The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis

Torres, Leah; Dunlop, Dorothy D.; Peterfy, Charles; Guermazi, Ali; Prasad, Pottumarthi V.; Hayes, Karen; Song, Jing; Cahue, September; Chang, Alison H.; Marshall, M.; Sharma, Leena

doi:10.1016/j.joca.2006.03.015

Cited by 321 publications

(293 citation statements)

References 25 publications

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“…Direct X-ray radiography is a suboptimal technique for demonstrating pathologies like synovitis or bone marrow edema, which underlie the joint pain. Torres et al (33) demonstrated that pain intensity correlated with erosion in subchondral bone, bone marrow lesions, synovitis, effusion, and meniscal tear, which are not demonstrable with direct X-ray imaging. Further, radiological grading of the disease could differ on the basis of individual assessment.…”

Section: Discussionmentioning

confidence: 99%

Associated Factors with Pain and Disability in Patients With Knee Osteoarthritis

et al. 2010

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ÖzetAmaç: Diz osteoartriti (OA) olan hastalarda ağrı ve fonksiyonel düzeyle ilişkili etkenleri belirlemektir. Yöntem ve Gereçler: Diz OA tanısı alan 161 hasta çalışmaya alın-dı. Hastaların yaş ortalaması 62.4± 8.7 yıl olup ortalama semptom süresi 43.76± 26.6 aydı. Hastaların yaş, cinsiyet, vücut kütle indeksi, eğitim düzeyi, sigara ve düzenli egzersiz alışkanlığı ve semptom süreleri kaydedildi. Ön-arka ve lateral diz grafilerinde Kellgren-Lawrence skorları hesaplandı. Hastaların fonksiyonel düzeyi Western Ontario ve McMaster Üniversitesi Osteoartrit İndeksi (WOMAC) ile, ağrı şiddeti Görsel Ağrı Skalası (GAS) ile değerlendirildi. Bulgular: Vücut kütle indeksi ile WOMAC ağrı skoru (r=0.592, p=0.0001), WOMAC eklem sertliği skoru (r=0.634, p=0.0001) ve WOMAC günlük yaşam aktiviteleri skoru (r=0.749, p=0.0001) arasında ilişki saptandı. Eğitim düzeyi ile WOMAC ağrı skoru (r=-0.394, p=0.001), WOMAC eklem sertliği skoru (r=-0.345, p=0.004), ve WOMAC günlük yaşam aktiviteleri skoru (r=-0.352, p=0.003) arasında ters ilişki saptandı. Kellgren-Lawrence skoru (ön-arka ve yan grafi) ile GAS skoru ve her üç WOMAC skoru arasında ilişki saptanmadı (p>0.05). Kellgren-Lawrence ön-arka ve yan grafi skorları yaş ve semptom süresiyle ilişkili bulundu (sırasıy-la r=0.263, p=0.001 ve r=0.339, p=0.016). GAS skoru ile herhangi bir parametre arasında ilişki saptanmadı. WOMAC alt grup skorları ve GAS skoru cinsiyete göre karşılaştırıldığında WOMAC ağrı skorunun bayanlarda daha yüksek olduğu saptandı (p= 0.024). Geri kalan faktörlerle WOMAC alt grup skorları arasında korelasyon saptanmadı. Sonuç: Vücut kütle indeksi, diz OA olan hastalarda fonksiyonel düzey ve ağrı şiddetiyle ilişkili en önemli faktördür. Hastalar, semptom ve hastalık şiddetini azaltmak açısından kilo vermeye teşvik edilmelidirler. (Turk J Rheumatol 2010; 25: 77-81 r=-0.394, r=-0.345, and r=-0.352, respectively). Kellgren-Lawrence scores of anteriorposterior and lateral view radiographs were found to be correlated with age and symptom duration (r=0,263, p=0,001 and r=0,339, p=0,016, respectively). No relationship was found between pain VAS scores and any assessed factors.When WOMAC subscale scores and VAS scores were compared according to gender, WOMAC pain scores were found higher in females (p=0.024). No correlation was found between remainder factors and scores of the three sections of WOMAC. Conclusion:The BMI is the most important factor associated with functional level and pain severity of patients with KOA. Patients must be encouraged to loose weight in order to decrease symptom and disease severity. (Turk J Rheumatol 2010; 25: 77-81)

