Oxidative stress and radioiodine treatment of differentiated thyroid cancer

Buczyńska, Angelika; Sidorkiewicz, Iwona; Rogucki, Mariusz; Siewko, Katarzyna; Adamska, Agnieszka; Kościuszko, Maria; Maliszewska, Katarzyna; Kozłowska, Gabryela; Szumowski, Piotr; Myśliwiec, Janusz; Dzięcioł, J; Krętowski, Adam; Popławska-Kita, Anna

doi:10.1038/s41598-021-96637-5

Cited by 22 publications

(18 citation statements)

References 52 publications

(62 reference statements)

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“…antral follicles). Increased oxidative stress levels ( 30 ) may cause severe oocyte damages, which may lead to an impairment of their fertilization capacity, probably caused by increased oxidative stress levels through apoptosis and DNA damage upregulations. The decreased developmental potential of oocytes from poorly vascularized follicles has also been attributed to low intrafollicular oxygenation.…”

Section: Discussionmentioning

confidence: 99%

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Adamska

Tomczuk-Bobik

Popławska-Kita

et al. 2021

Endocrine Connections

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Treatment with radioactive iodine (RAI) in women with differentiated thyroid cancer is associated with decreased serum concentrations of anti-Müllerian hormone (AMH); however, other markers have not been investigated. Therefore, this study aimed to evaluate the effect of RAI on antral follicle count (AFC) and the serum concentration of inhibin B, follicle-stimulating hormone (FSH), and AMH in women with papillary thyroid cancer (PTC) treated with RAI. We examined 25 women at a median age of 33 years treated with a single dose of RAI. We divided the participants into women over (n = 11) and under 35 years of age (n = 14). Serum concentrations of inhibin B, FSH, AMH, and AFC were assessed at baseline and one year after RAI treatment. We found decreased AFC (p = 0.03), serum levels of AMH (p < 0.01), inhibin B (p = 0.03), but not FSH (p = 0.23), one year after RAI treatment in comparison to baseline in the whole group. When we compared serum levels of AMH in younger vs. older women separately, we observed a significant reduction of this hormone’s serum level after RAI treatment in both groups (p < 0.01; p = 0.04, respectively). We concluded that RAI treatment significantly impacts the functional ovarian reserve in premenopausal women with PTC.

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Section: Discussionmentioning

confidence: 99%

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Adamska

Tomczuk-Bobik

Popławska-Kita

et al. 2021

Endocrine Connections

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“…Radioactive iodine therapy (RAI) is the standard treatment for differentiated thyroid cancer (DTC). The increased oxidative stress, reflected by malondialdehyde (MDA) measurements, further enhanced by RAI in DTC patients may have important implications for future health complications [ 169 , 170 ]. Despite the beneficial therapeutic effect of RAI intervention, exposure to radiation can lead to several oxidative alterations, especially in the metabolism of reproductive system tissue [ 7 , 171 ].…”

Section: Can Metformin Intervention Be Considered As Adjuvant Anti-ca...mentioning

confidence: 99%

Metformin Intervention—A Panacea for Cancer Treatment?

Buczyńska

Sidorkiewicz

Krętowski

et al. 2022

Cancers

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The molecular mechanism of action and the individual influence of various metabolic pathways related to metformin intervention are under current investigation. The available data suggest that metformin provides many advantages, exhibiting anti-inflammatory, anti-cancer, hepatoprotective, cardioprotective, otoprotective, radioprotective, and radio-sensitizing properties depending on cellular context. This literature review was undertaken to provide novel evidence concerning metformin intervention, with a particular emphasis on cancer treatment and prevention. Undoubtedly, the pleiotropic actions associated with metformin include inhibiting inflammatory processes, increasing antioxidant capacity, and improving glycemic and lipid metabolism. Consequently, these characteristics make metformin an attractive medicament to translate to human trials, the promising results of which were also summarized in this review.

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“…The sources of ROS in tumors may be suggested as novel targets for antitumorigenic therapies. According to recent studies, oxidative reactions have interdependence with thyroid cancer occurrence [ 20 , 21 ]. It might be assumed as an identification marker that separates thyroid cancer from benign thyroid tumors.…”

Section: Oxidative Stress and Thyroid Cancermentioning

confidence: 99%

The Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer

Heydarzadeh

Kia

Zarkesh

et al. 2022

Oxidative Medicine and Cellular Longevity

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The most serious hallmark step of carcinogenesis is oxidative stress, which induces cell DNA damage. Although in normal conditions ROS are important second messengers, in pathological conditions such as cancer, due to imbalanced redox enzyme expression, oxidative stress can occur. Recent studies with firmly established evidence suggest an interdependence between oxidative stress and thyroid cancer based on thyroid hormone synthesis. Indeed, a reduced antioxidant defense system might play a part in several steps of progression in thyroid cancer. Based on studies that have been conducted previously, future drug designs for targeting enzymatic ROS sources, as a single agent or in combination, have to be tested. Polyphenols represent the potential for modulating biological events in thyroid cancer, including antioxidative activity. Targeting enzymatic ROS sources, without affecting the physiological redox state, might be an important purpose. As regards the underlying chemopreventive mechanisms of natural compounds that have been discussed in other cancer models, the confirmation of the influence of polyphenols on thyroid cancer is inconclusive and rarely available. Therefore, there is a need for further scientific investigations into the features of the antioxidative effects of polyphenols on thyroid cancer. The current review illustrates the association between some polyphenols and the key enzymes that take place in oxidation reactions in developing thyroid cancer cells. This review gives the main points of the enzymatic ROS sources act and redox signaling in normal physiological or pathological contexts and supplies a survey of the currently available modulators of TPO, LOX, NOX, DUOX, Nrf2, and LPO derived from polyphenols.

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Oxidative stress and radioiodine treatment of differentiated thyroid cancer

Cited by 22 publications

References 52 publications

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Metformin Intervention—A Panacea for Cancer Treatment?

The Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer

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