Experimental validation of the prestretch-strain relationship as a non-invasive index of left ventricular myocardial contractility

Abstract

BackgroundThe slope of the relationship between segmental PreS and total systolic shortening (S) has been proposed as a non-invasive index of left ventricular contractility. The aim of this study was to correlate this novel parameter to invasive gold standard measurements of contractility and to investigate how it is influenced by afterload. OPEN ACCESS Citation: Mirea O, Vallecilla C, Claus P, Rademakers F, D'hooge J (2020) Experimental validation of the prestretch-strain relationship as a non-invasive index of left ventricular myocardial contractility. PLoS ONE 15(2): e0228027. https:// ConclusionsThe slope of the PreS-S relationship is sensitive to changes in inotropy and is less loaddependent than conventional non-invasive parameters of left ventricular function. The magnitude of the change of this slope correlates well with changes in invasive contractility measurements making it an attractive parameter to assess contractile reserve or contractile changes during longitudinal follow-up of patients.Validation of the prestretch-strain relationship as an index of left ventricular contractility PLOS ONE | https://doi.