The Relationship Between Serum Lipids and Periodontitis in Elderly Non‐Smokers

Izumi, Aki; Yoshihara, Akihiro; Hirotomi, Toshinobu; Miyazaki, Hideo

doi:10.1902/jop.2009.080584

Cited by 17 publications

(21 citation statements)

References 41 publications

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“…Similar results were reported by previous studies 5,27 . This finding is not consistent with previous studies where an ultra sensitive methodology was employed [4][5][6]23 or when other methods were used 3,29,30 .…”

Section: Discussionsupporting

confidence: 93%

“…Consistent with our findings, previous studies have also detected a negative association between clinical parameters of periodontal disease and HDL-c 5,15,22 . The agreement between ours, and previous findings, can be based on the methodological similarities including mean age of the participants, the methodology applied measuring HDL-c levels and the full [23][24][25][26][27] . A possible explanation for these conflicting findings include: the low number of subjects enrolled in some studies 23,24 ; a wide age range of the participants 3,[24][25][26] ; mean age of participants 25 and the lack of adjustment for confounders, such as dental plaque 4,[23][24][25][26] and smoking [24][25][26] .…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Association between markers of cardiovascular risk and clinical parameters of periodontitis

Eduardo

Domingues

Vettore

et al. 2013

Rev. odontol. UNESP

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ResumoIntrodução: A doença periodontal é uma resposta inflamatória a bactérias que residem no tecido gengival podendo apresentar repercussão sistêmica. Objetivo: O objetivo deste estudo foi conhecer a relação entre a periodontite e marcadores do risco cardiovascular. Material e método: Noventa pacientes selecionados foram divididos em dois grupos de acordo com os níveis de profundidade de sondagem (PS) e nível clínico de inserção (NCI). Grupo controle, n =45 (< 4 sítios com PS ≥ 4.0 mm e NCI ≥3.0 mm) e grupo casos, n =45 (≥30% dos sítios com PS ≥ 4.0 mm e NCI ≥ 3.0 mm). Todos os indivíduos foram submetidos a dosagens plasmáticas de Proteína C reativa de alta sensibilidade, HDL-c e Lipoproteína de baixa densidade eletronegativa (LDL -). Dados do histórico médico e nível socioeconômico foram também coletados. Resultado: Os níveis plasmáticos de HDL-c foram maiores nos indivíduos com doença periodontal (p = 0,016) e inversamente associados com o número de sítios periodontais com OS ≥ 3 mm (rho= -0.325) e números de sítio com OS ≥ 3 mm e NCI ≥ 3 mm (rho= -0.216). NCI ≥ 3 mm. Estas associações permaneceram após ajuste para biolfilme e uso de cigarro usando análise de covariância univariada (p < 0.05). O odds ratio ajustado entre a doença periodontal e os níveis de HDL-c foi 0.94 (CI95% 0.88-0.99) após ajuste para idade, fumo e biofilme. Os demais marcadores do risco vascular não foram relacionados com a doença periodontal. Conclusão: Os parâmetros clínicos da periodontite foram inversamente associados com as concentrações de HDL-c.Descritores: Doenças periodontais; HDL-c; doença cardiovascular coronariana; risco cardiovascular. AbstractIntroduction: Periodontal disease is an inflammatory response to bacteria that reside in the gum tissue and can have systemic repercussion. Objective: The aim of this study was to assess the relationship between periodontitis and markers of cardiovascular risk. Material and method: Ninety selected patients were assigned into two groups in accordance with their levels of probing pocket depth (PPD) and Clinical Attachment Level (CAL): control group, n= 45 (< 4 sites with PPD ≥ 4.0 mm and CAL ≥ 3.0 mm) and case group, n= 45 (≥ 30% of sites with PPD ≥ 4.0 mm and CAL ≥3.0 mm). Plasma concentrations of C-reactive protein, high sensitive CRP, high-density lipoproteins (HDL-c) and electronegative low density lipoproteins (LDL) were assessed in all participants. Data from medical history and socioeconomic level were also collected from patients. Result: Plasma levels of HDL-c were lower in subjects with periodontal disease (p = 0.016) and were inversely associated with the number of sites with PPD ≥ 3 mm (rho= -0.325) and number of sites with PPD ≥ 3 mm and CAL ≥ 3 mm (rho= -0.216). These associations remained significant after adjustments for dental plaque and smoking using Univariate Analysis of Covariance (p < 0.05). Adjusted odds ratio between periodontal disease and levels of HDL-c was 0.94 (CI95% 0.88-0.99) after adjusting for age, smoking and dental plaque. Other investigated markers of ...

