The relationship between plasma ferritin levels and body mass index among adolescents

Shattnawi, Khulood Kayed; Alomari, Mahmoud A.; Al-Sheyab, Nihaya; Salameh, Ayman Bani

doi:10.1038/s41598-018-33534-4

Cited by 31 publications

(26 citation statements)

References 20 publications

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“…A double-blinded placebo controlled cohort study on 9917 subjects carried out in Paris in 1995, concluded consistent results with this study finding in that BMI is significantly associated with SFL. (21) A study in Spain in 1998, revealed that BMI is correlated with ferritin, (22) which is consistent with the present study findings of a significant association between SFL and BMI (P value= 0.001), odd ratio shows that being obese is a risk factor for having low SFL (table 2). Which is may be related to wrong eating habit, diet and lifestyle among those obese individuals.…”

Section: Discussionsupporting

confidence: 91%

Serum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological outpatient clinics in BaghdadSerum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological

Al-Nakash¹,

Raheem²

2020

Al-Kindy Col. Med. J

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Background: Hair loss is a common distressing disease and challenging problem for many dermatologist. Telogen effluvium is the most common hair loss disease in which nutritional deficiencies may precipitate the disease through their effect on hair structure and growth. Study Aim : Validating role of serum ferritin level and body mass index in Chronic Telogen Effluvium and analyzing association between these factors with socioeconomic, demographic, gynecological factors and weight loss effect. Establishing a nutritional preventive advice to improve treatment successfulness and decrease the disease occurrence. Methods : A case series study on 327 chronic telogen effluvium patients (15-65 years old) main teaching dermatological outpatients' clinics in Baghdad. Data were collected by direct interview and questionnaire filling to analyze the associations between variables set in the data collection tool with serum ferritin level and body mass, which in turn may precipitate chronic telogen effluvium. Results :Mean patients' age was 39±9 years, 93.6% of patients had serum ferritin below normal for hair cycle requirement (≤70μg/l). Serum ferritin significantly associated with age (p value= 0.002) and 41.1% of poor socioeconomic patients had serum ferritin ≤20μg/l. Nearly half of the patients with ≥3 pregnancies, 43.9% of patients on weight-losing diet and 52.7% of those who actually lost weight had low ferritin levels with statistically significant associations. Being obese is a risk factor for having low serum ferritin (OR= 0.297). Conclusion : Serum ferritin found to be ≤ 70μg/l in the majority of chronic telogen effluvium patients, which is significantly associated with patients' socioeconomic status, age, and weight status.

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Section: Discussionsupporting

confidence: 91%

Serum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological outpatient clinics in BaghdadSerum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological

Al-Nakash¹,

Raheem²

2020

Al-Kindy Col. Med. J

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“…Interestingly, the direction of correlation between ferritin levels and BMI or BF% in female athletes was the opposite of that in males. Males with higher BMI showed higher ferritin levels, consistent with previous studies [ 31 , 32 ], and obesity-related inflammatory processes may be an explanation for such a relationship [ 33 ]. Conversely, an inverse correlation between ferritin levels and BMI has been reported in female adolescents [ 34 ].…”

Section: Discussionsupporting

confidence: 90%

Prevalence of iron deficiency among university kendo practitioners in Japan: an observational cohort study

Nabeyama

Suzuki

Yamamoto

et al. 2020

Journal of the International Society of Sports Nutrition

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Background Iron deficiency is widely recognized as being the cause of anemia in athletes, although iron status in athletes of Kendo, a traditional Japanese martial art based on swordsmanship and practiced as an educational sport, has not been widely investigated. Methods We performed a health assessment on anemia and serum ferritin levels, along with nutrient intake evaluation, for Kendo practitioners in a university in Japan. Results A total of 56 Kendo practitioners (39 male and 17 female) aged between 18 and 23 years participated in the study. No individuals exhibited WHO-defined anemia (less than 13 or 12 g/dL of hemoglobin levels in male or female), while hypoferritinemia (less than 30 ng/mL) was found in seven (41%) females but not in males. Significantly higher body mass index was found in the female athletes with hypoferritinemia compared to females with normo-ferritinemia in sub-analysis (median [interquartile range]; 25.6 [24.2, 26.9] versus 22.6 [21.7, 24.1], respectively. p < 0.05). No significant differences in the intake of iron were registered between males and females (with and without hypoferritinemia) using data from a food-frequency questionnaire survey. Conclusion No apparent anemia was found in adolescent Kendo practitioners, although this study confirmed the presence of hypoferritinemia in several female athletes. Careful follow-up, involving both clinical and nutritional assessment, will be necessary for them to prevent progression into anemia. A future study with larger cohorts in multiple sites is warranted to assess the prevalence of iron deficiency for validation and, if necessary, to devise a strategy for improving the iron status in Kendo athletes.

