The relationship between platelet-to-lymphocyte ratio and pulmonary embolism severity in acute pulmonary embolism

Telo, Selda; Kuluöztürk, Mutlu; Deveci, Figen; Kırkıl, Gamze

doi:10.23736/s0392-9590.18.04028-2

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…Telo et al [18] further showed that PLR and NLR were increased in high-risk PE patients. They indicated that PLR may have a prognostic value to predict 3-month mortality, whereas NLR may have prognostic value for in-hospital, 3 th month, and total 3-month mortality [18]. According to Ertem et al [19], LMR may also be used to predict short-term mortality in acute PE cases.…”

Section: Discussionmentioning

confidence: 95%

“…In another, recent study, NLR as well as mean platelet volume (MPV) were suggested to be useful in the early detection of acute venous thromboembolism [17]. Telo et al [18] further showed that PLR and NLR were increased in high-risk PE patients. They indicated that PLR may have a prognostic value to predict 3-month mortality, whereas NLR may have prognostic value for in-hospital, 3 th month, and total 3-month mortality [18].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism

Köse

Yıldırım

Akın

et al. 2019

Bosn J of Basic Med Sci

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Pulmonary embolism (PE) is associated with significant morbidity and mortality. New biological markers are being investigated for estimating the prognosis of PE patients. Since PE is closely associated with inflammatory status, the neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR), and lymphocyte-monocyte (LMR) ratios were suggested to be useful in predicting patient outcomes. This study aimed to evaluate the prognostic role of NLR, PLR, and LMR in PE. A total of 103 PE cases from a cardiology department were included in the study. Control group consisted of 102 patients selected from outpatient clinics other than cardiology, cardiovascular surgery, and chest diseases. We retrospectively evaluated demographic and clinical characteristics, treatments, laboratory and imaging findings, and outcomes of patients. The median follow-up of PE patients was 39 months, and the 5-year overall survival probability was 73.8%. Out of 103 patients, 20 were classified as high risk PE cases (19.4%). Thrombolytic treatment was administered to 23 patients (22.3%). Systolic pulmonary arterial pressure was measured during one year, showing a significant decrease from 51.7 ± 15.7 mmHg at admission to 26.6 ± 4.0 mmHg at first year assessment. Age (OR: 1.06, p < 0.001) and NLR (OR: 1.52, p < 0.0019) were significantly associated with the disease status. The independent prognostic factors in moderate-low and low risk PE groups were NLR (HR: 1.17, p = 0.033) and LMR (HR: 1.58, p = 0.046). In moderate-high and high risk PE patients, the independent prognostic factors were age (HR: 1.07, p = 0.014) and PLR (HR: 1.01, p = 0.046). NLR, PLR, and LMR were associated with the prognosis of PE patients. The clinical severity of PE should be considered when utilizing these markers to assess patient outcomes.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism

Köse

Yıldırım

Akın

et al. 2019

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

show abstract

“…Telo et al revealed that NLR was significantly higher in PE patients with high-risk for mortality than in those with low-risk for mortality based on the sPESI score (p<0.01). 19 NLR had a predictive sensitivity of 66%, a specificity of 53% and an AUC of 0.675 (95% CI: 0.556–0.794). All patients were divided into two groups according to the NLR cut-off value of 3.56, showing statistically significant increase in-hospital mortality, 3rd month mortality and overall 3-month mortality in the groups above 3.56 ( χ 2 =4.771, p<0.05; χ 2 =4.383, p<0.05; χ 2 =9.101, p<0.01).…”

Section: Nlr and Vtementioning

confidence: 99%

Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?

Xue¹,

Ma²,

Jia³

et al. 2021

JIR

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Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), has been an important cause of sudden in-hospital death. Studies have shown that the immune/inflammatory response plays an important role in the pathogenesis of vascular disease, with representative markers in the blood including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), systemic immune/inflammatory index (SII), etc. However, there is a variety of immune/inflammatory indicators. Moreover, most previous studies have been single-center investigations involving one or two indicators, with varying nature of cases, number of cases and study objectives, thereby making it difficult to reach consensus conclusions with good clinical guidelines. This article reviews the clinical value of immunoinflammatory indicators for VTE based on previous studies, including the diagnostic and prognostic capabilities. In conclusion, NLR provides promising predictive capability for the onset and prognosis of VTE and deserves extensive application in clinical practice. PLR also has certain diagnostic and prognostic value, but further studies are warranted to identify its reliability and stability. Monocytes, eosinophils and platelet-related indicators show some clinical association with VTE, although the predictive capabilities are mediocre. SII is of promising potential value for VTE and deserves further investigations. This review will provide new clues and valuable clinical guidance for the diagnosis and therapy of VTE.

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“…Whether platelet count can be used as a marker of activation is currently controversial. Ozcan Cetin E, et al [28] reported that increased platelet was closely correlated with the RVD and disease severity in APE patients that are consistent with Telo S' research [29]. Contrarily, decreased platelet count has been shown to re ect an aggravated thrombocyte activity and that lead to destructive thrombotic response [30].…”

Section: Discussionmentioning

confidence: 63%

D-dimer-to-platelet Ratio as a Novel Marker of in-hospital Adverse Outcomes Among Patients With Acute Pulmonary Embolism: a Single-center Retrospective Study

Shang³

et al. 2021

Preprint

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Background: This retrospective study aimed to evaluate the value of D-dimer to platelets ratio (DPR) in predicting the in-hospital prognosis of patients with acute pulmonary embolism (APE).Methods: We retrospectively reviewed the medical records of 237 patients with APE admitted from January 2016 to August 2020. The associations between the DPR and other predictors and serious adverse events were analyzed with univariate and multivariate analyses.Results: A total of 134 (56.5%) patients were categorized into the low DPR group (DPR <4.55) and 103 (43.5%) in the high DPR group (DPR ≥4.55) according to the cut-off value for the DPR of 4.55 with a sensitivity of 87.5% and a specificity of 62.0%, respectively. The model that included DPR revealed a significant improvement in the accuracy of the predictive value compared with the sPESI score alone (AUC: 0.721 [95% CI: 0.636-0.807]; P <0.001 vs AUC: 0.607 [95% CI: 0.496-0.718]; P=0.085; respectively. Multivariate analysis showed that DPR (P=0.001) and the pulmonary embolus position (P=0.011) were independent factors of serious adverse events (SAEs) of APE inpatients. The in-hospital SAEs rate was significantly higher in the high DPR group compared with the low DPR group.Conclusion: Our findings showed that DPR is seemed to be a novel marker of risk stratification in patients with APE. This parameter may be used to identify these patients at higher risk for clinical adverse events, and individualization of therapeutic interventions should be timely considered.

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The relationship between platelet-to-lymphocyte ratio and pulmonary embolism severity in acute pulmonary embolism

Cited by 19 publications

References 25 publications

Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism

Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism

Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?

D-dimer-to-platelet Ratio as a Novel Marker of in-hospital Adverse Outcomes Among Patients With Acute Pulmonary Embolism: a Single-center Retrospective Study

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