The purpose of this review is to research the awareness of and willingness to use pre-exposure prophylaxis (PrEP) to protect themselves from HIV infection amongst MSM in China. In addition, we explored the potential impact factors and evaluated the need and user preferences related to access and utilization ofPrEP in China. PUBMED, EMBASE, and CNKI were accessed to search for the relevant articles published before August 2019. The studies included in this review were conducted in 9 cities in China. The awareness of PrEPuse was from 11.2% (Zhou et al., 2012) to 52.7% (Peng et al., 2019). The lowest willingness to use PrEP was 19.1% (Ding et al., 2016), the highest is 91.9% (Wei et al., 2011) provided the drug is safe, effective and free. Assuming HIV prevention medicines are effective and safe, the willingness to use PrEP was in the range of 63%-89.8%. Factors associated with willingness to use PrEPinclude the factors of drug products (e.g., perceived safety, efficacy, price and dosing schedule, etc.); sociodemographic characteristics (e.g., age, education, income, sex identity and sex role, etc.); behavioral factors (e.g., drug use, condom use, STI history and sex partner, etc.), and the awareness and knowledge of HIV treatment and prevention. Results indicate that as more MSM in China are becoming aware of PrEP, the willingness to use PrEP is higher than 63% if the medicine is safe and effective. Future research is needed to solicit effective education and intervention programs to support the access and use of PrEP.