The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis

Abstract

Background This study is a systematic review and meta-analysis on published studies about the Global Survival Rate of Graft and Patients in the Kidney Transplantation of children. Methods Studies that investigated the survival rate of kidney transplants published until the 30th of December 2020 were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane. The extracted data were entered into the Excel software and STATA 16.0. The search identified 6007 study references. From the total, we excluded 1348 duplicates, 3688 reference titles and abstracts that were deemed irrelevant, and 846 references that were not original articles (i.e., letter, commentary, review) or did not meet the inclusion criteria. As such, 89 studies involving 12,330 participants were included in this meta-analysis. Results In this study 1, 3, 5, 7 and 10-year survival rates of graft were estimated to be 92, 83, 74.40, 67.10, and 63.50%, respectively. Also, 1, 3, 5, 7 and 10-year survival rates of patients were estimated to be 99.60, 97.30, 95.20, 74.60, and 97.90%, respectively. Conclusions The findings suggest differences in graft and patient survival among children with kidney transplants. Although differences in ethnic origin, incompatibility with deceased donor kidneys, and types of kidney disease are unavoidable, interventions to improve preventive and living-donor transplantation are particularly needed in minority groups. In addition, more research is needed to establish and address the contribution of medical and sociocultural barriers to preferential treatment of these groups.

Predicting Cellular Rejection of Renal Allograft Based on the Serum Proteomic Fingerprint

“…Over the years, serum creatinine testing has been the dominant method for monitoring the well-being of transplanted kidneys due to its widespread availability and familiarity [8]. Nevertheless, the stark reality remains that nearly 20% to 30% of kidney transplant patients experience allograft loss within five years of the surgical procedure, underscoring the urgent requirement for more effective monitoring tools and interventions [9,10].…”

Diagnosis of T-cell-mediated kidney rejection by biopsy-based proteomic biomarkers and machine learning

“…In the United States alone, over 200,000 people are now living with functioning kidney transplants, and rejection is the major cause for transplant loss ( 1 , 2 ). Although short-term graft survival is now excellent ( i.e ., 92% and 83% at 1 and 3 years respectively), the 10-year graft survival rate drops to ~60% due to a spectrum of allograft pathology with a variety of distinct mechanisms and therapeutic options ( 3 ). Timely diagnosis of pathology is imperative in preserving allograft longevity and has traditionally been achieved using conventional biopsy-based histologic methods.…”