The Relationship between the Blood Level of Persistent Organic Pollutants and Common Gastrointestinal Symptoms

Abstract

Background: Persistent organic pollutants (POPs) are toxic materials that cannot be broken down naturally and that easily accumulate in the body. Although several studies have attempted to uncover the effects of POPs on the endocrine and nervous systems and on cancer, few focus on the relationship between low-dose POPs and public health. Here, we attempt to determine the relationship between the level of POPs and common gastrointestinal symptoms, including abdominal discomfort, diarrhea, and constipation. Methods: We recruited 121 subjects who visited Kyungpook National University Medical Center for health screening. Plasma concentrations were evaluated for 40 kinds of POPs including 17 types of polychlorinated biphenyls (PCBs) and 23 types of organochlorine pesticides (OCP). Furthermore, the Korean version of the Rome III criteria was used to identify gastrointestinal symptoms. Results: Based on our results, abdominal discomfort showed an inverse relationship with several PCBs and an inverted U-shaped relationship with several other OCPs including pp-DDD and pp-DDT. The effects of pp-DDD and pp-DDT on abdominal discomfort were similar to those of OCPs on obesity and metabolic syndrome. Conclusion: Our results suggest that mild and unspecified gastrointestinal symptoms with no clear causes could be related to POP levels.

The role of chemical exposures in reducing the effectiveness of water–sanitation–hygiene interventions in Bangladesh, Kenya, and Zimbabwe

“…For example, recent studies in Bangladesh (Miah, Hoque, Paul, & Rahman, 2014), Thailand (Sapbamrer & Nata, 2014), Tanzania (Manyilizu et al, 2017), and Pakistan (Tarar et al, 2019) have revealed increased incidences of diarrhea (and other ailments) among farmers occupationally exposed to pesticides. A number of studies have found gastrointestinal symptoms including diarrhea statistically correlated with exposure to organochlorine and organophosphorus pesticides, and PCBs^ (Alam et al, 2015;Islam et al, 2018;Kim, Youn, Ko, Lee, & Lee, 2017;Manyilizu et al, 2017;Miah et al, 2014). Phthalates, parabens, and phenols such as bisphenol-A (BPA) are found in a wide variety of consumer products such as plastics, detergents and cleaning products, paints, pharmaceuticals, cosmetics, soaps, toothpaste, and other personal care products (PCPs), and some canned and processed foods.…”