This research examines the level of pre-exposure prophylaxis (PrEP) self-efficacy
among HIV-negative men who have sex with men (MSM) in China and identifies the
influencing factors associated with the level of PrEP self-efficacy in terms of
social-demographic characteristics and social psychological factors. The data
were gathered from a baseline assessment of a longitudinal randomized controlled
intervention trial. From April 2013 to March 2015, nonprobability sampling was
used to recruit HIV-negative MSM at Chongqing, Guangxi, Xinjiang, and Sichuan in
west China. A total of 1884 HIV-negative MSM were analyzed. Chi-square test and
nonparametric rank sum test were used for univariate analysis. Multivariable
linear regression analysis was used to discuss the factors that influence the
level of PrEP self-efficacy. Overall levels of PrEP self-efficacy were low, and
five factors were found to effect PrEP self-efficacy: age, residence,
AIDS-related knowledge, PrEP-related motivation, and anxiety. Age and anxiety
score were negatively related to PrEP self-efficacy. The higher the age and
anxiety score, the lower the PrEP self-efficacy. AIDS-related knowledge and
PrEP-related motivation were actively related to PrEP self-efficacy. The higher
the knowledge and motivation score, the higher the PrEP self-efficacy. In
addition, the PrEP self-efficacy level of MSM in rural areas is lower than that
in urban areas. The lower level of self-efficacy in the MSM population needs to
be improved. Pertinent interventions should be taken to promote the
self-efficacy of PrEP in MSM, to enhance their willingness to take medicine,
improve their medication adherence, and thus reduce HIV infection among MSM.