The Relationship between the Antioxidant System and Anaemia in Haemodialysis Patients

Çelik, Gülperi; Yöntem, Mustafa; Bilge, Murat; Cilo, Mustafa; Ünaldı, Mustafa

doi:10.1177/147323001103900541

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…The eSS rats had also a significantly lower number of white cells than in controls. Differential count also showed a pattern of lymphopenia and neutrophilia as was reported in critically ill hyperglycemic patients [25,26]. These white blood cell changes possibly contribute to the increased susceptibility to infection reported for the eSS rats [27].…”

Section: Discussionsupporting

confidence: 57%

Anemia in Spontaneously Type 2 Diabetic Rats With Renal Impairment

Danièle

2012

J Endocrinol Metab

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Background:The eSS rats display a mild non obese type 2 diabetic syndrome with an insulin resistant state characterized by hyperglycemia, dyslipidemia and hyperinsulinemia. During the first year, eSS male rats exhibit proteinuria as well as alterations in glomerular filtration. Methods:In this study, some hematological characteristics were evaluated in 12 month-old eSS males compared to eumetabolic Wistar rats, and the renal histology was also studied. Results:The diabetic rats were found to have fewer erythrocytes and lower values of hemoglobin. In eSS rats, peripheral blood smears showed immature erythrocytes with polychromatophilia and the presence of erythroblasts was also verified. Thickening of the glomerular basement membrane, areas of tubular dilatation and protein cylinders were observed in kidneys of diabetic animals. Conclusions:Our results suggest that eSS rats develop anemia because of complex influences of metabolic disturbances and diabetic renal damage and that it might provide new opportunities for studying the pathogenesis of this relevant complication of type 2 diabetics.

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Section: Discussionsupporting

confidence: 57%

Anemia in Spontaneously Type 2 Diabetic Rats With Renal Impairment

Danièle

2012

J Endocrinol Metab

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“…ESRD patients on maintenance HD treatment are under the risk of increased oxidative stress caused by several mechanisms, as previously outlined. While uremia is capable of inducing oxidative stress, anemia amplifies it 17,18. The mechanisms by which anemia contributes to oxidative stress are not fully understood, but factors such as hypoxia, peroxidation of lipids in the erythrocyte membrane that reduce their life span 19 and altered catecholamine metabolism may play a significant role.…”

Section: Discussionmentioning

confidence: 99%

How the Duration Period of Erythropoietin Treatment Influences the Oxidative Status of Hemodialysis Patients

Dimitrijević¹,

Cvetković²,

Djordjević³

et al. 2012

Int. J. Med. Sci.

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Background: End-stage renal disease is a state of enhanced oxidative stress (OS) and hemodialysis (HD) and renal anemia further augment this disbalance. Anemia correction with erythropoietin (EPO) may improve oxidative status. However, there is no evidence of time dependent effects of EPO therapy on redox status of HD patients.Objective: The aim of this study was to evaluate whether the duration of EPO treatment may affect OS parameters in uremic patients.Patients and methods: 104 HD patients and 29 healthy volunteers were included. Patients were divided into 3 groups according to the duration of EPO treatment. Forth group consisted of HD patients without EPO treatment. Plasma and erythrocyte malondialdehyde (MDA, MDArbc), reactive carbonyl groups (RCG), plasma sulfhydryl (-SH) groups and total antioxidative capacity (TAC) levels were evaluated.Results: HD patients both with and without EPO treatment, showed a significant increase in all oxidative parameters without significance between EPO treated and -untreated group. The decrease in MDA and MDArbc levels coincided with the duration of EPO treatment. A negative correlation was observed between the duration of EPO treatment and serum MDA (r=˗0.309, p=0.003). Increasing periods of EPO treatment were associated with decrease in RCG, without significance between EPO groups. Increase in TAC accompanied increasing durations of EPO treatment, with EPO treatment for more than 24 months causing the most striking changes (p<0.05). There were no significant differences in ˗SH levels between EPO subgroups.Conclusion: Our results suggest that long term administration of EPO attenuated the lipid peroxidation process and restored the levels of antioxidants.

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“…Accumulation of uremic toxins [2], bioincompatibility of the dialyzer's membrane [3], depletion of low molecular antioxidants, in the first place ascorbic acid, during the hemodialysis session [4], and excessive and indiscriminate use of intravenous iron preparations [5] have been described as the main factors which cause oxidative stress in the chronically hemodialyzed patients. There is a large body of evidence that the prooxidant state of the chronically hemodialyzed patients is associated with cardiovascular disease [6–8], renal anemia [9, 10], and mineral and bone disorders [11], which largely contribute to their increased morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Assays for Measurement of Serum (Anti)oxidants in Hemodialysis Patients

Ruskovska

Jansen

Antarorov

2014

BioMed Research International

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Background. Various biomarkers and assays have been used for assessment of (anti)oxidant status in hemodialysis patients, including those intended for measurement of serum total (anti)oxidants, most often as a part of panel biomarkers. Methods. Serum (anti)oxidant status was measured in 32 chronically hemodialyzed patients and in 47 healthy persons, using two oxidations and three antioxidant assays. Results. The patients before the hemodialysis session have had higher values of total oxidants in comparison to the healthy persons, with a further increase during the hemodialysis. These findings were confirmed with both oxidation assays, but they differ in the percentage of increase and the statistical significance. All three antioxidant assays showed significantly higher values of the total serum antioxidants in the patients before the hemodialysis session in comparison to the healthy persons, and their significant decrease during the hemodialysis. However, the assays differ in the percentage of decrease, its statistical significance, and the correlations with uric acid. Conclusion. The variability of results of total (anti)oxidants which are obtained using different assays should be taken into account when interpreting data from clinical studies of oxidative stress, especially in complex pathologies such as chronic hemodialysis.

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The Relationship between the Antioxidant System and Anaemia in Haemodialysis Patients

Cited by 12 publications

References 33 publications

Anemia in Spontaneously Type 2 Diabetic Rats With Renal Impairment

Anemia in Spontaneously Type 2 Diabetic Rats With Renal Impairment

How the Duration Period of Erythropoietin Treatment Influences the Oxidative Status of Hemodialysis Patients

Evaluation of Assays for Measurement of Serum (Anti)oxidants in Hemodialysis Patients

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