The relationship between sarcopenia and central hemodynamics in older adults with falls: a cross-sectional study

Öztorun, Hande Selvi; Bahşi, Remzi; Turgut, Tuğba; Sürmeli, Deniz Mut; Coşarderelioğlu, Çağlar; Atmış, Volkan; Yalçın, Ahmet; Aras, Sevgi; Varlı, Murat

doi:10.1097/mbp.0000000000000569

Cited by 3 publications

(12 citation statements)

References 46 publications

(72 reference statements)

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“…The study by Öztorun et al included 72 older geriatric clinic outpatients (Ankara City Hospital, Ankara, Turkey) who fell at least once during the year preceding enrolment [ 23 ]. For the analyses, we used data from 12 persons without sarcopenia and 28 persons with sarcopenia.…”

Section: Resultsmentioning

confidence: 99%

“…Sun et al used the current AWGS 2019 criteria [ 26 ]. Öztorun et al used the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria with national modification of hand-grip strength cut-offs ( Table 2 ) [ 23 , 28 ]. Ohara et al based their assessment on either the handgrip strength or skeletal muscle mass (SMM).…”

Section: Resultsmentioning

confidence: 99%

“…The study by Öztorun et al used the Mobil-O-Graph cuff-based methodology, which estimates the PWV in the aortic-brachial segment ( Table 2 ) [ 23 ]. The studies by Sun et al, Zhang Y et al, Zhang L et al, Rong et al and Ohara et al used the brachial-ankle cuff-based PWV assessment ( Table 2 ), where the waveforms from the arm and calf are obtained with plethysmographic method [ 22 , 24 , 25 , 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…In three studies (Öztorun et al, Rong et al, Zhang L. et al), the authors presented the odds ratios for sarcopenia given the PWV [ 23 , 24 , 25 ]. All these studies indicated a significantly greater probability of concomitant sarcopenia in persons with greater PWV (all p < 0.04, Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Based on the data from three studies [ 23 , 24 , 25 ], it was possible to obtain odds ratios for sarcopenia concomitantly associated with 1-unit-higher PWV. For the analysis based on mean values of PWV measures, due to the fact that they were obtained with the use of two different modalities, aortic-brachial PWV and the brachial-ankle PWV (baPWV), we calculated standardized mean differences with 95% CI.…”

Section: Methodsmentioning

confidence: 99%

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Pulse Wave Velocity and Sarcopenia in Older Persons—A Systematic Review and Meta-Analysis

Piotrowicz

Klich-Rączka

Skalska

et al. 2022

IJERPH

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Sarcopenia and cardiovascular disease share some of the pathophysiologic mechanisms. Sarcopenia is likewise an important feature of frailty and the one potentially related to cardiovascular pathology. Previously, the relationship between arterial stiffness and frailty has been established. In this study, we conducted a systematic review and a meta-analysis of studies where the relationship between pulse wave velocity (PWV) and sarcopenia has been addressed. We included six cross-sectional studies that enrolled 5476 participants. Using the WebPlotDigitizer, RevMan5, and SAS 9.4, we extracted or calculated the summary statistics. We then calculated standardized mean differences (SMD) of PWV in the sarcopenic and non-sarcopenic participants. The pooled SMD was 0.73 (95% CI 0.39–1.08, p < 0.0001, I2 = 90%) indicating higher value in the sarcopenic subjects. The three studies that presented odds ratios for sarcopenia as a function of PWV homogenously indicated a greater probability of concomitant sarcopenia with higher values of PWV. Greater stiffness of the aorta is associated with sarcopenia. It is impossible to establish the causation. However, the plausible explanation is that increased stiffness may translate into or be an intermediary phenotype of common vascular and muscle damage. On the other hand, sarcopenia, which shares some of the inflammatory mechanisms with cardiovascular disease, may wind up the age-related large arterial remodeling.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Pulse Wave Velocity and Sarcopenia in Older Persons—A Systematic Review and Meta-Analysis