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 79%

Association between markers of cardiovascular risk and clinical parameters of periodontitis

Eduardo

Domingues

Vettore

et al. 2013

Rev. odontol. UNESP

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“…22 Associations between periodontal diseases and serum lipid levels was found in several studies. 23,24 On the hand, other studies found no relationship. 25,26 Review from Griffiths and Barbour suggests that periodontal diseases shifts the lipoprotein profile to be more proatherogenic.…”

Section: Introductionmentioning

confidence: 89%

The Association between Periodontal Conditions and Serum Lipids among Elderly Participants in Gadjah Mada Medical Centre, Yogyakarta

Widita¹,

Hanindriyo²,

Widyaningrum³

et al. 2017

J Dent Indones

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Prevention of cardiovascular diseases by controlling risk factors at an early stage is very important. Objective: To determine the relationship between periodontal conditions with serum lipids among the elderly. Methods: Total of 78 participants (56 males and 32 females) who were in the age range of 60-76 years were selected for the current study. A logistic regression analysis was used to evaluate the association between periodontal conditions and serum lipid profile. Periodontal conditions was recorded as the maximum score of pocket depth (PD) and loss of attachment (LoA) score which presented in the participants, while levels of total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and triglycerides (TG) were measured for the serum lipids profile. Age, gender, BMI, high blood pressure, pattern of dental visit, hypertension and cholesterol medication, number of teeth, PD, and LoA were included in the model as independent variable. TC, HDL, LDL, and TG were used as dependent variables. Results: According to the results of the logistic regression analysis, loss of attachment >6 mm was associated with TC (p<0.01;, while PD had no association with serum lipids (p>0.05). Conclusion: This study indicates that subjects with greater loss of attachment significantly associated with higher levels of serum TC and LDL. This may suggest that elderly people with greater loss of attachment are potentially at risk of having serum lipid impairment.

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“…Serum albumin, IgG and total cholesterol levels were determined by colorimetry method, immunoassay turbidimetric method and enzyme method, respectively, at a commercial laboratory ( † ). Serum levels of IgG and total cholesterol are immunological or nutrient-related index, which were associated with dental caries or periodontal disease from our past investigation (16,22). Serum albumin concentrations ≤4Á0 g dL À1 were defined as low levels according to previous reports (1,23).…”

Section: Methodsmentioning

confidence: 99%

Serum albumin levels and 10‐year tooth loss in a 70‐year‐old population

Yoshihara

Iwasaki

Ogawa

et al. 2013

J of Oral Rehabilitation

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Serum albumin levels are a practical marker of general health status in the elderly and have been used to determine the severity of underlying diseases and the risk for death. This longitudinal study evaluated the relationship between serum albumin concentrations and tooth loss over 10 years in elderly subjects, after controlling for confounding factors. A sample of 554 dentate subjects among enrolled subjects (n = 600) was involved in this planned longitudinal study with follow-up examinations after 5 and 10 years. At the 5-year follow-up, 373 (67·3%), subjects were available for re-examination. In addition, 331 (59·7%) were available at the 10-year follow-up. Multiple Poisson regression analysis was conducted to evaluate the relationship between the number of missing teeth over 5 or 10 years and serum albumin levels at baseline after adjusting for 10 variables: gender, serum markers levels at baseline, dental status, smoking habits and educational years and oral health behaviour. The number of missing teeth over 5 or 10 years was significantly negatively associated with serum albumin levels at baseline [incidence rate ratios (IRR) = 0·373, P < 0·0001 for 5 years; IRR = 0·570, P < 0·0001 for 10 years]. We conclude that elderly subjects with hypoalbuminemia are at high risk for 5- and 10-year tooth loss.

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The Relationship Between Serum Lipids and Periodontitis in Elderly Non‐Smokers

Abstract: Higher TC is associated with a lower prevalence of periodontitis in non-smoking elderly patients.

Cited by 17 publications

References 41 publications

Association between markers of cardiovascular risk and clinical parameters of periodontitis

Association between markers of cardiovascular risk and clinical parameters of periodontitis

The Association between Periodontal Conditions and Serum Lipids among Elderly Participants in Gadjah Mada Medical Centre, Yogyakarta

Serum albumin levels and 10‐year tooth loss in a 70‐year‐old population

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