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“…Thus, to clarify whether the higher hepcidin values we found were due to impaired iron metabolism (namely, iron overload) or, on the other hand, were already causing iron deficiency, we evaluated three key markers of iron status: ferritin, transferrin and soluble transferrin receptor, which can also provide an assessment of the distal consequences of the elevated hepcidin levels we found. In fact, ferritin levels in adolescents have been suggested by others as an important early indicator for the risk of developing metabolic disorders [ 20 , 21 ]. Another aspect that deserves further attention in the light of these findings is the interaction between copper and iron metabolism.…”

Section: Discussionmentioning

confidence: 99%

Higher Hepcidin Levels in Adolescents with Obesity Are Associated with Metabolic Syndrome Dyslipidemia and Visceral Fat

et al. 2021

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Tightly regulated iron metabolism prevents oxidative stress. Hepcidin is a hormone that regulates iron flow in plasma; its production is induced by an iron overload and by inflammation. It inhibits iron entry into the circulation by blocking dietary absorption in the duodenum, the release of recycled iron from macrophages and the exit of stored iron from hepatocytes. Varied signals responding to iron stores, erythropoietic activity and host defense converge to regulate hepcidin production and thereby affect iron homeostasis. Although it is known that hepcidin increases when interleukin 6 (IL-6) increases, the relationship between hepcidin, dyslipidemia, insulin resistance (IR) and visceral adiposity index (VAI) in adolescents with obesity is unclear. In this cross-sectional study of 29 obese adolescents and 30 control subjects, we explored the difference of hepcidin, iron metabolism markers and IL-6 between obese and non-obese adolescents, and identified associations with inflammation, atherogenic dyslipidemia and IR. As compared to lean controls, obese participants showed 67% higher hepcidin: 14,070.8 ± 7213.5 vs. 8419.1 ± 4826.1 pg/mLc; 70% higher ferritin: 94.4 ± 82.4 vs. 55.1 ± 39.6 pg/mLa and 120% higher IL-6: 2.0 (1.1–4.9) vs. 0.9 (0.5–1.3) pg/mLd. Transferrin, soluble transferrin receptor and total body iron (as measured by sTFR/ferritin, log10 sTFR/ferritin ratio and sTFR/log ferritin ratios) were not different between the two cohorts. In the whole cohort, hepcidin correlated with VAI (r = 0.29a), sd-LDL (r = 0.31b), HOMA-IR (r = 0.29a) and IL-6 (r = 0.35c). In obese adolescents hepcidin correlated with TG (r = 0.47b), VLDL-C (r = 0.43b) and smaller LDL2 (r = 0.39a). Hepcidin elevation in adolescents with obesity is linked more to inflammation and metabolic alterations than to iron metabolism since the other markers of iron metabolism were not different between groups, except for ferritin. Studies addressing the long-term effects of higher hepcidin levels and their impact on subclinical anemia and iron status are warranted. a p < 0.05; b p < 0.01, c p < 0.001 dp < 0.0001.

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The relationship between plasma ferritin levels and body mass index among adolescents

Cited by 31 publications

References 20 publications

Serum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological outpatient clinics in BaghdadSerum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological

Serum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological outpatient clinics in BaghdadSerum Ferritin and Body Mass Index in Chronic Telogen Effluvium among women attending the main dermatological

Prevalence of iron deficiency among university kendo practitioners in Japan: an observational cohort study

Higher Hepcidin Levels in Adolescents with Obesity Are Associated with Metabolic Syndrome Dyslipidemia and Visceral Fat

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