Piotrowicz

Klich-Rączka

Skalska

et al. 2022

IJERPH

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Effects of Exercise Training on Muscle Quality in Older Individuals: A Systematic Scoping Review with Meta-Analyses

et al. 2023

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Background The quantity and quality of skeletal muscle are important determinants of daily function and metabolic health. Various forms of physical exercise can improve muscle function, but this effect can be inconsistent and has not been systematically examined across the health-neurological disease continuum. The purpose of this systematic scoping review with meta-analyses was to determine the effects and potential moderators of exercise training on morphological and neuromuscular muscle quality (MMQ, NMQ) in healthy older individuals. In addition and in the form of a scoping review, we examined the effects of exercise training on NMQ and MMQ in individuals with neurological conditions. Methods A systematic literature search was performed in the electronic databases Medline, Embase, and Web of Science. Randomized controlled trials were included that examined the effects of exercise training on muscle quality (MQ) in older individuals with and without neurological conditions. Risk of bias and study quality were assessed (Cochrane Risk of Bias Tool 2.0). We performed random-effects models using robust variance estimation and tested moderators using the approximate Hotelling–Zhang test. Results Thirty studies (n = 1494, 34% females) in healthy older individuals and no studies in individuals with neurological conditions were eligible for inclusion. Exercise training had small effects on MMQ (g = 0.21, 95% confidence interval [CI]: 0.03–0.40, p = 0.029). Heterogeneity was low (median I2 = 16%). Training and demographic variables did not moderate the effects of exercise on MMQ. There was no association between changes in MMQ and changes in functional outcomes. Exercise training improved NMQ (g = 0.68, 95% CI 0.35–1.01, p < 0.000) across all studies, in particular in higher-functioning older individuals (g = 0.72, 95% CI 0.38–1.06, p < 0.001), in lower extremity muscles (g = 0.74, 95% CI 0.35–1.13, p = 0.001), and after resistance training (g = 0.91; 95% CI 0.42–1.41, p = 0.001). Heterogeneity was very high (median I2 = 79%). Of the training and demographic variables, only resistance training moderated the exercise-effects on NMQ. High- versus low-intensity exercise moderated the exercise-effects on NMQ, but these effects were considered unreliable due to a low number of studies at high intensity. There was no association between changes in NMQ and changes in functional outcomes. Conclusion Exercise training has small effects on MMQ and medium-large effects on NMQ in healthy older individuals. There was no association between improvements in MQ and increases in muscle strength, mobility, and balance. Information on dose-response relations following training is currently lacking. There is a critical gap in muscle quality data for older individuals with lower function and neurological conditions after exercise training. Health practitioners should use resistance training to improve muscle function in older individuals. Well-designed studies are needed to examine the relevance of exercise training-induced changes in MQ in daily function in older individuals, especially to those with lower function and neurological conditions.

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What Might be More Associated with Higher or Lower Blood Pressure in Older Adults? Sarcopenia, Obesity, or Sarcopenic Obesity? A Cross-sectional Retrospective Study

Öztorun¹,

Bahşi²,

Turgut³

et al. 2022

ejgg

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The relationship between sarcopenia and central hemodynamics in older adults with falls: a cross-sectional study

Abstract: Supplemental Digital Content is available in the text.

Cited by 3 publications

References 46 publications

Pulse Wave Velocity and Sarcopenia in Older Persons—A Systematic Review and Meta-Analysis

Pulse Wave Velocity and Sarcopenia in Older Persons—A Systematic Review and Meta-Analysis

Effects of Exercise Training on Muscle Quality in Older Individuals: A Systematic Scoping Review with Meta-Analyses

What Might be More Associated with Higher or Lower Blood Pressure in Older Adults? Sarcopenia, Obesity, or Sarcopenic Obesity? A Cross-sectional Retrospective Study

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