Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis

Ghelichi-Ghojogh, Mousa; Ghaem, Haleh; Mohammadizadeh, Fateme; Vali, Mouhebat; Ahmed, Faisal; Hassanipour, Soheil; Nikbakht, Hossein-Ali; Rezaei, Fatemeh; Fararouei, Mohammad

doi:10.18502/ijph.v50i8.6801

Cited by 7 publications

(13 citation statements)

References 39 publications

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“…4 Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran. 5 Department of Health Education and Health Promotion, School of Health, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. 6 Urmia Health center, Urmia University of Medical Sciences, Urmia, Iran.…”

Section: Supplementary Informationmentioning

confidence: 99%

“…The prevalence of ESRD (End Stage Renal Disease) is currently increasing as a global health problem in both developed and developing countries [1][2][3]. Chronic kidney disease (CKD) is a disease associated with irreversible kidney damage that can progress to ESRD (end-stage renal disease) [4][5][6][7][8]. ESRD is a destructive disorder that is associated with extreme mortality and cardiovascular complications, and certain problems such as developmental and psychosocial disorders occur in children, all of which severely affect quality of life [9,10].…”

Section: Introductionmentioning

confidence: 99%

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The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis

et al. 2022

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Background This study is a systematic review and meta-analysis on published studies about the Global Survival Rate of Graft and Patients in the Kidney Transplantation of children. Methods Studies that investigated the survival rate of kidney transplants published until the 30th of December 2020 were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane. The extracted data were entered into the Excel software and STATA 16.0. The search identified 6007 study references. From the total, we excluded 1348 duplicates, 3688 reference titles and abstracts that were deemed irrelevant, and 846 references that were not original articles (i.e., letter, commentary, review) or did not meet the inclusion criteria. As such, 89 studies involving 12,330 participants were included in this meta-analysis. Results In this study 1, 3, 5, 7 and 10-year survival rates of graft were estimated to be 92, 83, 74.40, 67.10, and 63.50%, respectively. Also, 1, 3, 5, 7 and 10-year survival rates of patients were estimated to be 99.60, 97.30, 95.20, 74.60, and 97.90%, respectively. Conclusions The findings suggest differences in graft and patient survival among children with kidney transplants. Although differences in ethnic origin, incompatibility with deceased donor kidneys, and types of kidney disease are unavoidable, interventions to improve preventive and living-donor transplantation are particularly needed in minority groups. In addition, more research is needed to establish and address the contribution of medical and sociocultural barriers to preferential treatment of these groups.

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Section: Supplementary Informationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis

et al. 2022

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“…1,2 Furthermore, with the advent of modern immunosuppressive drugs, the graft survival rate for kidney transplantation is over 90% at one year. 3,4 However, availability of donor organs continues to be a major barrier to successful transplantation: in 2020, 4879 people died waiting for an available kidney and 37 408 patients were added to the waitlist. 4,5 Xenotransplantation, the transplantation of animal organs into humans, is being developed as a potential solution to the organ shortage.…”

Section: Introductionmentioning

confidence: 99%

“…Kidney transplantation offers curative treatment and long‐term benefit over dialysis for patients suffering from end‐stage renal disease (ESRD) 1,2 . Furthermore, with the advent of modern immunosuppressive drugs, the graft survival rate for kidney transplantation is over 90% at one year 3,4 . However, availability of donor organs continues to be a major barrier to successful transplantation: in 2020, 4879 people died waiting for an available kidney and 37 408 patients were added to the waitlist 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Attitudes of patients with renal disease on xenotransplantation: A systematic review

