Lung function decline is associated with serum uric acid in Korean health screening individuals

Ahn, Kyung Min; Lee, Suh Young; Lee, So Hee; Kim, Sun Sin; Park, Heung-Woo

doi:10.1038/s41598-021-89678-3

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…Open access linear mixed models. 43 Nevertheless, our study was inconsistent with another Korean study, which demonstrated there was a significant positive relationship between SUA and lung function parameters, among 69 928 participants recruited from Kangbuk Samsung Hospital Health Screening Center, Seoul, Korea. 44 The Korean study excluded the participants with a self-reported history of underlying diseases, including hypertension history, diabetes history, respiratory diseases history and so on.…”

Section: Discussioncontrasting

confidence: 97%

Association between serum uric acid/serum creatinine ratios and lung function in the general American population: National Health and Nutrition Examination Survey (NHANES), 2007–2012

Wen

Wei²,

Giri³

et al. 2023

BMJ Open Resp Res

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BackgroundAssessment of lung function is essential for the early screening chronic airway diseases (CADs). Nevertheless, it is still not widely used for early diagnosing CADs in epidemiological or primary care settings. Thus, we used data from the US National Health and Nutrition Examination Survey (NHANES) to discuss the relationship between the serum uric acid/serum creatinine (SUA/SCr) ratio and lung function in general adults to gain the role of SUA/SCr in early assessment of lung function abnormalities.MethodsFrom 2007 to 2012 NHANES, a total of 9569 people were included in our study. Using the regression model, XGBoost algorithm model, generalised linear model and two-piecewise linear regression model, the link between the SUA/SCr ratio and lung function was investigated.ResultsAfter correcting for confounding variables, the data revealed that forced vital capacity (FVC) declined by 47.630 and forced expiratory volume in one second (FEV1) decreased by 36.956 for each additional unit of SUA/SCr ratio. However, there was no association between SUA/SCr and FEV1/FVC. In the XGBoost model of FVC, the top five most important were glycohaemoglobin, total bilirubin, SUA/SCr, total cholesterol and aspartate aminotransferase, whereas in FEV1, were glycohaemoglobin, total bilirubin, total cholesterol, SUA/SCr and serum calcium. In addition, we determined the linear and inverse association between SUA/SCr ratio and FVC or FEV1 by constructing a smooth curve.ConclusionsIn the general American population, the SUA/SCr ratio is inversely linked with FVC and FEV1, but not with FEV1/FVC, according to our research. Future studies should investigate the impact of SUA/SCr on lung function and identify possible mechanisms of action.

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Section: Discussioncontrasting

confidence: 97%

Association between serum uric acid/serum creatinine ratios and lung function in the general American population: National Health and Nutrition Examination Survey (NHANES), 2007–2012

Wen

Wei²,

Giri³

et al. 2023

BMJ Open Resp Res

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show abstract

“…Another study conducted in Japan, 13 involving 2917 participants, reported that the predicted values of FEV1% and FVC% in females were inversely associated with UA. A final study from Korea 22 was conducted, a retrospective cohort analysis comprising 19 237 individuals who underwent at least three health screenings and were followed up for over 5 years. The study utilized linear mixed models to observe an accelerated decline in FVC and the FEV1/FVC ratio among non‐smokers with elevated serum UA levels.…”

Section: Discussionmentioning

confidence: 99%

Association between serum uric acid levels and lung function in the NHANES cohort (2007–2012): A cross‐sectional analysis of a diverse American population

Kang,

Xi,

et al. 2024

Int J of Rheum Dis

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BackgroundHyperuricemia has been linked to various health conditions. However, the relationship between uric acid (UA) levels and lung function remains debated.MethodsIn a cross‐sectional study of 6750 participants aged 20–69 from NHANES, we assessed UA levels and lung function (FVC and FEV1). We conducted regression analyses while adjusting for potential confounders.ResultsAfter accounting for factors like age, sex, BMI, smoking, and more, we found a negative association between UA FVC and FEV1. Specifically, for every 0.1 mg/dL increase in UA, FEV1 decreased by 15.265 mL, and FVC decreased by 24.46 mL. No association was observed with FEV1/FVC. Subgroup analyses revealed similar negative correlations among various groups, particularly in non‐Hispanic Black females under 60.ConclusionSerum UA levels are inversely associated with FEV1 and FVC in the American population, with a notable impact on non‐Hispanic Black females under 60.

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“…A study using an experimental model of ILD demonstrated that bleomycin-induced lung injury triggers local production of UA, thereby activating the NALP3 inflammasome in the lung and perpetuating lung damage [ 28 ]. In addition, higher SUA and BALF-UA levels have been associated with worse pulmonary function at spirometry not only in RA-ILD but also in healthy subjects [ 27 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Interplay between Cardiovascular Risk, Cardiovascular Events, and Disease Activity in Primary Sjögren’s Syndrome: Is Uric Acid the Missing Link?

et al. 2023

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(1) Background: Uric acid is a well-known cardiovascular (CV) risk factor in the general population but its role in the setting of rheumatic diseases other than gout is unclear. (2) Methods: This is a retrospective study investigating a cohort of 105 pSS patients recording clinical, serological, and CV-related variables including adherence to the Mediterranean diet. (3) Results: We observed a strong relationship between disease activity, interstitial lung disease (ILD), and CV events. The association between ILD and CV events was dependent on higher SUA levels but independent of other traditional CV risk factors. All three cases of previous non-fatal stroke were reported by females aged <65 years, with higher SUA levels, and two of them also had pSS-ILD. Forty (38%) patients had a 10-year risk of fatal and non-fatal CV disease events beyond the cut-off recommended for their age, and using the correction factor of 1.5 currently applied only to rheumatoid arthritis, we could better identify patient subsets characterized by different CV risk profiles including different SUA levels. (4) Conclusions: This study is the first to investigate in depth the role of SUA in the CV scenario of pSS. Our findings underpin the importance of assessing SUA levels in pSS in addition to the other traditional CV risk factors and to consider applying the correction factor for CV risk assessment tools to achieve a better stratification of CV risk.

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Lung function decline is associated with serum uric acid in Korean health screening individuals

Cited by 6 publications

References 62 publications

Association between serum uric acid/serum creatinine ratios and lung function in the general American population: National Health and Nutrition Examination Survey (NHANES), 2007–2012

Association between serum uric acid/serum creatinine ratios and lung function in the general American population: National Health and Nutrition Examination Survey (NHANES), 2007–2012

Association between serum uric acid levels and lung function in the NHANES cohort (2007–2012): A cross‐sectional analysis of a diverse American population

The Interplay between Cardiovascular Risk, Cardiovascular Events, and Disease Activity in Primary Sjögren’s Syndrome: Is Uric Acid the Missing Link?

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