The Relationship between Pulmonary Function and Serum Uric Acid Level in the Korean Population

Abstract

Background: Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and the ratio of FEV1 to FVC (FEV1/FVC) are considered as the major spirometry parameters. Serum uric acid is associated with increased risk of gout and cardiovascular disease. We analyzed the relationship between pulmonary function and serum uric acid level in the Korean men and women. Methods: This study was based on the data collected during the 2016 Korea National Health and Nutrition Examination Survey (KNHANES VII-1). A total of 3,411 adults were retrieved from KNHANES VII-1. Among 3,411 adults, 1,500 were men and 1,911 were women. Results: In this study, a significant negative correlation was observed between serum uric acid level and pulmonary function values only in females. Also, in the male non-smoker group, pulmonary function values were negatively associated with serum uric acid level (FVC %predicted, β=-0.014; FEV1 %predicted, β=-0.015). Conclusions: In this study, hyperuricemia was associated with the low lung function in males and females. In order to obtain an accurate assessment of the association between hyperuricemia and pulmonary function values, further prospective cohort study in the future is necessary.

Lung function decline is associated with serum uric acid in Korean health screening individuals

“…Although the differences did not attain statistical significance, the data indicate that uric acid may play a pro-inflammatory role in terms of LF. In another cross-sectional study, significant negative correlations were observed between the serum uric acid level and LF in both male and female 54 . The pro-inflammatory effects of uric acid may compromise the LF of non-smokers, as discussed above.…”