The relationship between serology of hepatitis E virus with liver and kidney function in kidney transplant patients

Zeraati, Abbas Ali; Nazemian, Fatemeh; Takalloo, Ladan; Sahebkar, Amirhossein; Heidari, Elahe; Yaghoubi, Mohammad Ali

doi:10.17179/excli2016-232

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Additionally, as one of the debilitating diseases with a high mortality rate, the incidence of CKD is increasing worldwide ( 1 , 3 ). The term End-Stage Renal Disease (ESRD) is an irreversible impairment of kidney function that leads to permanently dependent on alternative therapies such as hemodialysis, peritoneal dialysis, and renal transplantation ( 4 – 6 ). The prevalence of ESRD in Iran is estimated at about 357 per million with an annual incidence of about 57 per million ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis

Ghelichi-Ghojogh¹,

Ghaem²,

Mohammadizadeh³

et al. 2021

ijph

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Background: End-Stage Renal Disease (ESRD) is an irreversible impairment of kidney function that leads to permanently dependent on alternative therapies such as hemodialysis, peritoneal dialysis, and renal transplantation. This study aimed to systematically investigate the survival rate of patients with renal transplantation, graft, and its related factors in Iran. Methods: This systematic review and meta-analysis drew on articles indexed in six international and one internal databases (Medline/PubMed, ProQuest, Scopus, Embase, SID, and Web of knowledge) until Nov 2020. The reporting of the present study was performed in terms of PRISMA statement. All analyzes were performed using the STATA software. Results: Overall, 367 titles from 6 databases were evaluated of which 86 articles met the inclusion criteria. According to the random model, the graft survival rate at one, three, five, and 10 years were 92.48%, 85.08%, 79.96% and 68.15% respectively. Additionally, the patient survival rates at one, three, five, and 10 years were 91.27%, 86.46%, 81.17% and 78.15% respectively. There was a significant relationship between the age recipient and three-year graft survival rate (P=0.021). Additionally, there was an inverse and significant relationship between the donor age and 10-year patient survival rate (P=0.011). Conclusion: The patient and graft survival in transplanted kidney patients is comparable with most developed countries.

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Section: Introductionmentioning

confidence: 99%

Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis

Ghelichi-Ghojogh¹,

Ghaem²,

Mohammadizadeh³

et al. 2021

ijph

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High prevalence of anti-HEV antibodies among patients with immunosuppression and hepatic disorders in eastern Poland

et al. 2021

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Introduction: The incidence of hepatitis E virus (HEV) infections in Poland is largely unknown. This study aimed to describe seroprevalence of markers of HEV infection among patients with immunodeficiency of diverse etiology and patients with advanced chronic liver diseases. Material and methods: Four hundred fifty patients were enrolled; among them, 180 persons were solid organ transplant recipients, 90 patients were HIV-infected and 180 persons had confirmed liver cirrhosis of different etiology. Serum anti-HEV-IgG, IgM antibodies and HEV-antigen were detected by ELISA (Wantai, China). Results: In the group of transplant recipients, serum anti-HEV-IgG antibodies were detected in 40.6%, IgM in 1.1% and HEV-Ag in 2.8% of subjects. In the HIV-infected population 37.7% had anti-HEV-IgG, 1.1% had anti-HEV-IgM and none had HEV-Ag. Among patients with advanced chronic liver diseases the highest prevalence of anti-HEV-IgG was recorded in alcohol-related liver cirrhosis (52.1%) (p = 0.049). In the population of all liver cirrhotics anti-HEV-IgG seroprevalence was 48.3%, anti-HEV-IgM seroprevalence was 5.0% and HEV-Ag seroprevalence was 1.7%. Older age and male gender were significant risk factors associated with increased anti-HEV-IgG prevalence, p = 0.0004 and p = 0.02, respectively. Conclusions: In this large cohort a high seroprevalence of anti-HEV-IgG was detected in comparison to other European countries, with the highest rates in patients with alcoholic liver disease and in transplant recipients.

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Hepatitis E Virus Infection Among Iranian Patients with Beta-Thalassemia

Bineshian

Dalvand

Hosseini

et al. 2020

Middle East J Rehabil Health Stud

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Background: The main transmission route of hepatitis E is fecal-oral by contaminated water and food. Besides, it can be transmitted through infected blood of persons with subclinical infection. Objectives: The current study aimed to estimate the prevalence of hepatitis E virus infection as an emerging virus among thalassemic patients. Methods: In this cross-sectional study, 110 thalassemia patients who were living in Tehran Province were selected. All serum samples were assessed for the presence of total anti-HEV antibodies (IgG and IgM). After RNA extraction from sera, cDNA was synthesized, and RT-PCR was used to determine the HEV-RNA. Results: The results of the ELISA test showed that 4.5% of thalassemia patients were positive for anti-HEV Ab. Also, the prevalence of HEV-RNA was 0.0% among thalassemia patients. Conclusions: The frequency of HEV-RNA among thalassemia patients was 0.0%. Therefore, the risk of HEV infection via blood transmission among thalassemia patients is low in Iran. However, to prevent the possibility of HEV transmission, precautionary measures should be considered in blood recipients.

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The relationship between serology of hepatitis E virus with liver and kidney function in kidney transplant patients

Cited by 3 publications

References 37 publications

Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis

Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis

High prevalence of anti-HEV antibodies among patients with immunosuppression and hepatic disorders in eastern Poland

Hepatitis E Virus Infection Among Iranian Patients with Beta-Thalassemia

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