The relationship between systolic pressure and stroke volume describes myocardial contractility

Experimental validation of the prestretch-strain relationship as a non-invasive index of left ventricular myocardial contractility

“…Several studies have questioned the performance of ESPVR given that the relationship is not always linear when experimenting in conscious mammals and have recommended other types of non-linear curve fitting in order to obtain a more accurate index of LV contractility [3,5,[10][11][12]14]. However, in our study we found the relationship between end-systolic pressure and volume highly linear (cf.…”

“…Available data from experimental studies on mammals and humans points towards PRSW as the most reliable index due to its load independency, its sensitivity to contractile changes and its low measurement variability [1,3,5,6,7,9]. In contrast, the maximal slope of the dP/dt max -EDV relationship was reported to be load dependent and sensitive to measurement variability while data on E max is contradictory, with some studies reporting a degree of load dependency and non-linearity of the measurement under non-physiologic conditions while others do not [1][2][3][4][5][6][10][11][12][13][14][15]. Of course, the invasive nature by which these parameters are obtained is the most important limitation to its clinical routine use.…”