtaro; Sakai, Jun; Hashiyada, Masaki; Nata, Masayuki; Funayama, Masato

doi:10.1016/j.legalmed.2005.01.003

Cited by 50 publications

(31 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During ketoacidosis, BHB is found in the highest concentrations and seems to be the most specific post-mortem marker of ketoacidosis [5,8,[67][68][69]. Therefore, BHB has been well studied in VH [6,8,69].…”

Section: Glucose and Ketonesmentioning

confidence: 99%

Vitreous Humor: A Short Review on Post-mortem Applications

J¹

2015

J Clin Exp Pathol

View full text Add to dashboard Cite

Vitreous humor has been investigated since the 1960s, with many debates occurring over the years with regard to the usefulness of its specific applications. The composition of several electrolytes in post-mortem vitreous humour has been extensively studied. Using the fluid for determining the cause of death has also become commonplace, including testing glucose levels of diabetic related deaths, as well as alcohol and drug related fatalities. The debate regarding the composition between two eyes of the same individual has been an issue in the past, but has since been resolved.

show abstract

Section: Glucose and Ketonesmentioning

confidence: 99%

Vitreous Humor: A Short Review on Post-mortem Applications

J¹

2015

J Clin Exp Pathol

View full text Add to dashboard Cite

show abstract

“…Postmortem investigations of ketone bodies in blood and other biological fluids have been performed by several authors in order to diagnose ketoacidosis as the cause of death [4,33,[46][47][48][49].…”

Section: Ketone Bodies and Diabetic Ketoacidosismentioning

confidence: 99%

“…Kanetake et al [48] investigated levels of 3HB and acetone in the postmortem serum of 100 forensic cases and concluded that in cases without anatomical or toxicological causes of death, the measurement of ketone body levels could be informative. They also proposed that 3HB serum levels over 1,000 μmol/l (10.4 mg/dl) could indicate ketoacidosis as the cause of death in cases showing physical conditions characterized by a tendency to increases in ketone body concentrations.…”

Section: Ketone Bodies and Diabetic Ketoacidosismentioning

confidence: 99%

See 1 more Smart Citation

Postmortem chemistry update part I

2011

View full text Add to dashboard Cite

Postmortem chemistry is becoming increasingly essential in the forensic pathology routine and considerable progress has been made over the past years. Biochemical analyses of vitreous humor, cerebrospinal fluid, blood and urine may provide significant information in determining the cause of death or in elucidating forensic cases. Postmortem chemistry may essentially contribute in the determination of the cause of death when the pathophysiological changes involved in the death process cannot be detected by morphological methods (e.g. diabetes mellitus, alcoholic ketoacidosis and electrolytic disorders). It can also provide significant information and useful support in other forensic situations, including anaphylaxis, hypothermia, sepsis and hormonal disturbances. In this article, we present a review of the literature that covers this vast topic and we report the results of our observations. We have focused our attention on glucose metabolism, renal function and electrolytic disorders.

show abstract

“…are usually a fatty liver with or without fibrosis, elevated levels of β-hydroxybutyric acid and insignificant blood alcohol (2,6). We have previously reported only 1 case that documented the progress of a patient with sudden cardiac arrest due to AKA (7).…”

Section: Alcoholic Ketoacidosis (Aka) Occurs Following Prolonged Excementioning

confidence: 99%