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Section: Discussionmentioning

confidence: 99%

Associated Factors with Pain and Disability in Patients With Knee Osteoarthritis

et al. 2010

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“…This process results in increased stiffness of subchondral bone, flattening of the articular surface, and bone edema (4,6,23). In a cross-sectional study involving 143 patients, Torres et al (24) found that the severity of knee pain was correlated with flattening, BM edema, meniscal tears, and effusions. Hernandez et al (3) noted a significant correlation between the presence of knee pain and flattening (OR, 3.3; 95% CI, 2.5-4.5) in a recent study involving a Framingham OA cohort of 1627 patients.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Pain Severity and Magnetic Resonance Imaging Features in Patients with Osteoarthritis of The Knee

et al. 2010

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Objective: To evaluate the association between clinical symptoms and magnetic resonance imaging (MRI) findings in patients with osteoarthritis (OA) of the knee. Materials and Methods: Ten men and 24 women between 30 and 60 years of age, who fulfilled the American College of Rheumatology (ACR) criteria for knee OA, were included in the study. All patients underwent MRI of the more symptomatic knee and the MRI findings were evaluated by the same radiologist blinded to clinical findings, using a semi-quantitative whole-organ MRI scoring method (WORMS). The Western Ontario and Mc-Master University (WOMAC) osteoarthritis index was used to assess physical function, morning stiffness, and joint pain. Results: Linear regression analysis revealed that the total WORMS score and effusion severity were the most important predictors of the WOMAC pain score. The volume of the effusion was significantly correlated with the WOMAC pain and disability scores (r=0.601, p<0.001; and r=0.626 p<0.001, respectively). There was also a positive correlation between the WOMAC pain score and the WORMS bone marrow edema (BME) score (r=0.508, p<0.01). Patients with synovial effusions had significantly higher WOMAC pain and disability scores compared to patients without synovial effusions (p<0.01 and p<0.001, respectively). Similar results were also observed in patients with BME compared to those without edema. Conclusion: Our results demonstrated that the severity of synovial effusion on MRI was associated with increased pain and disability in knee OA. MRI allows the precise visualization of joint structures, such as cartilage, bone, synovium, ligaments, and menisci, so that the joint can be examined as a whole organ. (Turk J Rheumatol 2010; 25: 184-90 (Turk J Rheumatol 2010; 25: 184-90)

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“…Occupational therapists teach you ways to perform regular, daily activities, such as housework, with less pain. 15,16 The aim of this systemic review was to identify, evaluate and summarize the effectiveness of Rhus tox in management of pain in cases of OA.…”

Section: Physical and Occupational Therapymentioning

confidence: 99%

To study the efficacy of Rhus tox in management of cases of osteoarthritis of knee joint

Rajgurav

Aphale

2016

Int J Res Orthop

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Background: Arthritis and rheumatism are among the commonest forms of chronic disease and, with an aging population, are set to become commoner still. Strictly speaking, arthritis means disease of the joints, while rheumatism is disease of the soft connective tissues which support and move the joints. There are many problems with current conventional treatment of arthritis and rheumatism. Although the new generation of NSAIDs is safer, they are only glorified painkillers, which do not affect the basic disease process. Similarly for rheumatoid arthritis, a range of powerful drugs is available but all of these have long and alarming lists of side effects. Thus the main aim of this research study is to prove the efficacy of Homoeopathy in managing cases of Osteoarthritis without any side-effects.Methods: 30 cases were selected fitting the case definition. Age group of 45-79 years was chosen for the study. Inclusion and exclusion criteria were laid down. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren and Lawrence system of classifying the severity of knee-osteoarthritis were used to assess the severity and outcome.Results: All the results were tabulated. Graphical presentation was made of all the observations. Scores before and after treatment was compared. It was found that there was vast difference in scores before and after treatment. Conclusions: Rhus tox was found to be effective in managing cases of Osteoarthritis of Knee Joint.

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The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis

Abstract: In persons with knee OA, knee pain severity was associated with subarticular bone attrition, bone marrow lesions, synovitis/effusion, and meniscal tears. The contribution of bone marrow lesions to pain severity appeared to require the presence of bone attrition.

Cited by 321 publications

References 25 publications

Associated Factors with Pain and Disability in Patients With Knee Osteoarthritis

Associated Factors with Pain and Disability in Patients With Knee Osteoarthritis

Relationship Between Pain Severity and Magnetic Resonance Imaging Features in Patients with Osteoarthritis of The Knee

To study the efficacy of Rhus tox in management of cases of osteoarthritis of knee joint

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