The Relationship between Serum Selenium Levels and Lipid Profiles in Adult Women

Lee, Ok-Hee; Moon, Jongwha; Chung, Yong-Sam

doi:10.3177/jnsv.49.397

Cited by 47 publications

(28 citation statements)

References 34 publications

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“…Indeed, previous cross-sectional associations between lipid profile and selenium largely depend on studied populations [40][41][42]. In the general population, positive association between HDL and selenium have been reported in agreement with our results [10,11], but…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Fibrates but not statins increase plasma selenium in dyslipidemic aged patients – The EVA study

Arnaud

Akbaraly

Hininger‐Favier

et al. 2009

Journal of Trace Elements in Medicine and Biology

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Section: Discussionsupporting

confidence: 83%

“…Among the confounding factors, age [41], sex [16,17], lipid concentrations [42] have been evidenced.…”

Section: Discussionmentioning

confidence: 99%

Fibrates but not statins increase plasma selenium in dyslipidemic aged patients – The EVA study

Arnaud

Akbaraly

Hininger‐Favier

et al. 2009

Journal of Trace Elements in Medicine and Biology

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“…An association of selenium status with blood lipids was reported previously (Navarro-Alarcon et al, 1999;Lee et al, 2003). Gonzalez et al (2004) observed a correlation between selenium status and plasma homocysteine.…”

Section: Discussionsupporting

confidence: 51%

Selenium and antioxidant vitamin status of elderly German women

et al. 2005

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Objective: Low antioxidant intake and status have been shown to be associated with an elevated risk for various diseases. Data on the status of antioxidant vitamins, selenium and coenzyme Q10 of younger female seniors are scarce. The aim of this study was to assess the status of these antioxidants, as well as influencing factors such as dietary intake, anthropometric data and educational level in female seniors (60-70 years) in Germany. Design: Dietary intake of alpha-tocopherol, beta-carotene and ascorbic acid was determined by a 3-day diet record. Serum concentrations of alpha-tocopherol, beta-carotene, ascorbic acid, selenium and coenzyme Q10 were measured. Anthropometric measures, socioeconomic and educational status were assessed. Setting: In total, 178 elderly women without severe diseases in the region of Hannover, Germany, were included in the study. The mean (7s.d.) age and BMI of the women was 63.2 (2.73) years and 25.6 (3.77) kg/m 2 , respectively. The study participants were generally better educated than the overall German female population. Results: Dietary intake of the ascorbic acid and alpha-tocopherol was below RDA in six and 75% of the women, respectively. In comparison to estimated desirable serum concentrations of alpha-tocopherol, ascorbic acid, beta-carotene and selenium, lower concentrations were found in 23, 1, 6, and 39% of the women, respectively. Ascorbic acid (r ¼ 0.205, P ¼ 0.009) and betacarotene (r ¼ 0.173, P ¼ 0.025) intake were significantly associated with serum concentrations. Beta-carotene concentrations were influenced by the type of diet, BMI, and school education (R 2 ¼ 0.128, Po0.001). Serum selenium was positively associated with alcohol intake (r ¼ 0.229, P ¼ 0.003). Neither employment nor vocational training was predictive for the serum concentrations of antioxidant vitamins, selenium or coenzyme Q10. Conclusions: Poor status of selenium and alpha-tocopherol is highly prevalent even among younger, well-educated female seniors, whereas ascorbic acid and beta-carotene status seems sufficient in most women.

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“…Several studies related hypercholesterolemia with Se deficiency (Huang et al 2002;Lee et al 2003). Vijaya et al (2000) reported that Se deficiency is associated with cardiomyopathy resulting in congestive heart failure.…”

Section: Introductionmentioning

confidence: 98%

Hypercholesterolemia and LDL receptor mRNA expression: modulation by selenium supplementation

Dhingra¹,

Bansal²

2006

Biometals

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Selenium (Se) status has been associated with cardiovascular disorders. Present study was aimed to elucidate the protective role of Se supplementation on LDL receptor (LDL-R) activity as well as mRNA expression during experimental hypercholesterolemia in SD male rats. Animals were fed 0.2 and 1 ppm Se supplemented control diet as well as 2% cholesterol supplemented diet for 3 months. LDL-R activity was measured in-vivo by injecting radiolabeled LDL to rats and decrease in counts per minute with time was taken as a measure of LDL clearance and in turn LDL-R activity. LDL-R mRNA expression was studied by RT-PCR. LDL-R activity and mRNA expression decreased significantly on 2% cholesterol supplemented diet feeding. On 1 ppm Se supplementation LDL-R activity as well as mRNA expression increased significantly. Present results demonstrate that Se supplementation upto 1 ppm is responsible for up regulation of LDL-R activity as well as mRNA expression, during hypercholesterolemia. These findings highlight the therapeutic potential of Se supplementation in lipid metabolism.

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The Relationship between Serum Selenium Levels and Lipid Profiles in Adult Women

Cited by 47 publications

References 34 publications

Fibrates but not statins increase plasma selenium in dyslipidemic aged patients – The EVA study

Fibrates but not statins increase plasma selenium in dyslipidemic aged patients – The EVA study

Selenium and antioxidant vitamin status of elderly German women

Hypercholesterolemia and LDL receptor mRNA expression: modulation by selenium supplementation

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