The relationship between retinal and choroidal thickness and visual acuity in highly myopic eyes

Flores‐Moreno, Ignacio; Ruiz‐Medrano, Jorge; Duker, Jay S.; Ruiz-Moreno, José M.

doi:10.1136/bjophthalmol-2012-302836

Cited by 85 publications

(60 citation statements)

References 26 publications

(30 reference statements)

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“…In our study BCVA was directly related to the thickness of the choroid with lower BCVA associated with lower macular choroid thickness. This finding is in agreement with previous reports where CT was found to be the most important predictor for visual acuity in highly myopic eyes without macular pathology [17,31,32]. …”

Section: Discussionsupporting

confidence: 83%

Influence of Macular Choroidal Thickness on Visual Function in Highly Myopic Eyes

et al. 2014

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Purpose: To explore the retinal and choroidal thicknesses (RT, CT), as measured using enhanced depth imaging (EDI) optical coherence tomography (OCT, Spectralis) in highly myopic eyes and its relationship with visual function. Materials and Methods: Prospective, case-control, noninterventional clinical study. CT was measured by EDI-OCT in highly myopic eyes (≥6 dpt) without any macular diseases and age-matched control eyes. A complete ophthalmological examination, visual acuity assessment and MP1 microperimetry were obtained. Results: 38 myopic (15 M/23 F, mean age 51 ± 8.9 years) and 21 control eyes (5 M/16 F, mean age 50 ± 5.4 years) were included. The myopic mean refractive error was -13.3 ± 4.9 dpt and axial length 29.2 ± 2.2 mm. The mean best-corrected visual acuity (BCVA) was lower in highly myopic than in control eyes (77.3 ± 9.25 vs. 84.8 ± 0.6 letters, p = 0.0001, respectively) as was the mean retinal sensitivity (MRS; 16.32 ± 2.6 vs. 19.9 ± 0.2 dB, p < 0.0001). While RT was similar between groups (291.5 ± 24.2 vs. 283.6 ± 13.9 µm, p = 0.06, respectively), subfoveal CT was thinner in highly myopic compared to control eyes (114.3 ± 78.5 vs. 272.6 ± 110.2 µm, p < 0.0001). A significant relationship was found between subfoveal CT and MRS (R² = 0.22; p = 0.003) and BCVA (R² = 0.13; p = 0.027). Conclusions: Macular function is reduced in highly myopic eyes without any visible macular diseases compared to controls, and a significant proportion of the macular function variability seems to be related to a reduced CT.

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Section: Discussionsupporting

confidence: 83%

Influence of Macular Choroidal Thickness on Visual Function in Highly Myopic Eyes

et al. 2014

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“…34,35 Additionally, beta-PPA was related to axial length in ours and previous studies. 14,16,17 Eyes with longer axial length might have thinner 36 or more atrophic RPE, more susceptible to degeneration. Also in accordance with previous studies, 13,17 beta-PPA was related to older age in our multivariate analysis, whereas gamma-PPA was not.…”

Section: Discussionmentioning

confidence: 99%

Beta and Gamma Peripapillary Atrophy in Myopic Eyes With and Without Glaucoma

Vianna

Malik

Danthurebandara

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine whether beta and gamma peripapillary atrophy (PPA) areas measured with optical coherence tomography (OCT) enhances glaucoma diagnosis in myopic subjects.METHODS. We included 55 myopic glaucoma patients and 74 myopic nonglaucomatous controls. Beta-PPA comprised the area external to the clinical disc margin, with absence of retinal pigment epithelium and presence of Bruch's membrane. Gamma-PPA comprised the area external to the disc margin, with absence of both RPE and Bruch's membrane. OCT scans colocalized to fundus photographs were used to measure PPA, choroidal thickness, border tissue of Elschnig configuration, optic disc area, and optic disc ovality. 2 , respectively). However, the distributions of both beta-and gamma-PPA in the two groups overlapped widely. The areas under the receiver operating characteristic curve of beta-and gamma-PPA areas were 0.60 and 0.59, respectively. Larger beta-PPA area was associated with larger disc area, thinner choroidal thickness, longer axial length, less oblique border tissue configuration, older age, and greater disc ovality. Larger gamma-PPA area was associated with greater disc ovality, more oblique border tissue configuration, and longer axial length. RESULTS.CONCLUSIONS. Subclassifying PPA with OCT into beta and gamma zones reveals association with different covariates, but does not enhance the diagnostic performance for glaucoma in a population of predominantly Caucasians myopic subjects.

