The Relationship Between the Serum Level of Vitamin D and Vitiligo

Khurrum, Huma; AlGhamdi, Khalid M.

doi:10.1177/1203475415610071

Cited by 24 publications

(27 citation statements)

References 27 publications

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“…Khurrum and AlGhamdi [1] found that there was no difference in vitamin D serum levels between vitiligo patients and controls. The authors added that vitamin D deficiency within vitiligo patients was more manifest in those with younger age, male gender, short disease duration, and lack of phototherapy.…”

Section: Discussionmentioning

confidence: 99%

“…The link between vitiligo and vitamin D levels still needs to be investigated more thoroughly. Whether a deficit in vitamin D levels plays a role in inducing vitiligo, as it does in other autoimmune disorders, is not yet clear [1].…”

Section: Introductionmentioning

confidence: 99%

“…Its main etiology is still obscure. Some theories include autoinflammatory, autoimmune, neural, genetic, cytotoxic, and metabolic etiologies [1]. Lately, there has been a rising awareness regarding the role of the active form of vitamin D, 1,25-dihydroxyvitamin D 3 [1,25(OH) D], in the pathogenesis of vitiligo and its impact in the treatment of this disorder [2].…”

Section: Introductionmentioning

confidence: 99%

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Is There a Relation between Vitamin D and Interleukin-17 in Vitiligo? A Cross-Sectional Study

Aly

Mohammed²,

Sayed³

et al. 2017

Dermatology

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Background: High interleukin (IL)-17 contributes to vitiligo pathogenesis. Vitamin D has been assessed in vitiligo, with no reports targeting its relation to IL-17. Objective: To evaluate a possible regulatory effect of vitamin D on IL-17 and their relation to disease activity in vitiligo. Methods: This study included 30 vitiligo patients and 40 controls evaluated for IL-17 and vitamin D serum levels by ELISA technique. Results: IL-17 was significantly higher (p = 0.001) whereas vitamin D was found to be lower among the patients (p < 0.001). Multivariable regression was performed to evaluate the relationship between IL-17 and vitamin D levels with the demographic data on the patients, revealing a nonsignificant relationship (p > 0.05). A significant positive correlation was noted between vitamin D levels and disease duration. Conclusion: Vitamin D represents a potential player in the pathogenesis of vitiligo. Its possible regulatory relation to IL-17, together with its weight as a screening tool in vitiligo, needs further evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is There a Relation between Vitamin D and Interleukin-17 in Vitiligo? A Cross-Sectional Study

Aly

Mohammed²,

Sayed³

et al. 2017

Dermatology

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“…[12][13][14][15][16][17][18][19][20] There was no significant decrease in vitamin D levels in patients with associated autoimmune comorbidity in our study. Similar results have been found by Khurrum et al, Saleh et al as well as Beheshti et al 7,18,19 All other studies had found a significant decrease in vitamin D levels in patients having comorbid autoimmune conditions. 12-20, Further studies having a larger sample size may reveal a correlation in the Indian context.…”

Section: Discussionmentioning

confidence: 73%

“…Similar results were obtained in a study by Finamor et al as well as Takczi et al 9,11 However the majority of patients in other studies had a mean age below 35. [6][7][8][12][13][14][15][16][17][18][19][20] This may reflect certain social attitudes towards the disease i.e. hesitancy to consult local physicians regarding vitiligo, or presenting to a tertiary center only after prolonged native treatment.…”

Section: Discussionmentioning

confidence: 99%

A case control study of vitamin D levels in patients with vitiligo

Karthikeyan

2017

Int J Res Dermatol

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Background: Vitiligo is fairly commonly encountered disorder of pigmentation resulting in the presence of numerous depigmented macules and patches over the body. Vitamin D is an essential hormone synthesized in the skin. Levels of vitamin D have been found to be low in patients with vitiligo. The purpose of this study is to evaluate if vitamin D levels have any association with vitiligo, by estimating the levels of vitamin D in patients with vitiligo, and correlating type of vitiligo with vitamin D levels.Methods: A hospital based case control study was done in the Dermatology outpatient department of a tertiary center in South India from October 2014 to May 2016. About 45 consenting patients who fulfilled the inclusion criteria were chosen for the study. About 45 age and sex matched consenting individuals without vitiligo were chosen as controls from the Dermatology outpatient department. A detailed history and clinical examination of all the consenting subjects was done. Blood samples were collected from both the cases and controls by venepuncture and sera separated. The levels of Vitamin D were estimated using a vitamin D ELISA kit.Results: There was no statistically significant difference in vitamin D levels between patients and controls. There was no correlation between type of vitiligo and vitamin D value. Conclusions: Vitamin D does not appear to have any role in vitiligo patients in this study.

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Serum vitamins and trace elements in vitiligo patients: A systematic review and meta‐analysis of observational studies

Iraji,

Seyedyousefi,

Heidari

2024

JEADV Clinical Practice

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Vitiligo is one of the most common pigmentary skin disorders, which significantly impacts the quality of life. The aetiology and pathophysiology of vitiligo are still unclear, but one of the proposed mechanisms is oxidative damage interrupting melanogenesis. The purpose of this study was to demonstrate the serum levels of trace elements and vitamins and to systematically review the evidence comparing vitiligo patients with a healthy group. We comprehensively retrieved all studies related to vitiligo and the serum levels of vitamins and minerals from databases such as PubMed, EMBASE, Scopus, Web of Science, Magiran, SID and ISC up to December 2022. Quality assessment and data extraction were conducted by two independent reviewers. Pooled standard mean differences with 95% confidence intervals were estimated using random‐effects models. Our meta‐analysis revealed no significant differences in serum levels of Vitamin B12 and copper. It was concluded that serum concentrations of Vitamin D, Vitamin E, and zinc were lower in vitiligo patients. Conversely, these patients exhibited higher levels of selenium and folic acid compared with healthy individuals. These results might affect the potential use of vitamin and mineral supplementation in vitiligo treatment.

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The Relationship Between the Serum Level of Vitamin D and Vitiligo

Abstract: There is no difference between the vitamin D levels of the vitiligo patients and the control subjects. However, deficiency of 25(OH)D levels within the vitiligo subgroups may be linked to younger age, male gender, short duration of vitiligo, and non-use of phototherapy.

Cited by 24 publications

References 27 publications

Is There a Relation between Vitamin D and Interleukin-17 in Vitiligo? A Cross-Sectional Study

Is There a Relation between Vitamin D and Interleukin-17 in Vitiligo? A Cross-Sectional Study

A case control study of vitamin D levels in patients with vitiligo

Serum vitamins and trace elements in vitiligo patients: A systematic review and meta‐analysis of observational studies

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