The Relationship between the progression of colorectal cancer and microRNA polymorphisms

Abstract

Purpose : MicroRNA(miRNA) is related not only with basic biologic process but with regulatory functions of diverse diseases including cancer. Although it is non-coding RNA of small nucleotides(18~23), nucleotide variation within primary(pri)-or precursor(pre)-miRNA might affect the mature process of miRNA and can cange it. And then we aim to elucidate the relationship between 4 kinds of pre-miRNA and clinical progress of colorectal cancer such as tumor stage, depth of invasion and regional lymph nodes metastasis.Methods : DNA was extracted from blood samples of 160 patients who underwent operation on colorectal cancers during recent 2 years and has-mir-146aC>G, has-mir-149T>C, has-mir-196a2T>C and has-mir-499A>G polymorphisams were genotyped by PCR-RFLP.Results : There was no relationship between the polymorphism distributions of 4 kinds of pre-miRNA and any clinical progresses of colorectal cancer.Conclusion : Although we were unable to find out significant relation between two categories, further active studies with miRNAs and cancers shoud be carried on.

Expression of MicroRNA-221 in Korean Patients with Multiple Myeloma

“…In one study comparing plasma miRNA profile between MM patients and healthy controls, six miRNAs (miR-148a, miR-181a, miR-20a, miR-221, miR-625, and miR-99b) were found upregulated in MM patients. Notably, miR-15a, miR-16, miR-181a, miR-20a, miR-221, and miR625 were identified previously to be unregulated in the plasma cells of MM or MGUS [17][18][19][20][21][22][23]. Importantly, there have been no studies examining miRNA expression in Korean patients with MM.…”