The Role of Visfatin in Pregnancy, Complications and Procreation

Marseglia, Lucia; Manti, Sara; Cuppari, Caterina; Salpietro, Vincenzo; Filippelli, Martina; Chirico, Valeria; Gitto, Eloisa; Salpietro, Carmelo; Arrigo, Teresa

doi:10.1055/s-0035-1554783

Cited by 10 publications

(9 citation statements)

References 71 publications

(96 reference statements)

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“…Visfatin, a relatively recently discovered adipokine, is mostly expressed in human visceral fat [ 38 , 39 ] although it is synthesized by bone marrow, liver, lungs, skeletal muscle, brain, heart, pancreas, and peripheral blood lymphocytes. Plasma visfatin levels have been positively correlated with body fat mass and concentration decreases when weight loss occurs [ 40 ].…”

Section: Oxidative Stress and Obesitymentioning

confidence: 99%

Oxidative Stress in Obesity: A Critical Component in Human Diseases

Marseglia

Manti

Nicotera

et al. 2014

IJMS

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760

512

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Obesity, a social problem worldwide, is characterized by an increase in body weight that results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and leads to several diseases, including metabolic syndrome, diabetes mellitus, cardiovascular, fatty liver diseases, and cancer. Growing evidence allows us to understand the critical role of adipose tissue in controlling the physic-pathological mechanisms of obesity and related comorbidities. Recently, adipose tissue, especially in the visceral compartment, has been considered not only as a simple energy depository tissue, but also as an active endocrine organ releasing a variety of biologically active molecules known as adipocytokines or adipokines. Based on the complex interplay between adipokines, obesity is also characterized by chronic low grade inflammation with permanently increased oxidative stress (OS). Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to the development of obesity-related complications. The aim of this review is to summarize what is known in the relationship between OS in obesity and obesity-related diseases.

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Section: Oxidative Stress and Obesitymentioning

confidence: 99%

Oxidative Stress in Obesity: A Critical Component in Human Diseases

Marseglia

Manti

Nicotera

et al. 2014

IJMS

Self Cite

760

512

View full text Add to dashboard Cite

show abstract

“…16,35 Literature data are still controversial in pediatric populations, especially in term and preterm newborns. Serum visfatin concentrations seems significantly related to birth weight, 8 although visfatin levels appear to be influenced by other maternal 36 and neonatal factors including IUGR, 9 smoking mothers 14 and sepsis. 16 To our knowledge no data are available on the correlation between visfatin levels and OS potentially related to high oxygen concentration administered during resuscitation at birth.…”

Section: Discussionmentioning

confidence: 99%

Visfatin: New marker of oxidative stress in preterm newborns

Marseglia

Márta

Aversa

et al. 2015

Int J Immunopathol Pharmacol

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Preterm newborns are challenged by excessive oxidative injury, resulting from several perinatal stimuli, such as intrauterine infections, resuscitation in delivery room, mechanical ventilation, and postnatal complications, in the presence of immature antioxidant capacities.Free radicals (FRs) are molecular species with an unpaired electron in the outer shell which renders them highly reactive and unstable. 1 FRs containing oxygen may be termed a reactive oxygen species (ROS). Abstract Background: Oxidative stress is involved in several neonatal conditions characterized by an upregulation in the production of oxidative or nitrative free radicals and a concomitant decrease in the availability of antioxidant species. Oxygen, which is obviously vital to survival, can be highly damaging to neonatal tissue which is known to be poorly equipped to neutralize toxic derivatives. Thus, exposure of the newborn infant to high oxygen concentrations during resuscitation at birth increases oxidative damage. Visfatin is an adipocytokine involved in oxidative stress and an important mediator of inflammation that induces dose-dependent production of both pro-inflammatory and anti-inflammatory cytokines. To our knowledge, the diagnostic value of visfatin as a marker of oxidative stress in preterm newborns has not been investigated. Objective: The aim of this study was to evaluate visfatin levels in preterm neonates resuscitated with different concentrations of oxygen in the delivery room. Patients: Fifty-two preterm newborns with gestational age less than 32 weeks, resuscitated randomly with different oxygen concentrations (40%, 60%, or 100%) were enrolled at the University Hospital of Messina, over a 12-month period to evaluate serum visfatin levels at T0 (within 1 h after birth), T24 h, T72 h, and T168 h of life. Results: At T72 h and T168 h, higher serum visfatin values in the high-oxygen group compared to the low-and mildoxygen subjects (P = 0.002 and P <0.001, respectively) were noted. Conclusion:The results of this study suggest that visfatin could be a new marker of oxidative stress in preterm newborns.

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“…However, the exact mechanism linking obesity with IUGR is still unknown 76 . In the cases of IUGR, serum visfatin levels are also elevated in mothers 50,51,95 and neonates 52 . Because IUGR can be associated with hampered IIS in the foetus and visfatin itself can promote IR, 96,97 a direct correlation between IUGR and visfatin‐related IR cannot be excluded (Figure 2).…”

Section: Visfatin and Obesity‐related Pregnancy Complicationsmentioning

confidence: 99%

Can adipokine visfatin be a novel marker of pregnancy‐related disorders in women with obesity?

et al. 2020

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Overweight and obesity have become a dangerous disease requiring multiple interventions, treatment and preventions. In women of reproductive age, obesity is one of the most common medical conditions. Among others, obese state is characterized by low-grade systemic inflammation and enhanced oxidative stress. Increased maternal body mass index might amplify inflammation and reactive oxygen species production, which is associated with unfavourable clinical outcomes that affect both mother and child. Intrauterine growth retardation, preeclampsia, or gestational diabetes mellitus are examples of the hampered maternal and foetoplacental unit interactions. Visfatin is the obesity-related adipokine produced mainly by the visceral adipose tissue.Visfatin affects glucose homeostasis, as well as the regulation of genes related to oxidative stress and inflammatory response. Here, we review visfatin interactions in pregnancy-related disorders linked to obesity. We highlight the possible predictive and prognostic value of visfatin in diagnostic strategies on gravidas with obesity. K E Y W O R D S obesity, pregnancy, visfatin

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The Role of Visfatin in Pregnancy, Complications and Procreation

Cited by 10 publications

References 71 publications

Oxidative Stress in Obesity: A Critical Component in Human Diseases

Oxidative Stress in Obesity: A Critical Component in Human Diseases

Visfatin: New marker of oxidative stress in preterm newborns

Can adipokine visfatin be a novel marker of pregnancy‐related disorders in women with obesity?

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