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“…First, the mean age of the myopic group was 23.1 ± 2.4 years (20-27), significantly younger age compared with that in other studies (26,27) . Second, the mean spherical equivalent refraction was -7.1 ± 1.75 D in the myopic group, a smaller value than the -12.05 ± 5.02 D value reported by Flores-Moreno et al (27) and -11.9 D (± 3.7 D) value reported by Fujiwara et al (26) . CT is known to decrease with increasing age and degree of myopia.…”

Section: Discussionmentioning

confidence: 79%

“…Thinner CT is associated with poorer visual acuity in highly ME as shown by Flores-Moreno et al (27) . They demonstrated that subfoveal CT, mean macular CT, and outer foveal thickness are the most important predictors of visual acuity in highly ME without macular pathology.…”

Section: Discussionmentioning

confidence: 85%

“…Fujiwara et al (26) reported a subfoveal CT of 93.2 μm (±62.5 μm) using the Spectralis with EDI, the same instrument using the present study. Further, Flores-Moreno et al (27) reported a mean subfoveal CT of 166 ± 88.7 μm (13.5-486.5) using the Topcon 3 D-2000 OCT in a pattern that facilitates the visualization of deeper ocular structures, similar to the EDI in Spectralis. There may be at least two possible reasons for this difference.…”

Section: Discussionmentioning

confidence: 99%

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Choroidal thickness variation in highly myopic eyes during the water drinking test

Germano¹,

Hatanaka²,

Susanna³

2016

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate variations in choroidal thickness (CT) during the water drinking test (WDT) in emmetropic eyes (EE) and highly myopic eyes (ME) using spectral-domain optical coherence tomography (SD-OCT). Methods: Clinical trial performed at a tertiary care hospital comprising 30 randomly selected eyes. The WDT and SD-OCT macular scans were performed 10 and 45 min after water ingestion in 15 myopic and 15 EE of 15 healthy patients in each group. Primary study outcomes were average macular CT measured by SD-OCT and intraocular pressure (IOP) during the WDT. Results: The mean spherical equivalent refraction was 0.15 ± 0.24 D in emmetropic and -7.1 ± 1.75 D in ME (p<0.001). No statistical differences between EE and ME were observed during the WDT response. EE had higher CT compared with ME at the fovea (361.4 ± 55.4 vs 257.9 ± 95.3; p<0.001), 3 mm nasal to the fovea (158.0 ± 71.8 vs 122.5 ± 54.5; p=0.047), and 3 mm temporally to the fovea (310.6 ± 52.4 vs 247.6 ± 90.1; p=0.05). Regarding CT variation, significant differences in foveal CT at 10 min after water ingestion were observed in both EE and ME, with no statistically significant difference observed between groups. A moderate correlation between IOP peak during the WDT and CT was demonstrated in ME (r=0.52; p=0.04). Conclusions:No statistically significant differences in CT variation during the WDT were observed between EE and ME, indicating similar behavior of the choroidal bed during the WDT in both groups. Further, CT was thinner in highly ME, with CT variation unable to explain elevations in IOP observed during the WDT.

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The relationship between retinal and choroidal thickness and visual acuity in highly myopic eyes

Abstract: Subfoveal choroidal thickness, mean macular choroidal thickness and outer retinal thickness are the most important predictive factors of visual acuity in highly myopic eyes without macular pathology. Outer nuclear layer and foveal thickness are not related to visual acuity.

Cited by 85 publications

References 26 publications

Influence of Macular Choroidal Thickness on Visual Function in Highly Myopic Eyes

Influence of Macular Choroidal Thickness on Visual Function in Highly Myopic Eyes

Beta and Gamma Peripapillary Atrophy in Myopic Eyes With and Without Glaucoma

Choroidal thickness variation in highly myopic eyes during the water drinking test

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