The relationship between serum visfatin, adiponectin, and insulin sensitivity markers in neonates after birth

Meral, Cihan; Çekmez, Ferhat; Pirgon, Özgür; Tanju, İlhan Asya; İpçioğlu, Osman Metin; Karademır, Ferhan; Göçmen, İsmail

doi:10.3109/14767058.2010.482604

Cited by 23 publications

(11 citation statements)

References 24 publications

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“…Visfatin is produced mainly in the adipose tissue, and its concentration is related to the total body fat mass. 17,18 Although it is possible that visfatin is a marker of fat accumulation, no study to date has reported any association between visfatin levels and the established endocrine regulators of fetal growth, IGF-I, and insulin. 19 Consistent with this, we found no correlation between visfatin levels and those of other adipocytokines including IGF-I.…”

Section: Discussionmentioning

confidence: 99%

The Role of Umbilical Cord Blood Concentration of IGF-I, IGF-II, Leptin, Adiponectin, Ghrelin, Resistin, and Visfatin in Fetal Growth

et al. 2018

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Objective Herein, we measured the concentration of insulinlike growth factor I (IGF-I), IGF-II, leptin, adiponectin, ghrelin, resistin, and visfatin in the umbilical cord blood of newborns categorized as “small for gestational age” (SGA), “appropriate for gestational age” (AGA), and “large for gestational age” (LGA). Our aim was to elucidate the link between the levels of these proteins and fetal growth. Study Design A total of 96 term infants were included and categorized into three weight categories. Their venous cord blood samples were collected to measure the levels of IGF-I, IGF-II, leptin, adiponectin, ghrelin, resistin, and visfatin. Results IGF-I, visfatin, and leptin levels showed significant differences among the groups. Pairwise comparisons showed that adiponectin (p = 0.023), resistin (p = 0.025), and ghrelin (p = 0.005) levels were significantly lower in the SGA group than in the LGA group. Correlation analyses showed a strong association of IGF-1, IGF-II, and leptin levels with birth weight (r = 0.644, p < 0.001; r = 0.441, p < 0.001; and r = 0.404, p < 0.001, respectively). Conclusion SGA newborns showed a significantly higher visfatin concentration and lower ghrelin, leptin, resistin, and adiponectin levels than the AGA and LGA newborns did.

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Section: Discussionmentioning

confidence: 99%

The Role of Umbilical Cord Blood Concentration of IGF-I, IGF-II, Leptin, Adiponectin, Ghrelin, Resistin, and Visfatin in Fetal Growth

et al. 2018

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“…An NOS score of 5 or 6 stars in all of the studies suggested the inclusion of good quality studies [8-17]. With the exception of one study conducted by Kyriakakou et al[11], which used RIA kits, maternal blood or cord adiponectin concentrations were measured using ELISA kits in all studies [8-10, 12-17]. …”

Section: Resultsmentioning

confidence: 99%

Maternal and Cord Blood Adiponectin Concentrations in Small for Gestational Age: A Meta-Analysis

Goto¹

2017

Ann Nutr Metab

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Background: Adiponectin, which may have a growth-promoting effect through its insulin-sensitizing action, is thought to play a key role in fetal growth. This study was performed to determine whether maternal and/or cord blood adiponectin concentrations differ between small for gestational age (SGA) and healthy controls. Methods: Databases were searched to identify good quality English language studies providing the number of SGA and healthy controls, and the means and standard deviations of maternal or cord blood adiponectin concentration in both groups. A meta-analysis was performed to summarize the standardized mean differences (SMDs) in maternal and cord blood adiponectin concentrations between SGA and healthy controls. Results: There was no statistically significant difference in maternal blood adiponectin concentration between SGA and healthy controls (n = 8, p = 0.951). However, cord blood adiponectin concentration was significantly lower in SGA than in healthy controls (n = 6, p = 0.028), and the effect was large (i.e., SMD >0.7). Conclusions: Maternal blood adiponectin concentration is not low in SGA compared with healthy controls. However, SGA shows lower cord blood adiponectin concentration than healthy controls.

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“…LGA, SGA, and LBW newborns have an increased risk for developing metabolic syndrome in adulthood. 49 Recently, however, it has been reported that preterm newborn, whether SGA or AGA, with normal BMI, did not show insulin resistance in childhood. There were no detected…”

Section: Visfatin In Iugr and Sga Newbornsmentioning

confidence: 99%

“…45 Precisely, hypoadiponectinemia has been shown to be associated with insulin resistance, 46 leptin may influence the "programming" of satiety, 47,48 and visfatin can increase in parallel with hyperglycemia for insulin-like effect. 49 In fact, several studies demonstrated that higher maternal plasma visfatin concentration is associated with insulin resistance, gestational diabetes mellitus (GDM), patients with small-for-gestational-age (SGA), 50,51 and neonates with intrauterine growth restriction (IUGR). 52…”

Section: Visfatin and Pregnancymentioning

confidence: 99%

The Role of Visfatin in Pregnancy, Complications and Procreation

et al. 2015

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Adipose tissue is considered an endocrine organ secreting numerous neuroendocrine and peripheral peptides, also known as ?adipokines.? Although, the role of adipokines, precisely visfatin, is still controversial, it was recently discovered their involvement in different mechanisms, including metabolism, inflammation, and endocrine-immunologic system. A literature search of electronic databases was undertaken for the major studies published from 1957 to present. The databases searched were: PubMed, EMBASE, Orphanet, Midline, and Cochrane Library. This review aims to emphasize the molecular and endocrine mechanisms of visfatin and its role in fetal development. This review also reviews the role of adipocytokine in the pathogenesis of inflammatory-endocrine disorders. Further research will bring new insight into linkage between visfatin and humans, during pregnancy and perinatal period.

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The relationship between serum visfatin, adiponectin, and insulin sensitivity markers in neonates after birth

Cited by 23 publications

References 24 publications

The Role of Umbilical Cord Blood Concentration of IGF-I, IGF-II, Leptin, Adiponectin, Ghrelin, Resistin, and Visfatin in Fetal Growth

The Role of Umbilical Cord Blood Concentration of IGF-I, IGF-II, Leptin, Adiponectin, Ghrelin, Resistin, and Visfatin in Fetal Growth

Maternal and Cord Blood Adiponectin Concentrations in Small for Gestational Age: A Meta-Analysis

The Role of Visfatin in Pregnancy, Complications and Procreation

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