DeLaura

Anwar

Ladowski

et al. 2023

Xenotransplantation

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Background Recent years have seen major advancements in xenotransplantation: the first pig‐to‐human heart transplant, the development of a brain‐dead recipient model for kidney xenotransplantation, and the registration of the first xenokidney clinical trial. The attitudes of patients with kidney disease or transplants on xenotransplantation and an assessment of their reservations and considerations regarding the technology are crucial to successful clinical translation and eventual widespread implementation. Methods This systematic review was registered through PROSPERO (CRD42022344581) prior to initiation of the study and reported using the Preferred Reporting Items for Systematic Review and Meta‐Analyses (PRISMA) guidelines. We included studies that evaluated attitudes towards and willingness to undergo xenotransplantation in patients with end‐stage renal disease (ESRD), including those who had already undergone transplantation. MEDLINE (via Ovid), Embase (via Elsevier), and Web of Science (via Clarivate) were searched from database inception to July 15, 2022 by an experienced medical librarian for studies on xenotransplantation and attitudes. Abstracts and full text were screened using Covidence software and data items regarding study methodology, patient demographics, and attitudes regarding xenotransplantation were extracted using Microsoft Excel. Risk of bias assessments were performed using the Critical Appraisal Skills Programmed and National Institute of Health study quality assessment tools. Results Of 1992 studies identified, 14 studies met the inclusion criteria. These studies were conducted across eight countries, four in the United States, for a total of 3114 patients on the kidney waitlist or with a kidney transplant. All patients were over 17 years old and 58% were male. Acceptance of a xenotransplant was assessed using surveys in 12 studies. Sixty‐three percent (n = 1354) of kidney patients reported that they would accept a xenotransplant with function comparable to that of an allotransplant. Acceptance of xenografts with inferior function to allografts (15%) or as bridge organs (35%) to allotransplantation was lower. Specific concerns expressed by patients included graft function, infection, social stigma, and animal rights. Subgroup analyses showed higher acceptance in already transplanted compared to waitlist patients and white compared to Black Americans. Conclusion An understanding of patient attitudes and reservations is key to the successful execution of the first xenotransplantation clinical trials. This study compiles important factors to consider, such as patient concerns, attitudes regarding practical clinical scenarios for the use of xenotransplantation, and the impact of demographic factors on acceptance of this emerging technology.

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“…Chronic Kidney Disease (CKD) involves a range of different pathophysiological processes associated with abnormal renal function and progressive decline in glomerular filtration rate ( 1 , 2 ). The end stage renal disease is irreversible impairment of renal function, to the extent that the patient becomes permanently dependent on alternative therapies, especially in children ( 1 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Graft and Patient Survival Rate among Iranian Pediatric Recipients of Kidney Transplantation: A Systematic Review and Meta-Analysis

Shajari¹,

Ashrafi²,

Shajari³

et al. 2022

ijph

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Background: The End Stage Renal Disease (ESRD) is irreversible impairment of renal function, to the extent that the patient becomes permanently dependent on alternative therapies, especially in children. We aimed to evaluate the graft and patient survival rate among iranian pediatric recipients of kidney transplantation through a systematic review and meta-analysis. Methods: National (SID, MagIran, IranMedex, IranDoc) and international (Cochrane, Embase, ScienceDirect, Scopus, PubMed, and Web of Science) databases of, were searched to find studies published electronically from 1985 until Nov 2019. Heterogeneity between the collected studies was determined using the Cochran’s test (Q) and I2. Meta-regression was used to investigate the factors affecting statistical heterogeneity in 1, 5, and 10-year survival of kidney transplantation in addition to subgroup analysis based on cities. Results: Ten studies were qualified to enter the meta-analysis. The total participants in the study were 2673 people with an average age of 13.71±3.65 years. In the random-effects model, the survival rate of 1, 3, 5 and 10 yr of kidney transplantation were 91, 88, 81 and 70%, respectively. Conclusion: By providing the documented and comprehensive evidence, can be the basis of many plans, policies, and decisions of various sectors of development. These sectors include the evaluation of treatment programs and health interventions in the pediatric kidney transplantation. The results of the present study can provide an acceptable estimate of the survival rate of transplanted children in Iran and will be useful for planning prevention and treatment programs.

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Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 39 publications

The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis

The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis

Attitudes of patients with renal disease on xenotransplantation: A systematic review

Graft and Patient Survival Rate among Iranian Pediatric Recipients of Kidney Transplantation: A Systematic Review and Meta-Analysis

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