The Relationship between the BRAF Mutations in Thyroid Papillary Carcinomas and the Prognostic Factors

Rha, So Young; Lee, Jun Chul; Kwon, Kui Hyang; Kim, Koon Soon; Jo, Young Suk; Ku, Bon Jeong; Shong, Minho; Kim, Young Kun; Ro, Heung Kyu

doi:10.3803/jkes.2005.20.3.224

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…However, previous reports indicated no significant difference in extrathyroidal extension, LN metastasis, and multifocality between the two groups. 26 , 27 , 28 We think that the lack of association between the BRAF V600E mutation and some poor clinicopathologic factors might have resulted from the small number of cases and/or large number of micro-PTCs (28 of 72, 38.9%), and different prevalence of BRAF V600E mutation. Therefore, further studies with a larger patient population may be necessary to determine clinical utilities such as diagnosis and prognosis in patients with PTC.…”

Section: Discussionmentioning

confidence: 99%

Detection of Plasma BRAF^V600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas

Kim

Lee

et al. 2015

Yonsei Med J

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PurposeThe BRAFV600E mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid carcinoma (PTC). The purpose of this study was to determine the clinical significance of free circulating mutant BRAFV600E in predicting the advanced disease of PTC.Materials and MethodsSeventy seven matched tumor and plasma samples obtained from patients with both benign and PTC were analyzed for BRAFV600E mutation using a peptide nucleic acid (PNA) clamp real-time polymerase chain reaction (PCR).ResultsThe BRAFV600E mutation was absent in tumor DNA samples obtained from patients with benign follicular adenomas or adenomatous goiter. In contrast, 49 of 72 (68.1%) PTC tumors were positive for the BRAFV600E mutation. Among them, 3 (6.1%) patients with PTC were positive for BRAFV600E mutation in plasma and tumor. However, all 3 patients (100%) had lateral lymph node and lung metastasis.ConclusionThese findings suggest that the BRAFV600E mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis. Future studies are warranted to determine clinical significance of serum BRAFV600E mutation in large prospective studies.

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Section: Discussionmentioning

confidence: 99%

Detection of Plasma BRAF^V600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas

Kim

Lee

et al. 2015

Yonsei Med J

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Pitfalls in Molecular-Based Diagnoses Using Thyroid Aspirates in Korea

Pyo

Hong

2019

Thyroid FNA Cytology

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BRAFV600E mutation does not serve as a prognostic factor in Korean patients with papillary thyroid carcinoma

et al. 2012

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The Relationship between the BRAF Mutations in Thyroid Papillary Carcinomas and the Prognostic Factors

Abstract: Background: Thyroid cancers account for about 1% of all human malignancies, with papillary thyroid carci-

Cited by 6 publications

References 18 publications

Detection of Plasma BRAF^V600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas

Detection of Plasma BRAF^V600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas

Pitfalls in Molecular-Based Diagnoses Using Thyroid Aspirates in Korea

BRAFV600E mutation does not serve as a prognostic factor in Korean patients with papillary thyroid carcinoma

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The Relationship between the BRAF Mutations in Thyroid Papillary Carcinomas and the Prognostic Factors

Abstract: Background: Thyroid cancers account for about 1% of all human malignancies, with papillary thyroid carci-

Cited by 6 publications

References 18 publications

Detection of Plasma BRAFV600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas

Detection of Plasma BRAFV600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas

Pitfalls in Molecular-Based Diagnoses Using Thyroid Aspirates in Korea

BRAFV600E mutation does not serve as a prognostic factor in Korean patients with papillary thyroid carcinoma

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Product

Resources

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Detection of Plasma BRAF^V600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas

Detection of Plasma BRAF^V600EMutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas