The Relationship Between Serum Level of Malondialdehyde and Progression of Colorectal Cancer

Abstract

SUMMARY – The purpose of the study was to assess the level of serum malondialdehyde (MDA) concentration and its association with the stage and histopathologic sizes of colorectal cancer (CRC). One hundred and two patients having undergone surgical treatment of CRC between January 2014 and December 2015 were included in this cross-sectional study. The patients were divided into four groups (stage I-IV) according to the TNM classification. Control group included 30 subjects with no signs of malignancy and inflammatory diseases. In each patient, preoperative blood samples were obtained for determination of MDA concentration by ELISA immunoassay. Serum levels of MDA were progressively increased in patients with CRC, reaching the highest value in the fourth stage of CRC. Serum concentrations of MDA were significantly higher in pT4 group as compared with pT3 and pT2 groups of CRC patients (p<0.01). Significantly higher levels of MDA were found in the N1 and N2 groups of CRC patients as compared with N0 group, as well as in patients with metastatic disease as compared with those without metastasis (p<0.001). In conclusion, the progression of CRC is associated with a significant increase in serum MDA levels.

Selected Oxidative Stress Markers in Colorectal Cancer Patients in Relation to Primary Tumor Location—A Preliminary Research

“…Rašić et al noted similar results. Their study demonstrated statistically significant differences in serum MDA levels and stage II and III of the disease (p < 0.01) [20]. However, Wu et al observed no statistically significant differences in TOS and TAS levels and the clinical stage of the cancer (p < 0.05) [15].…”

Pro-Oxidant Enzymes, Redox Balance and Oxidative Damage to Proteins, Lipids and DNA in Colorectal Cancer Tissue. Is Oxidative Stress Dependent on Tumour Budding and Inflammatory Infiltration?

“…Therefore, lipid peroxidation is enhanced with the increase in the depth of tumour invasion. It is suggested that MDA can act as a carcinogenic agent and promoter of CRC development/progression [ 53 ]. This is also confirmed by higher MDA level in patients with high-grade tumour budding as well as in subjects with lymph node metastases.…”

Oxidative stress and radioiodine treatment of differentiated thyroid cancer

“…Nevertheless, ROS-related tissue destruction can be observed by the final products of lipid peroxidation, such as MDA. Therefore, MDA’s diagnostic utility has been suggested in many diseases, such as colorectal cancer 42 , spontaneous intracerebral hemorrhage 43 , depression 44 , 45 , and alcoholic hepatitis diagnosis 46 . Furthermore, MDA has also been demonstrated to be a significant independent positive predictor of the patient depth of tumor invasion and an independent positive predictor of lymph node infiltration by cancer tissue, as well as the occurrence of metastasis 42 .…”

“…Therefore, MDA’s diagnostic utility has been suggested in many diseases, such as colorectal cancer 42 , spontaneous intracerebral hemorrhage 43 , depression 44 , 45 , and alcoholic hepatitis diagnosis 46 . Furthermore, MDA has also been demonstrated to be a significant independent positive predictor of the patient depth of tumor invasion and an independent positive predictor of lymph node infiltration by cancer tissue, as well as the occurrence of metastasis 42 . However, when considering common MDA measurements in clinical practice, the need for full validation data should be considered.…”